{"title":"The cochlea phenotypically differs from the vestibule in the Gfi1<sup>GFP/GFP</sup> mouse.","authors":"Zhuo Li, Hongzhi Chen, Hao Feng","doi":"10.1002/dvdy.772","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Previous studies with Gfi1-mutated lines have shown that Gfi1 is essential for hair cell maturation and survival.</p><p><strong>Results: </strong>We analyzed the phenotype of another Gfi1-mutated line Gfi1<sup>GFP/GFP</sup> in the inner ears of neonates at P5-7 and found that the cochlea phenotypically differed from the vestibule in the Gfi1<sup>GFP/GFP</sup> mouse. Specifically, there was a marked reduction in hair cells in the cochlea, which was characterized by greater reductions in the outer hair cells but far less reductions (mainly in the basal turn) in the inner hair cells, whereas the vestibular hair cells remained unaffected. These results were consistent with findings from previous studies. Unexpectedly, the number of cochlear non-sensory supporting cells significantly decreased. However, the vestibular supporting cells did not demonstrate any abnormalities in number.</p><p><strong>Conclusion: </strong>Gfi1 exhibits different functions in the cochlea and vestibule during inner ear development.</p>","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Dynamics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/dvdy.772","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Previous studies with Gfi1-mutated lines have shown that Gfi1 is essential for hair cell maturation and survival.
Results: We analyzed the phenotype of another Gfi1-mutated line Gfi1GFP/GFP in the inner ears of neonates at P5-7 and found that the cochlea phenotypically differed from the vestibule in the Gfi1GFP/GFP mouse. Specifically, there was a marked reduction in hair cells in the cochlea, which was characterized by greater reductions in the outer hair cells but far less reductions (mainly in the basal turn) in the inner hair cells, whereas the vestibular hair cells remained unaffected. These results were consistent with findings from previous studies. Unexpectedly, the number of cochlear non-sensory supporting cells significantly decreased. However, the vestibular supporting cells did not demonstrate any abnormalities in number.
Conclusion: Gfi1 exhibits different functions in the cochlea and vestibule during inner ear development.
期刊介绍：
Developmental Dynamics, is an official publication of the American Association for Anatomy. This peer reviewed journal provides an international forum for publishing novel discoveries, using any model system, that advances our understanding of development, morphology, form and function, evolution, disease, stem cells, repair and regeneration.
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