Novel serum biomarkers for early diagnosis of gestational diabetes mellitus-a review.

IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-01-21 DOI:10.1080/09513590.2025.2455472
Michał Kunicki, Natalia Rzewuska, Paulina Sopońska, Agata Pawłosek, Iwona Sowińska, Anna Kloska
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Abstract

Gestational diabetes mellitus (GDM) affects 9-25% of pregnancies. Undiagnosed or poorly managed GDM is associated with both short- and long-term complications in the fetus and mother. The pathogenesis of GDM is complex and has not yet been fully elucidated. Several biomarkers found in maternal serum have the potential for the early diagnosis of GDM. The aim of this narrative review was to explore novel biomarkers that have not been comprehensively described in previous reviews. We believe these biomarkers may allow for the detection of GDM in the early stages of pregnancy, enabling timely proper treatment and potentially preventing complications for both the mother and the fetus.

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早期诊断妊娠期糖尿病的新型血清生物标志物综述
妊娠期糖尿病(GDM)影响9-25%的妊娠。未确诊或管理不善的GDM与胎儿和母亲的短期和长期并发症有关。GDM的发病机制复杂,尚未完全阐明。在母体血清中发现的几种生物标志物具有早期诊断GDM的潜力。这篇叙述性综述的目的是探索在以前的综述中没有全面描述的新型生物标志物。我们相信这些生物标记物可以在妊娠早期检测到GDM,使母亲和胎儿能够及时得到适当的治疗,并有可能预防并发症。
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来源期刊
Gynecological Endocrinology
Gynecological Endocrinology 医学-妇产科学
CiteScore
4.40
自引率
5.00%
发文量
137
审稿时长
3-6 weeks
期刊介绍: Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction
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