Hexagonal Hollow Core PCF-Based Blood Components Sensing: Design and Simulation.

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Cell Biochemistry and Biophysics Pub Date : 2025-01-21 DOI:10.1007/s12013-025-01672-y

Md Alamin Hossain, Md Parash Chowdhury, Md Mahabub Hossain, Mahfujur Rahman, Md Selim Hossain

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Abstract

Blood components play a crucial role in maintaining human health and accurately detecting them is essential for medical diagnostics. A cutting-edge sensor utilizing PCF revealed to precisely identify a wide range of blood components with WBCs (white blood cells), RBCs (red blood cells), HB (hemoglobin), platelets, and plasma. A numerical analysis was performed using COMSOL Multiphysics software to assess the capabilities of the sensor. The sensor design features a hexagonal hollow core-based PCF with a circled air hole operating wavelength from 1.0 μm to 3.0 μm. This innovative PCF sensor exhibits outstanding sensitivity, achieving relative sensitivity values of approximately 97.45% for WBCs, 99.13% for HB, 99.61% for RBCs, 93.44% for plasma, and an impressive 99.42% for platelets, all at a wavelength of 1 μm in its optimized design and this design ensures reliable and highly accurate measurements for various blood components. The corresponding effective areas are 3.32 × 10^-11 m² for WBCs, 2.91 × 10^-11 m² for HB, 2.72 × 10^-11 m² for RBCs, 3.74 × 10^-11 m² for plasma, and 2.79 × 10^-11 m² for platelets, respectively. Furthermore, The sensor demonstrates exceptional performance with remarkably low confinement loss values of 3.032 × 10^-9 dB/m for WBCs, 2.947 × 10^-9 dB/m for HB, 3.147 × 10^-9 dB/m for RBCs, 3.112 × 10^-9 dB/m for plasma, and 3.205 × 10^-9 dB/m for platelets, respectively. Additionally, the effective material loss is 5.43 × 10^-3 cm^-1 for WBCs, 2.19 × 10^-3 cm^-1 for HB, 1.27 × 10^-3 cm^-1 for RBCs, 1.32 × 10^-3 cm^-1 for plasma, and 1.58 × 10^-3 cm^-1 for platelets. Therefore, this biosensor's outstanding sensing capabilities and innovative design make it ideal for industrial and medical applications, ensuring reliability and ease of use. The PCF-based sensor has great potential to transform optical communication applications. Its prosperity model and high sensitivity build it a valued device with the promise of addressing critical challenges in the place of biology, medicine, and communication systems. The sensor features Teflon (tetrafluoroethylene) as its background material, with air holes optimized in a five-ring structure for maximum efficiency and it is the ideal fiber material, offering excellent relative sensitivity and low confinement loss (CL). More than that, 3D printing is the ideal method for fabricating hexagonal hollow-core photonic crystal fiber (PCF) structures, allowing for the effective production of the advanced biosensor design.

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基于六边形空心核pcf的血液成分传感：设计与仿真。

血液成分在维持人体健康中起着至关重要的作用，准确检测血液成分对医学诊断至关重要。利用PCF的尖端传感器揭示了精确识别广泛的血液成分的wbc（白细胞），红细胞（红细胞），HB（血红蛋白），血小板和血浆。使用COMSOL Multiphysics软件进行数值分析，以评估传感器的性能。该传感器设计采用六角形空心芯PCF，环形空气孔工作波长为1.0 μm至3.0 μm。这款创新的PCF传感器具有出色的灵敏度，在1 μm波长下，wbc的相对灵敏度值约为97.45%，HB为99.13%，红细胞为99.61%，血浆为93.44%，血小板为令人印象深刻的99.42%，该设计确保了各种血液成分的可靠和高度精确的测量。相应的有效面积分别为：白细胞3.32 × 10-11 m2, HB 2.91 × 10-11 m2，红细胞2.72 × 10-11 m2，血浆3.74 × 10-11 m2，血小板2.79 × 10-11 m2。此外，该传感器表现出优异的性能，具有非常低的约束损耗值，分别为wbc的3.032 × 10-9 dB/m、HB的2.947 × 10-9 dB/m、红细胞的3.147 × 10-9 dB/m、血浆的3.112 × 10-9 dB/m和血小板的3.205 × 10-9 dB/m。此外，白细胞的有效物质损失为5.43 × 10-3 cm-1，血红蛋白为2.19 × 10-3 cm-1，红细胞为1.27 × 10-3 cm-1，血浆为1.32 × 10-3 cm-1，血小板为1.58 × 10-3 cm-1。因此，这种生物传感器出色的传感能力和创新的设计使其成为工业和医疗应用的理想选择，确保了可靠性和易用性。基于pcf的传感器在改变光通信应用方面具有巨大的潜力。它的繁荣模式和高灵敏度使其成为一种有价值的设备，有望解决生物、医学和通信系统领域的关键挑战。该传感器以聚四氟乙烯（四氟乙烯）为背景材料，其气孔在五环结构中进行了优化，以实现最高效率，是理想的纤维材料，具有出色的相对灵敏度和低约束损耗（CL）。更重要的是，3D打印是制造六方空心光子晶体光纤（PCF）结构的理想方法，可以有效地生产先进的生物传感器设计。

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来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.