Genetic and structural factors contributing to the dominance and persistence of goose astrovirus type 2.

IF 2.5 2区 农林科学 Q1 VETERINARY SCIENCES Avian Pathology Pub Date : 2025-02-05 DOI:10.1080/03079457.2025.2454416
Peng Jiang, Aolin Li, Hongfu Ma, Yankun Lan, Jiaguo Wang, Xin Wang, Liang Zhao, Qifei Wu, Yong Wang, Xu Guo
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Abstract

Research highlights: Goose astrovirus type 2 (GoAstV-2) became the dominant strain in China post-2017.GoAstV-2 exhibits weaker codon usage bias, enhancing adaptability across hosts.The stability of GoAstV-2 spike protein reduces mutation needs and selective pressure.GoAstV-2 low spike protein variability supports long-term persistence in host populations.

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鹅星状病毒2型显性和持久性的遗传和结构因素。
鹅星状病毒(GoAstV)已成为影响中国鹅业的重要病原体,自2017年以来,GoAstV-2成为主导基因型。本研究探讨了GoAstV-2流行的遗传和结构因素,重点关注密码子使用偏差、刺突蛋白变异和结构稳定性。系统发育和有效种群大小分析显示,GoAstV-2在2017年至2018年期间经历了快速扩张,随后种群稳定。密码子使用分析表明,与GoAstV-1相比,GoAstV-2表现出较弱的密码子使用偏见,这表明GoAstV-2在同音密码子使用上具有更大的灵活性,并可能增强宿主环境之间的适应性。此外,GoAstV-2较低的密码子适应指数值表明其与宿主的最佳密码子使用存在差异,这可能会减少与宿主tRNA池的竞争,从而促进病毒复制。Shannon熵分析表明,GoAstV-2的穗蛋白变异性明显低于GoAstV-1,表明GoAstV-2具有更强的结构稳定性。这种稳定性可能会减少频繁突变的需要,从而允许GoAstV-2在宿主种群中持续存在,而无需持续进化。较低的抗原性变异性可能降低了免疫驱动的选择压力,有助于病毒的持续传播和长期存在。这些发现为了解GoAstV-2的进化优势及其在流行病学上的成功提供了新的见解,可以为未来旨在减轻其对家禽种群影响的控制策略提供信息。
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来源期刊
Avian Pathology
Avian Pathology 农林科学-兽医学
CiteScore
4.50
自引率
10.70%
发文量
68
审稿时长
1 months
期刊介绍: Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.
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