Development of an optimal simulated-moving-bed process for continuous separation of β-mangostin from mangostin mixture generated through mangosteen processing

IF 8.1 1区 工程技术 Q1 ENGINEERING, CHEMICAL Separation and Purification Technology Pub Date : 2025-01-21 DOI:10.1016/j.seppur.2025.131728
Cheol Yeon Jo, Seong Je Seo, Hoe-Jong Kang, Sungyong Mun
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Abstract

There has recently been an industrial interest in β-mangostin, because of the potential for its industrial utilization. An essential requirement for the industrial-scale production of β-mangostin is the highly efficient and economical separation of β-mangostin from mangostin mixture that comes from mangosteen processing. To address this issue, we aimed to develop an optimal simulated-moving-bed (SMB) process for continuous separation of β-mangostin from the aforementioned mangostin mixture with high economical-efficiency, i.e. high productivity. As a first step for this work, the information on the adsorption and mass-transfer behaviors and related parameters for each mangostin component was obtained through single-column experiments, multiple-frontal analysis method, literature correlations, and model fitting, and the SMB optimization computer program based on standing-wave-design frame was constructed. These two were then used to maximize the productivity of the β-mangostin separation SMB (abbreviated as “β-SMB”). According to the results from such optimization, the highest productivity is attained when the particle size of the β-SMB adsorbent is chosen in such a way that the effects of the pressure-drop requirement (SMB pressure drop ≤ 100 psi) and separation-capability requirement (yields of product and non-products ≥ 99.9 %) factors on the β-SMB productivity can balance each other. It was also found that an effective way to further improve the β-SMB productivity is to mitigate the influence of the latter factor by slightly downgrading the target level of β-mangostin yield or strengthening the functions of separation zones. Furthermore, it was confirmed that the simultaneous use of the two aforementioned methods could create a synergy effect, thereby increasing the β-SMB productivity by about 158 % compared to the reference β-SMB process where only the operating conditions were optimized.
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开发了一种优化的模拟移动床工艺,用于从山竹加工产生的山竹苷混合物中连续分离β-山竹苷
由于β-山竹苷具有工业利用的潜力,最近引起了工业界的兴趣。β-山竹苷工业化生产的基本要求是从山竹加工所得的山竹苷混合物中高效、经济地分离β-山竹苷。为了解决这一问题,我们旨在开发一种优化的模拟移动床(SMB)工艺,用于从上述山竹苷混合物中连续分离β-山竹苷,具有较高的经济效率,即高生产率。作为本工作的第一步,通过单柱实验、多面分析、文献关联、模型拟合等方法获得了各组分的吸附传质行为及相关参数,构建了基于驻波设计框架的SMB优化计算机程序。然后利用这两种方法最大限度地提高β-山竹苷分离SMB(简称“β-SMB”)的生产率。优化结果表明,当β-SMB吸附剂的粒径选择使压降要求(SMB压降 ≤ 100 psi)和分离能力要求(产物和非产物产率 ≥ 99.9 %)对β-SMB产率的影响相互平衡时,β-SMB的产率达到最高。进一步提高β-SMB产量的有效途径是通过略微降低β-山竹苷产量目标水平或加强分离带的功能来减轻后者的影响。此外,证实了上述两种方法同时使用可以产生协同效应,从而使β-SMB的生产率比仅优化操作条件的参考β-SMB工艺提高约158 %。
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来源期刊
Separation and Purification Technology
Separation and Purification Technology 工程技术-工程:化工
CiteScore
14.00
自引率
12.80%
发文量
2347
审稿时长
43 days
期刊介绍: Separation and Purification Technology is a premier journal committed to sharing innovative methods for separation and purification in chemical and environmental engineering, encompassing both homogeneous solutions and heterogeneous mixtures. Our scope includes the separation and/or purification of liquids, vapors, and gases, as well as carbon capture and separation techniques. However, it's important to note that methods solely intended for analytical purposes are not within the scope of the journal. Additionally, disciplines such as soil science, polymer science, and metallurgy fall outside the purview of Separation and Purification Technology. Join us in advancing the field of separation and purification methods for sustainable solutions in chemical and environmental engineering.
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