The need for smart microalgal bioprospecting

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2025-01-16 DOI:10.1007/s13659-024-00487-3

Joan Labara Tirado, Andrei Herdean, Peter J. Ralph

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Abstract

Microalgae’s adaptability and resilience to Earth’s diverse environments have evolved these photosynthetic microorganisms into a biotechnological source of industrially relevant physiological functions and biometabolites. Despite this, microalgae-based industries only exploit a handful of species. This lack of biodiversity hinders the expansion of the microalgal industry. Microalgal bioprospecting, searching for novel biological algal resources with new properties, remains a low throughput and time-consuming endeavour due to inefficient workflows that rely on non-selective sampling, monoalgal culture status and outdated, non-standardized characterization techniques. This review will highlight the importance of microalgal bioprospecting and critically explore commonly employed methodologies. We will also explore current advances driving the next generation of smart algal bioprospecting focusing on novel workflows and transdisciplinary methodologies with the potential to enable high-throughput microalgal biodiscoveries. Images adapted from (Addicted04 in Wikipedia File: Australia on the globe (Australia centered).svg. 2014.; Jin et al. in ACS Appl Bio Mater 4:5080–5089, 2021; Kim et al. in Microchim Acta 189:88, 2022; Tony et al. in Lab on a Chip 15, 19:3810–3810; Thermo Fisher Scientific INC. in CTS Rotea Brochure).

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对智能微藻生物勘探的需求

微藻对地球多样化环境的适应性和恢复力使这些光合微生物进化成为与工业相关的生理功能和生物代谢物的生物技术来源。尽管如此，以微藻为基础的工业只开发了少数几种物种。生物多样性的缺乏阻碍了微藻产业的发展。微藻生物勘探，寻找具有新特性的新型生物藻类资源，仍然是一个低通量和耗时的努力，由于低效的工作流程，依赖于非选择性采样，单藻培养状态和过时的，非标准化的表征技术。本文将强调微藻生物勘探的重要性，并对常用的方法进行批判性的探讨。我们还将探讨推动下一代智能藻类生物勘探的当前进展，重点关注新颖的工作流程和跨学科方法，具有实现高通量微藻生物发现的潜力。图片改编自维基百科文件：全球的澳大利亚（以澳大利亚为中心）.svg。2014年。Jin et al. journal of chengdu electromechanical college, 2011；Kim et al. in microchem学报189:88,2022；Tony et al. in Lab on a Chip, 15 (1):3810 - 3810；赛默飞世尔科技有限公司（CTS Rotea手册）。图形抽象

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.