Quantification of the Anterior-Centripetal Movement of the Ciliary Muscle During Accommodation Using Dynamic OCT Imaging.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY Translational Vision Science & Technology Pub Date : 2025-01-02 DOI:10.1167/tvst.14.1.17

Iulen Cabeza-Gil, Marco Ruggeri, Fabrice Manns

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Abstract

Purpose: Although the lens undoubtedly plays a major role in presbyopia, altered lens function could be in part secondary to age-related changes of the ciliary muscle. Ciliary muscle changes with accommodation have been quantified using optical coherence tomography, but so far these studies have been limited to quantifying changes in ciliary muscle thickness, mostly at static accommodative states. Quantifying ciliary muscle thickness changes does not effectively capture the dynamic anterior-centripetal movement of the ciliary muscle during accommodation. To address this issue, we present a method to quantify the movement of the ciliary muscle during accommodation using trans-scleral optical coherence tomography images obtained dynamically.

Methods: An image processing framework including distortion correction, geometric transformation, and Procrustes analysis, was used to quantify the anterior-centripetal movement of the ciliary muscle apex and centroid during accommodation. The method was applied in a preliminary study to quantify ciliary muscle displacement and its relation to lens thickness change with accommodation on two young adults and two prepresbyopes.

Results: The magnitude and the direction relative to the pupil plane of the apex/centroid displacement in response to a two diopters (2D) stimulus were 0.16/0.20 mm at 11.3°/30.5° and 0.26/0.34 mm at 6.6°/33.2° for the young adults and 0.20/0.20 mm at 29.7°/40.6° and 0.24/0.40 mm at 33.0°/31.7° for the prepresbyopes, respectively.

Conclusions: This study demonstrates the feasibility of quantifying dynamic anterior-centripetal movement of the ciliary muscle during accommodation using optical coherence tomography. The method better captures the functional response of the muscle than the quantification of thickness changes.

Translational relevance: We provide a method that holds potential to better understand the age-related changes of the ciliary muscle on presbyopia.

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动态OCT成像量化调节过程中睫状肌的前向心运动。

虽然晶状体无疑在老花眼中起着重要作用，但晶状体功能的改变可能部分是继发于睫状肌的年龄相关变化。睫状肌随调节的变化已经使用光学相干断层扫描进行了量化，但到目前为止，这些研究仅限于量化睫状肌厚度的变化，主要是在静态调节状态下。量化纤毛肌厚度的变化并不能有效地捕捉到调节过程中纤毛肌的动态前向心运动。为了解决这个问题，我们提出了一种方法来量化睫状肌在调节过程中的运动，使用动态获得的经巩膜光学相干断层扫描图像。方法：采用畸变校正、几何变换和Procrustes分析等图像处理框架，量化调节过程中睫状肌顶点和质心的前向心运动。该方法应用于两名青壮年和两名前老花眼的睫状肌位移及其与晶状体厚度随调节变化的关系的初步研究。结果：在两种屈光度（2D）刺激下，青壮年在11.3°/30.5°和6.6°/33.2°刺激下，眼尖/质心相对于瞳面位移的大小和方向分别为0.16/0.20 mm和0.26/0.34 mm；老花眼在29.7°/40.6°刺激下，眼尖/质心相对于瞳面位移的大小和方向分别为0.20/0.20 mm和0.24/0.40 mm。结论：本研究证明了使用光学相干断层扫描量化调节过程中睫状肌前向运动的可行性。该方法比量化厚度变化更能捕捉肌肉的功能反应。翻译相关性：我们提供了一种具有潜力的方法，可以更好地了解老花眼中睫状肌的年龄相关变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.