Bionic synapses for real-time epileptic seizure control

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL Sensors and Actuators B: Chemical Pub Date : 2025-01-22 DOI:10.1016/j.snb.2025.137304

Chen Liu , Yuting Jiang , Xingda Mu , Xuling Chang , Ye Zhang , Xiaoxiao He , Xiaojuan Zhu , Wenbo Sun , Lehui Lu

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Abstract

Real-time optogenetic devices that can intelligently react to abnormal changes in the electrophysiological signals of epilepsy patients are crucial for timely seizure control. Inspired by electrical synapses, we report a bionic synapse built with entirely transparent ionic conductors. This system forms a soft, flexible network that allows free ionic movement, mimicking natural synaptic behavior. The bionic conductive technology is demonstrated in the application for brain signal recording-an emotion detection sensor. We also explore the potential of this technology for use in neural activity detections during optogenetic stimulation and emphasize its advantages in compromising optical recording. Furthermore, we have implemented this device for epileptic seizure control by real-time optogenetic modulation, which offers good potential for brain-machine interfaces in the monitoring and treatment of diseases. Our work highlights the advantages of transparent ionic conductors in combining electrophysiological recording and neural modulation, advancing both neurotechnology and bioelectronics.

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实时控制癫痫发作的仿生突触

能够对癫痫患者电生理信号的异常变化做出智能反应的实时光遗传设备对于及时控制癫痫发作至关重要。受电突触的启发，我们报告了一个完全透明的离子导体构建的仿生突触。这个系统形成了一个柔软、灵活的网络，允许自由的离子运动，模仿自然的突触行为。仿生导电技术在脑信号记录-情绪检测传感器中的应用。我们还探索了该技术在光遗传刺激期间用于神经活动检测的潜力，并强调了其在损害光学记录方面的优势。此外，我们已经实现了该装置通过实时光遗传调制控制癫痫发作，这为监测和治疗疾病的脑机接口提供了良好的潜力。我们的工作突出了透明离子导体在结合电生理记录和神经调节方面的优势，促进了神经技术和生物电子学的发展。

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来源期刊

Sensors and Actuators B: Chemical 工程技术-电化学

CiteScore

14.60

自引率

11.90%

发文量

1776

审稿时长

3.2 months

期刊介绍： Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.