Global impact of PM2.5 on cardiovascular disease: Causal evidence and health inequities across region from 1990 to 2021.

IF 8 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Journal of Environmental Management Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI:10.1016/j.jenvman.2025.124168
Jing-Xuan Zhou, Zi-Yi Zheng, Zhao-Xing Peng, Hong-Gang Ni
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Abstract

PM2.5 is an important environmental risk factor for cardiovascular disease (CVD) and poses a threat to global health. This study combines bibliometric analysis, Mendelian randomization (MR), and Global Burden of Disease (GBD) data to comprehensively explore the relationship between PM2.5 exposure and CVD. MR analyses provided strong evidence for causality, reinforcing findings from traditional observational studies. The estimated global burden of PM2.5-related CVD indicated, that there exist significant impacts on the elderly, men, and populations in low and medium socio-demographic index (SDI) areas. This study further found that population growth and aging are the main drivers of this burden with large inequities, although medical advances have mitigated some of the effects. Overall, the opportunity to reduce the burden of CVD remains significant, particularly in medium SDI countries. Projections to 2045 suggested that the absolute burden will increase, while age-standardized rates will decline due to improvements in air quality and health care. These findings emphasized the urgent need for targeted interventions to mitigate the deleterious effects of PM2.5 on global cardiovascular health and to address health inequalities between regions.

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PM2.5对心血管疾病的全球影响:1990年至2021年各区域的因果证据和卫生不公平现象。
PM2.5是心血管疾病(CVD)的重要环境危险因素,对全球健康构成威胁。本研究结合文献计量学分析、孟德尔随机化(Mendelian randomization, MR)和全球疾病负担(Global Burden of Disease, GBD)数据,全面探讨PM2.5暴露与心血管疾病的关系。核磁共振分析为因果关系提供了强有力的证据,强化了传统观察性研究的发现。估计的全球pm2.5相关心血管疾病负担表明,在老年人、男性和中低社会人口指数(SDI)地区的人群中存在显著影响。这项研究进一步发现,人口增长和老龄化是这种负担的主要驱动因素,存在巨大的不平等,尽管医学进步已经减轻了一些影响。总体而言,减少心血管疾病负担的机会仍然很大,特别是在中等SDI国家。到2045年的预测表明,绝对负担将增加,而由于空气质量和医疗保健的改善,年龄标准化率将下降。这些研究结果强调,迫切需要有针对性的干预措施,以减轻PM2.5对全球心血管健康的有害影响,并解决区域之间的健康不平等问题。
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来源期刊
Journal of Environmental Management
Journal of Environmental Management 环境科学-环境科学
CiteScore
13.70
自引率
5.70%
发文量
2477
审稿时长
84 days
期刊介绍: The Journal of Environmental Management is a journal for the publication of peer reviewed, original research for all aspects of management and the managed use of the environment, both natural and man-made.Critical review articles are also welcome; submission of these is strongly encouraged.
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