Sex-specific ultrasound imaging biomarkers of neurodegeneration in a mouse model.

IF 4.1 2区医学 Q2 GERIATRICS & GERONTOLOGY Frontiers in Aging Neuroscience Pub Date : 2025-01-07 eCollection Date: 2024-01-01 DOI:10.3389/fnagi.2024.1445164

Mark B Russell, Drew P Locke, Haley M Adams, Alexander R Pelley, Rojan Saghian, Alexandre S Maekawa, Darcie Stapleton, Grace V Mercer, John G Sled, Lindsay S Cahill

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Abstract

Introduction: Early detection of neurodegeneration is essential for optimizing interventions. The highly reproducible progression of neurodegeneration in the decrepit (dcr) mouse allows investigation of early biomarkers and mechanisms of brain injury.

Methods: Using high-frequency ultrasound, the common carotid arteries of female and male dcr and control mice were imaged longitudinally at time points bracketing the disease progression (50, 75, and 125 days of age) (n = 6 mice/group/sex).

Results: Over the disease time course, the female dcr mice demonstrated increased carotid artery blood flow and pulse wave velocity while the male dcr mice had a decrease in heart rate and no change in carotid artery ultrasound parameters. Early imaging biomarkers were sex-specific, with decreased carotid artery blood flow in female dcr mice and increased carotid artery diameter and decreased pulse wave velocity in males.

Discussion: Carotid artery and wave reflection ultrasound is a promising screening tool for early detection of neurodegeneration.

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小鼠神经退行性变模型的性别特异性超声成像生物标志物。

简介：神经退行性疾病的早期发现对于优化干预措施至关重要。在衰老（dcr）小鼠中高度可重复的神经退行性进展使得研究早期生物标志物和脑损伤机制成为可能。方法：采用高频超声，在疾病进展前后时间点（50、75、125日龄）对雌性、雄性dcr小鼠和对照组的颈总动脉进行纵向成像（n = 6只/组/性别）。结果：随着疾病时间的推移，雌性dcr小鼠颈动脉血流量和脉搏波速度增加，而雄性dcr小鼠心率下降，颈动脉超声参数无变化。早期成像生物标志物具有性别特异性，雌性dcr小鼠颈动脉血流量减少，雄性dcr小鼠颈动脉直径增加，脉搏波速度降低。讨论：颈动脉和波反射超声是一种很有前途的早期检测神经变性的筛查工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.