Evolutionary analysis of a coupled epidemic-voluntary vaccination behavior model with immunity waning on complex networks.

Abstract

Vaccination is the most effective method of preventing and controlling the transmission of infectious diseases within populations. However, the phenomenon of waning immunity can induce periodic fluctuations in epidemic spreading. This study proposes a coupled epidemic-vaccination dynamic model to analyze the influence of immunity waning on the epidemic spreading within the context of voluntary vaccination. First, we establish an SIRSV (susceptible-infected-recovered-susceptible-vaccinated) compartment model to describe the transmission mechanism of infectious diseases based on the mean-field theory. Within this model, we incorporate a nonlinear infection rate with network topology and consider the waning natural and vaccine-induced immunity at the individual level. The evolutionary model of voluntary vaccination strategy is integrated into the SIRSV model to characterize the impact of vaccination behavior on the infectious disease transmission. We also consider two individual risk assessment methods, namely, the individual-based risk assessment (IB-RA) method and the society-based risk assessment (SB-RA) method, originating from local and global perspectives, respectively. Then, utilizing the next-generation matrix method, we derive the time-varying effective reproduction numbers of the model. Also, the theoretical analysis of optimal strategy thresholds in the individual decision-making process is also conducted. The results indicate that the thresholds obtained from the agent-based model (ABM) simulation method are consistent with the theoretical analysis, demonstrating the effectiveness of our model. Finally, we apply the coupled model to the COVID-19 pandemic in France, Germany, Italy, and the United Kingdom. This study analyzes the impact of waning immunity and provides early warning for the outbreak of the epidemics.