Sleep-disordered breathing and cardiometabolic and inflammatory markers in children with overweight/obesity: The role of cardiorespiratory fitness.

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2025-01-21 DOI:10.1111/ijpo.13207

Lucia V Torres-Lopez, Abel Plaza-Florido, Jose J Gil-Cosano, Jairo H Migueles, Francisco B Ortega, Cristina Cadenas-Sanchez

{"title":"Sleep-disordered breathing and cardiometabolic and inflammatory markers in children with overweight/obesity: The role of cardiorespiratory fitness.","authors":"Lucia V Torres-Lopez, Abel Plaza-Florido, Jose J Gil-Cosano, Jairo H Migueles, Francisco B Ortega, Cristina Cadenas-Sanchez","doi":"10.1111/ijpo.13207","DOIUrl":null,"url":null,"abstract":"Objectives: To investigate the association of sleep-disordered breathing (SDB) severity with cardiometabolic and inflammatory markers independently of the adiposity levels; and to explore the role of cardiorespiratory fitness in these associations in children with overweight/obesity.Methods: A total of 109 children aged 8-11 years with overweight/obesity were included in this cross-sectional study. SDB was assessed using a scale of the reduce version of the Paediatric Sleep Questionnaire. Cardiometabolic markers included fasting blood lipids biomarkers (i.e., low- and high-density lipoprotein cholesterol, and triglycerides), blood pressure, insulin, glucose, and the homeostatic model assessment index. Inflammatory markers (i.e., interleukin-6, interleukin-1β, C-reactive protein [CRP], and tumour necrosis factor alpha) were analysed. Cardiorespiratory fitness was assessed by the 20 m shuttle-run test.Results: No significant associations were found between SDB severity and most of the cardiometabolic markers after correcting for adiposity and multiple comparisons (all p's >0.05). SDB severity was positively related to CRP (β = 0.352, p = 0.002), yet not with the remaining inflammatory markers analysed. The interaction effect of cardiorespiratory fitness presented a positive trend in the association of SDB with CRP (p = 0.1). When stratified analyses by cardiorespiratory fitness levels were conducted, a positive relation was found between SDB and CRP in the low cardiorespiratory fitness group (β = 0.465, p = 0.014), but not in the high cardiorespiratory fitness group (β = 0.236, p = 0.108).Conclusion: SDB severity was positively associated with CRP independently of the adiposity levels, but not with other inflammatory or cardiometabolic risk factors in children with overweight/obesity. Moreover, our results suggest that higher levels of cardiorespiratory fitness may attenuate the adverse effect of SDB severity on systematic inflammation in children with overweight/obesity.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e13207"},"PeriodicalIF":2.7000,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Obesity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ijpo.13207","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: To investigate the association of sleep-disordered breathing (SDB) severity with cardiometabolic and inflammatory markers independently of the adiposity levels; and to explore the role of cardiorespiratory fitness in these associations in children with overweight/obesity.

Methods: A total of 109 children aged 8-11 years with overweight/obesity were included in this cross-sectional study. SDB was assessed using a scale of the reduce version of the Paediatric Sleep Questionnaire. Cardiometabolic markers included fasting blood lipids biomarkers (i.e., low- and high-density lipoprotein cholesterol, and triglycerides), blood pressure, insulin, glucose, and the homeostatic model assessment index. Inflammatory markers (i.e., interleukin-6, interleukin-1β, C-reactive protein [CRP], and tumour necrosis factor alpha) were analysed. Cardiorespiratory fitness was assessed by the 20 m shuttle-run test.

Results: No significant associations were found between SDB severity and most of the cardiometabolic markers after correcting for adiposity and multiple comparisons (all p's >0.05). SDB severity was positively related to CRP (β = 0.352, p = 0.002), yet not with the remaining inflammatory markers analysed. The interaction effect of cardiorespiratory fitness presented a positive trend in the association of SDB with CRP (p = 0.1). When stratified analyses by cardiorespiratory fitness levels were conducted, a positive relation was found between SDB and CRP in the low cardiorespiratory fitness group (β = 0.465, p = 0.014), but not in the high cardiorespiratory fitness group (β = 0.236, p = 0.108).

Conclusion: SDB severity was positively associated with CRP independently of the adiposity levels, but not with other inflammatory or cardiometabolic risk factors in children with overweight/obesity. Moreover, our results suggest that higher levels of cardiorespiratory fitness may attenuate the adverse effect of SDB severity on systematic inflammation in children with overweight/obesity.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

超重/肥胖儿童的睡眠呼吸障碍、心脏代谢和炎症标志物：心肺健康的作用

目的：探讨睡眠呼吸障碍（SDB）严重程度与独立于肥胖水平的心脏代谢和炎症指标的关系；并探讨在超重/肥胖儿童中，心肺健康在这些关联中的作用。方法：本横断面研究共纳入109例8-11岁超重/肥胖儿童。使用儿科睡眠问卷的简化版量表评估SDB。心脏代谢标志物包括空腹血脂生物标志物（即低、高密度脂蛋白胆固醇和甘油三酯）、血压、胰岛素、葡萄糖和稳态模型评估指标。分析炎症标志物（即白细胞介素-6、白细胞介素-1β、c反应蛋白[CRP]和肿瘤坏死因子α）。采用20米穿梭跑试验评价心肺功能。结果：校正肥胖和多重比较后，SDB严重程度与大多数心脏代谢指标之间无显著相关性（p < 0.05）。SDB严重程度与CRP呈正相关（β = 0.352, p = 0.002），但与其余炎症标志物分析无关。在心肺适能的交互作用下，SDB与CRP呈正相关（p = 0.1）。按心肺适能水平分层分析时，低心肺适能组SDB与CRP呈正相关（β = 0.465, p = 0.014），高心肺适能组不呈正相关（β = 0.236, p = 0.108）。结论：在超重/肥胖儿童中，SDB严重程度与CRP呈正相关，独立于肥胖水平，但与其他炎症或心脏代谢危险因素无关。此外，我们的研究结果表明，较高的心肺健康水平可能会减轻SDB严重程度对超重/肥胖儿童系统性炎症的不利影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.