Marine fungi as a goldmine for novel antibiotics: a 2024 perspective

IF 2.8 2区生物学 Q1 MARINE & FRESHWATER BIOLOGY Frontiers in Marine Science Pub Date : 2025-01-21 DOI:10.3389/fmars.2024.1538136

Chengqian Pan, Syed Shams ul Hassan, Ishaq Muhammad, Huizi Jin

引用次数: 0

Abstract

The microbial diversity in oceans is considerable, widely distributed in seawater, marine sediments, and marine organisms. Compared with terrestrial resources in traditional natural product research, the living environments of marine microorganisms are starkly different. The drastic differences in survival conditions, such as high salinity, oligotrophic conditions, lack of light, and limited oxygen, determine that microorganisms exhibit distinctive characteristics in metabolism, survival modes, and adaptive mechanisms. These factors contribute to significant distinctions in secondary metabolic pathways and enzymatic reaction mechanisms between marine and terrestrial microorganisms. In this review, we summarized a total of 72 novel natural products with antibacterial activity, published in 2024, which are derived from marine-derived fungi. These products (polyketides, alkaloids, terpenoids, and peptides) are emphasized in terms of their structures and biological activities. This article aims to provide useful information for the research and development of novel antibiotics.

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海洋真菌作为新型抗生素的金矿：2024年的展望

海洋微生物的多样性相当可观，广泛分布在海水、海洋沉积物和海洋生物中。与传统天然产物研究中的陆地资源相比，海洋微生物的生存环境有着明显的不同。生存条件的巨大差异，如高盐度、少营养条件、缺乏光照和有限氧气，决定了微生物在代谢、生存模式和适应机制方面表现出独特的特征。这些因素导致了海洋和陆地微生物在次生代谢途径和酶促反应机制上的显著差异。本文综述了自2024年以来发表的72种具有抗菌活性的新型天然产物，这些天然产物均来源于海洋真菌。这些产物（聚酮、生物碱、萜类和多肽）在其结构和生物活性方面被强调。本文旨在为新型抗生素的研究和开发提供有益的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Marine Science Agricultural and Biological Sciences-Aquatic Science

CiteScore

5.10

自引率

16.20%

发文量

2443

审稿时长

14 weeks

期刊介绍： Frontiers in Marine Science publishes rigorously peer-reviewed research that advances our understanding of all aspects of the environment, biology, ecosystem functioning and human interactions with the oceans. Field Chief Editor Carlos M. Duarte at King Abdullah University of Science and Technology Thuwal is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, policy makers and the public worldwide. With the human population predicted to reach 9 billion people by 2050, it is clear that traditional land resources will not suffice to meet the demand for food or energy, required to support high-quality livelihoods. As a result, the oceans are emerging as a source of untapped assets, with new innovative industries, such as aquaculture, marine biotechnology, marine energy and deep-sea mining growing rapidly under a new era characterized by rapid growth of a blue, ocean-based economy. The sustainability of the blue economy is closely dependent on our knowledge about how to mitigate the impacts of the multiple pressures on the ocean ecosystem associated with the increased scale and diversification of industry operations in the ocean and global human pressures on the environment. Therefore, Frontiers in Marine Science particularly welcomes the communication of research outcomes addressing ocean-based solutions for the emerging challenges, including improved forecasting and observational capacities, understanding biodiversity and ecosystem problems, locally and globally, effective management strategies to maintain ocean health, and an improved capacity to sustainably derive resources from the oceans.