Cognitive-Behavioral Intervention for Children With Hematological Cancer Receiving Chemotherapy: A Randomized Controlled Trial.

IF 3.3 2区医学 Q2 ONCOLOGY Psycho‐Oncology Pub Date : 2025-01-01 DOI:10.1002/pon.70086

Tenaw Gualu Melesse, William Ho Cheung Li, Janita Pak Chun Chau, Mulugeta Ayalew Yimer, Abdulkadir Mohamedsaid Gidey, Sewbesew Yitayih

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Abstract

Objective: Cognitive-behavioral intervention (CBI) has shown positive effects in improving psychological and health-related outcomes in children with cancer. However, no evidence has been found in Ethiopia. This study aimed to evaluate the effects of CBI on anxiety, depression and quality of life (QoL) in Ethiopian children with hematological cancer receiving chemotherapy.

Methods: A parallel, two-armed, assessor-blinded, randomized controlled trial was conducted among 76 children randomized (1:1) to receive CBI or usual medical care. The intervention group received five weekly face-to-face CBI sessions of 30-40 min each, which included an introduction to CBI; identifying and challenging maladaptive thoughts, beliefs and behavior; behavior activation; deep breathing exercises; and treatment evaluation and relapse prevention. The outcomes were measured at baseline (T0), immediately post-intervention (T1) and 1 month post-intervention (T2).

Results: The intervention group showed a significant reduction in anxiety scores from T0 at T1 (β = -6.67, 95% CI [-9.16, -4.19], p < 0.001) and T2 (β = -8.14, 95% CI [-10.70, -5.57], p < 0.001), depression at T1 (β = -4.09, 95% CI [-6.94, -1.23], p = 0.005) and T2 (β = -6.12, 95% CI [-9.10, -3.13], p < 0.001) and improvement in QoL at T2 (β = 3.02, 95% CI [0.49, 5.56], p = 0.019) compared with the control group.

Conclusions: CBI has positive effects in reducing anxiety and depression and in improving QoL in children with hematological cancer receiving chemotherapy. The results suggest the need to incorporate CBI into pediatric hematology-oncology and studies on its long-term effects and cost-effectiveness are warranted.

Trial registration: ClinicalTrials.gov (NCT05270655). Registered on 08 March 2022.

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接受化疗的儿童血液癌患者的认知行为干预：一项随机对照试验。

目的：认知行为干预（CBI）在改善儿童癌症患者的心理和健康相关结局方面显示出积极作用。然而，在埃塞俄比亚没有发现任何证据。本研究旨在评估CBI对接受化疗的埃塞俄比亚血液病儿童的焦虑、抑郁和生活质量的影响。方法：对76名接受CBI或常规医疗护理的儿童进行平行、双臂、评估盲、随机对照试验（1:1）。干预组每周接受5次面对面的CBI课程，每次30-40分钟，包括对CBI的介绍；识别和挑战不适应的想法、信念和行为；行为激活;深呼吸练习；治疗评价和复发预防。在基线（T0）、干预后立即（T1）和干预后1个月（T2）测量结果。结果：干预组在T1时焦虑评分较T0显著降低（β = -6.67, 95% CI [-9.16, -4.19], p）。结论：CBI对减轻血液癌化疗患儿的焦虑和抑郁，改善生活质量有积极作用。结果表明，有必要将CBI纳入儿科血液学肿瘤学，并对其长期效果和成本效益进行研究。试验注册：ClinicalTrials.gov （NCT05270655）。2022年3月8日注册

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来源期刊

Psycho‐Oncology 医学-心理学

CiteScore

6.30

自引率

8.30%

发文量

220

审稿时长

3-8 weeks

期刊介绍： Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology. This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues. Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.