Advancements and Applications of 4D Bioprinting in Biomedical Science

IF 4.1 2区化学 Q2 POLYMER SCIENCE Chinese Journal of Polymer Science Pub Date : 2024-12-25 DOI:10.1007/s10118-025-3259-0

Hakan Eskizengin, Can Ergun

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Abstract

The constraints of traditional 3D bioprinting are overcome by 4D bioprinting integrating with adaptable materials over time, resulting in dynamic, compliant, and functional biological structures. This innovative approach to bioprinting holds great promise for tissue engineering, regenerative medicine, and advanced drug delivery systems. 4D bioprinting is a technology that allows for the extension of 3D bioprinting technology by making predesigned structures change after they are fabricated using smart materials that can alter their characteristics via stimulus, leading to transformation in healthcare, which is able to provide precise personalized effective medical treatment without any side effects. This review article concentrates on some recent developments and applications in the field of 4D bioprinting, which can pave the way for groundbreaking advancements in biomedical sciences. 4D printing is a new chapter in bioprinting that introduces dynamism and functional living biological structures. Therefore, smart materials and sophisticated printing techniques can eliminate the challenges associated with printing complex organs and tissues. However, the problems with this process are biocompatibility, immunogenicity, and scalability, which need to be addressed. Moreover, numerous obstacles have been encountered during its widespread adoption in clinical practice. Therefore, 4D bioprinting requires improvements in future material science innovations and further development in printers and manufacturing techniques to unlock its potential for better patient care and outcomes.

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4D生物打印技术在生物医学中的应用与进展

随着时间的推移，4D生物打印与适应性材料相结合，克服了传统3D生物打印的局限性，产生了动态、顺应性和功能性的生物结构。这种创新的生物打印方法在组织工程、再生医学和先进的药物输送系统方面具有很大的前景。4D生物打印是一项允许3D生物打印技术扩展的技术，通过使用智能材料制造预先设计的结构，可以通过刺激改变其特性，从而导致医疗保健的转变，能够提供精确的个性化有效的医疗治疗，没有任何副作用。本文主要介绍了4D生物打印技术在生物医学领域的一些最新进展和应用，为生物医学科学的突破性发展铺平了道路。4D打印是生物打印的新篇章，介绍了动态和功能性的生物结构。因此，智能材料和复杂的打印技术可以消除打印复杂器官和组织的挑战。然而，这一过程的问题是生物相容性、免疫原性和可扩展性，这需要解决。此外，在临床实践中广泛采用的过程中遇到了许多障碍。因此，4D生物打印需要未来材料科学创新的改进，以及打印机和制造技术的进一步发展，以释放其更好的患者护理和结果的潜力。

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来源期刊

Chinese Journal of Polymer Science 化学-高分子科学

CiteScore

7.10

自引率

11.60%

发文量

218

审稿时长

6.0 months

期刊介绍： Chinese Journal of Polymer Science (CJPS) is a monthly journal published in English and sponsored by the Chinese Chemical Society and the Institute of Chemistry, Chinese Academy of Sciences. CJPS is edited by a distinguished Editorial Board headed by Professor Qi-Feng Zhou and supported by an International Advisory Board in which many famous active polymer scientists all over the world are included. The journal was first published in 1983 under the title Polymer Communications and has the current name since 1985. CJPS is a peer-reviewed journal dedicated to the timely publication of original research ideas and results in the field of polymer science. The issues may carry regular papers, rapid communications and notes as well as feature articles. As a leading polymer journal in China published in English, CJPS reflects the new achievements obtained in various laboratories of China, CJPS also includes papers submitted by scientists of different countries and regions outside of China, reflecting the international nature of the journal.