Interaction between breastfeeding duration and an obesity genetic risk score to predict body fat composition in European adolescents: The HELENA study.

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2025-01-21 DOI:10.1111/ijpo.13205

Georgios K Baxevanis, Iris Iglesia, Miguel Seral-Cortes, Sergio Sabroso-Lasa, Paloma Flores-Barrantes, Frédéric Gottrand, Aline Meirhaeghe, Anthony Kafatos, Kurt Widhalm, Nele Hockamp, Dénes Molnár, Ascensión Marcos, Esther Nova, Marcela González-Gross, Eva Gesteiro, Ángel Gutiérrez, Yannis Manios, Costas A Anastasiou, Gerardo Rodríguez, Luis A Moreno

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Abstract

Background: Although the genetic interplay with the environment has a major impact on obesity development, little is known on whether breastfeeding could modulate the genetic predisposition to obesity.

Objectives: To investigate whether breastfeeding attenuates the effect of an obesity genetic risk score (GRS) on adiposity in European adolescents.

Methods: Totally 751 adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were included, divided according to breastfeeding status into never breastfed, 1-3 months and ≥4 months. Adjusting by socioeconomic status and lifestyle factors multiple linear regression models were used to assess (1) the main effect of breastfeeding duration and (2) its interaction effect with an obesity GRS, to predict different adiposity measures.

Results: A significant negative association between ≥4 months of breastfeeding and waist circumference (WC) z-score was observed [β (95% confidence interval), p-value] = [β = -0.189 (-0.37, -0.00), p = 0.044]. Also, significant interaction effects were observed for 1-3 and ≥4 months of breastfeeding and obesity GRS regarding body mass index (BMI) z-score [β = 0.155 (0.06, 0.24), p = 0.001] and [β = 0.108 (0.01, 0.18), p = 0.020, respectively] and fat mass index (FMI) z-score [β = 0.134 (0.04, 0.22), p = 0.003] and [β = 0.100 (0.01, 0.18), p = 0.026, respectively].

Conclusions: Breastfeeding modulates the association between the obesity GRS and body composition in adolescents.

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在欧洲青少年中，母乳喂养持续时间和肥胖遗传风险评分预测体脂组成的相互作用：HELENA研究。

背景：虽然遗传与环境的相互作用对肥胖的发展有重大影响，但母乳喂养是否能调节肥胖的遗传易感性尚不清楚。目的：研究母乳喂养是否会减弱欧洲青少年肥胖遗传风险评分（GRS）对肥胖的影响。方法：采用欧洲青少年营养健康生活方式（HELENA）横断面研究纳入751名青少年，按母乳喂养状况分为从不母乳喂养、1-3个月和≥4个月。经社会经济地位和生活方式因素调整后，采用多元线性回归模型评估(1)母乳喂养时间的主要影响以及(2)其与肥胖GRS的交互作用，以预测不同的肥胖措施。结果：≥4个月母乳喂养与腰围（WC） z-score呈显著负相关[β（95%可信区间），p值]= [β = -0.189 (-0.37, -0.00), p = 0.044]。此外，1-3个月和≥4个月母乳喂养与肥胖GRS在体重指数（BMI） z-score [β = 0.155 (0.06, 0.24), p = 0.001]和脂肪质量指数（FMI） z-score [β = 0.134 (0.04, 0.22), p = 0.003]和[β = 0.100 (0.01, 0.18), p = 0.026]方面存在显著交互作用。结论：母乳喂养调节了青少年肥胖GRS与体成分的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.