Commentary: towards a national research infrastructure strategy for preclinical biological models in Australia.

IF 2.7 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Mammalian Genome Pub Date : 2025-03-01 Epub Date: 2025-01-20 DOI:10.1007/s00335-024-10103-x
James E Hennessy, Sarah Nisbet, Michael S Dobbie
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Abstract

Research infrastructure is critical for advancing knowledge of health and disease, fostering innovation through world-class, cutting-edge facilities and technical expertise. Phenomics Australia is Australia's national research infrastructure provider responsible for accelerating advances in mammalian functional genomics and precision medicine through the development and delivery of services and expertise in engineered disease model production, phenotyping, and biobanking. These capabilities and resources are enabled by Australia's National Collaborative Research Infrastructure Strategy and primarily support health and medical research for significant healthcare and economic benefits. Priorities identified in the Australian Government's 2021 National Research Infrastructure Roadmap include the development and expansion of capabilities in digital research infrastructure, improved research translation, and enhanced management of biological collections, which are strongly aligned with Phenomics Australia's strategy to develop and enable access to high-quality national genetics resources at scale. Here, we comment on Phenomics Australia's response to these national strategy imperatives and the critical role of preclinical biological models research infrastructure in Australia.

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评论:朝着澳大利亚临床前生物学模型的国家研究基础设施战略。
研究基础设施对于增进健康和疾病知识、通过世界一流的尖端设施和技术专长促进创新至关重要。澳大利亚表型组学是澳大利亚国家研究基础设施提供商,负责通过开发和提供工程疾病模型生产、表型分析和生物银行方面的服务和专业知识,加速哺乳动物功能基因组学和精准医学的进步。这些能力和资源是由澳大利亚国家合作研究基础设施战略提供的,主要支持卫生和医学研究,以获得重大的医疗保健和经济效益。澳大利亚政府2021年国家研究基础设施路线图确定的优先事项包括发展和扩大数字研究基础设施的能力,改进研究翻译,加强生物收集管理,这与澳大利亚表型组学公司大规模开发和获取高质量国家遗传资源的战略高度一致。在这里,我们评论了澳大利亚表型组学对这些国家战略要求的反应,以及澳大利亚临床前生物学模型研究基础设施的关键作用。
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来源期刊
Mammalian Genome
Mammalian Genome 生物-生化与分子生物学
CiteScore
4.00
自引率
0.00%
发文量
33
审稿时长
6-12 weeks
期刊介绍: Mammalian Genome focuses on the experimental, theoretical and technical aspects of genetics, genomics, epigenetics and systems biology in mouse, human and other mammalian species, with an emphasis on the relationship between genotype and phenotype, elucidation of biological and disease pathways as well as experimental aspects of interventions, therapeutics, and precision medicine. The journal aims to publish high quality original papers that present novel findings in all areas of mammalian genetic research as well as review articles on areas of topical interest. The journal will also feature commentaries and editorials to inform readers of breakthrough discoveries as well as issues of research standards, policies and ethics.
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