Non-coding RNAs in urinary bladder cancer microenvironment: Diagnostic, therapeutic, and prognostic perspective.

IF 2.9 4区医学 Q2 PATHOLOGY Pathology, research and practice Pub Date : 2025-01-09 DOI:10.1016/j.prp.2025.155815

Enas A El Saftawy, Basma Emad Aboulhoda, Marwa Ali AbdElkhalek, Mansour A Alghamdi, Nashwah Samir AlHariry

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Abstract

Urinary bladder cancer (UBC) is the ninth most common cancer worldwide. Despite the reliance of UBC therapy on definite pathological grading and classifications, the clinical response among patients varies widely. The molecular basis of this type of cancer appeals to considerable research; hence, new diagnostic and therapeutic options are introduced. Convenient keywords were searched in Google Scholar, PubMed, the Egyptian Knowledge Bank (EKB), and Web of Science. The recent era of UBC research is concerned with non-coding RNAs (ncRNAs), predominantly, microRNAs (miRNAs) and long non-coding RNA (lncRNAs). In addition, snoRNAs, PIWI-interacting RNAs, mitochondrial RNAs, circular, and Schistosoma haematobium-related ncRNAs appeared to contribute to the pathogenesis of the UBC. This review underscored the recently studied ncRNAs and their importance in the pathogenesis of UBC. Besides, we introduced the prospectives regarding their diagnostic, therapeutic, and prognostic significance in UBC clinical settings. Conclusion. Oncogenic and oncosuppressor ncRNAs' definite balances and interaction within the TME of UBC are key players in the fate of the tumor. Thus, profiling ncRNA in-depth inspects the TME of the UBC for better clinical insights.

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膀胱癌微环境中的非编码rna：诊断、治疗和预后的观点。

膀胱癌（UBC）是全球第九大常见癌症。尽管UBC治疗依赖于明确的病理分级和分类，但患者的临床反应差异很大。这类癌症的分子基础需要大量的研究；因此，新的诊断和治疗方案被引入。在b谷歌Scholar， PubMed, Egyptian Knowledge Bank （EKB）和Web of Science中搜索了方便的关键词。最近UBC的研究主要关注非编码RNA (ncRNAs)，主要是微RNA （miRNAs）和长链非编码RNA （lncRNAs）。此外，snoRNAs、piwi相互作用的rna、线粒体rna、环状rna和血血吸虫相关的ncRNAs似乎与UBC的发病机制有关。这篇综述强调了最近研究的ncrna及其在UBC发病机制中的重要性。此外，我们还介绍了它们在UBC临床环境中的诊断、治疗和预后意义。结论。在UBC的TME中，致癌和抑癌ncrna的明确平衡和相互作用是肿瘤命运的关键参与者。因此，分析ncRNA深入检查UBC的TME以获得更好的临床见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.