Change in Metabolic Markers and the Risk of Skin Cancer: Results from the Lifelines Cohort Study in the Netherlands.

IF 3.4 3区医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2025-04-03 DOI:10.1158/1055-9965.EPI-24-1235

Michael Shimelash, Grigory Sidorenkov, Bert van der Vegt, Mathilde Jalving, Emöke Rácz, Geertruida H de Bock

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Abstract

Background: Skin cancers are the most common cancers in Caucasians, and their incidence is rising. Although metabolic and anthropometric markers play a role in cancer development, the relationship between metabolic and anthropometric changes in skin cancer remains unclear. This study aimed to examine possible associations between these changes and the risk of skin cancer.

Methods: Participants without prior skin cancer history from the Northern Netherlands representative of the general population were included. Histopathology data were obtained from the Dutch Nationwide Pathology Database. Adjusted Cox regression analyzed associations between metabolic changes and time to pathology-confirmed skin cancer incidence over a 7-year follow-up, assessing overall skin cancer risk and subtypes, including melanoma and nonmelanoma skin cancer.

Results: Out of 97,106 participants, 4,195 (4.3%) developed skin cancer. Decrease and increase in body mass index (BMI) were both associated with lower skin cancer risk: adjusted HRs (aHR) of 0.88 (0.80-0.98) and 0.78 (0.72-0.86), respectively. Triglyceride and waist-to-hip ratio decreases were also associated with lower risk: aHR: 0.89 (0.80-0.98) and 0.89 (0.83-0.98), respectively. Increase in Hemoglobin A1c (HbA1c) was associated with a higher risk in individuals below the age of 45 years at baseline: aHR: 1.21 (1.01-1.45). Subtype analysis showed an increase in BMI was associated with lower melanoma risk: aHR: 0.72 (0.58-0.91).

Conclusions: Changes in BMI and decrease in triglycerides and waist-to-hip ratio are related to lower skin cancer risk, whereas an increase in HbA1c may elevate risk in individuals younger than 45 at baseline. These findings highlight the importance of non-sunlight-related risk factors for skin cancer prevention and the need for further research into underlying mechanisms.

Impact: This study contributes to the broader understanding of how metabolic health impacts skin cancer development, offering potential avenues for targeted prevention strategies.

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代谢标志物的变化和皮肤癌的风险：来自荷兰生命线队列研究的结果

背景：皮肤癌是白种人中最常见的癌症，其发病率呈上升趋势。虽然代谢和人体测量标志物在癌症发展中发挥作用，但代谢和人体测量变化与皮肤癌的关系尚不清楚。这项研究旨在研究这些变化与皮肤癌风险之间可能存在的联系。方法：没有皮肤癌病史的参与者来自荷兰北部的一般人群代表。组织病理学数据来自荷兰全国病理数据库。校正cox回归分析了7年随访期间代谢变化与病理证实的皮肤癌发病率之间的关系，评估了总体皮肤癌风险和亚型，包括黑色素瘤和非黑色素瘤皮肤癌。结果：在97106名参与者中，4195人（4.3%）患上了皮肤癌。身体质量指数（BMI）的降低和增加都与较低的皮肤癌风险相关：调整危险比（aHR）分别为0.88（0.80-0.98）和0.78（0.72-0.86）。甘油三酯和腰臀比（WHR）的降低也与较低的风险相关：aHR分别为0.89（0.80-0.98）和0.89（0.83-0.98）。基线时45岁以下人群HbA1c升高与高风险相关：aHR: 1.21（1.01-1.45）。亚型分析显示，BMI增加与黑色素瘤风险降低相关：aHR: 0.72（0.58-0.91）。结论：BMI的变化、甘油三酯和WHR的降低与皮肤癌风险降低有关，而HbA1c的升高可能会升高基线年龄小于45岁的个体的风险。这些发现强调了非阳光相关的风险因素对皮肤癌预防的重要性，以及对潜在机制进行进一步研究的必要性。影响：这项研究有助于更广泛地了解代谢健康如何影响皮肤癌的发展，为有针对性的预防策略提供潜在的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.