{"title":"ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility","authors":"Bernhard Magerl, Tommaso Cavazza","doi":"10.1038/s41594-024-01475-4","DOIUrl":null,"url":null,"abstract":"Aneuploidy is a major cause of embryonic failure and miscarriage. A new study identifies genetic variants of ELL3 associated with miscarriage and discovers a novel role for ELL3 in female meiosis.","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"32 2","pages":"217-219"},"PeriodicalIF":12.5000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Structural & Molecular Biology","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41594-024-01475-4","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Aneuploidy is a major cause of embryonic failure and miscarriage. A new study identifies genetic variants of ELL3 associated with miscarriage and discovers a novel role for ELL3 in female meiosis.
期刊介绍:
Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.