Sesterterpenoids: sources, structural diversity, biological activity, and data management†

IF 10.6 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Natural Product Reports Pub Date : 2025-01-20 DOI:10.1039/d4np00041b

Valeria Iobbi , Valentina Parisi , Mauro Giacomini , Francesco De Riccardis , Paola Brun , Laura Núñez-Pons , Giuliana Drava , Paolo Giordani , Maria Chiara Monti , Roberto Poggi , Ylenia Murgia , Nunziatina De Tommasi , Angela Bisio

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Abstract

Reviewing the literature published up to October 2024.

Sesterterpenoids are one of the most chemically diverse and biologically promising subgroup of terpenoids, the largest family of secondary metabolites. The present review article summarizes more than seven decades of studies on isolation and characterization of more than 1600 structurally novel sesterterpenoids, supplemented by biological, pharmacological, ecological, and geographic distribution data. All the information have been implemented in eight tables available on the web and a relational database https://sesterterpenoids.unige.net/. The interface has two sections, one open to the public for reading only and the other, protected by an authentication mechanism, for timely updating of published results.

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酯萜类：来源、结构多样性、生物活性和数据管理。

回顾截至2024年10月发表的文献。酯萜类化合物是萜类化合物中化学多样性和生物学前景最广阔的亚群之一，是次生代谢产物中最大的一类。本文综述了七十多年来对1600多种结构新颖的酯萜类化合物的分离和表征的研究，并辅以生物学、药理学、生态学和地理分布的数据。所有信息都在web上的8个表和一个关系数据库https://sesterterpenoids.unige.net/中实现。该接口有两个部分，一个部分对公众开放，仅供阅读，另一个部分由身份验证机制保护，用于及时更新已发布的结果。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.