The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis.

IF 4 3区医学 Q2 VIROLOGY Virology Journal Pub Date : 2025-01-20 DOI:10.1186/s12985-024-02612-7

Shayan Mardi, Maryam Rashidian, Fatemeh Bastan, Ghazale Molaverdi, Sayed-Hamidreza Mozhgani

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Abstract

Background: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that leads to lifelong infection and multiple diseases, including HAM/TSP and ATLL. Despite extensive research, the exact pathophysiology of HTLV infection and its related diseases is enigmatic. In this study, we aimed to review and analyze the effect of different HLA alleles as protective or predisposing factors in HTLV-1 infection and its progression to related diseases.

Method: Three databases (PubMed, Web of Science, and Scopus) were searched for eligible studies. Twenty-five papers with 7279 participants were included in the quantitative analysis. The relevant data were extracted, and 198 meta-analyses were conducted on each reported HLA and population.

Results: The results of our investigation suggest 3 HLAs with preventive effects against HTLV infection, including HLA-B*35, DRB1*09, and DRB1*16. Also, HLA-DQB1*05:01 might prevent HTLV progression to ATLL. In contrast, HLA-DRB1*13 is more prevalent in ATLL patients than HTLV carriers. Additionally, our results propound that carriers of HLA-A*28, B*54, C*07, DQB1*03:01, and DRB1*07:01 are at higher risk, and carriers of HLA-A*30, B*37, B*40, B*44, C*08, DQB1*06:02, and DRB1*15:01 are in lower risk of HTLV progression to HAM/TSP. We concluded that the mentioned HLA alleles are potential biomarkers of HTLV infection and its progression to related diseases.

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人白细胞抗原在HTLV-1感染和ATLL和HAM/TSP进展中的作用：一项系统回顾和荟萃分析

背景：人t细胞嗜淋巴病毒1型（HTLV-1）是一种可导致终身感染和多种疾病的逆转录病毒，包括HAM/TSP和ATLL。尽管研究广泛，但HTLV感染及其相关疾病的确切病理生理机制仍是一个谜。在本研究中，我们旨在回顾和分析不同HLA等位基因在HTLV-1感染及其相关疾病进展中的保护或易感因素的作用。方法：检索PubMed、Web of Science和Scopus三个数据库，寻找符合条件的研究。定量分析纳入25篇论文，7279名受试者。提取相关数据，对每个报告的HLA和人群进行198次meta分析。结果：3种hla抗体对HTLV感染具有预防作用，分别为HLA-B*35、DRB1*09和DRB1*16。此外，HLA-DQB1*05:01可能阻止HTLV发展为ATLL。相比之下，HLA-DRB1*13在ATLL患者中比HTLV携带者更普遍。同时，HLA-A*28、B*54、C*07、DQB1*03:01、DRB1*07:01基因携带者HTLV发展为HAM/TSP的风险较高，HLA-A*30、B*37、B*40、B*44、C*08、DQB1*06:02、DRB1*15:01基因携带者HTLV发展为HAM/TSP的风险较低。我们的结论是，上述HLA等位基因是HTLV感染及其相关疾病进展的潜在生物标志物。

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来源期刊

Virology Journal 医学-病毒学

CiteScore

7.40

自引率

2.10%

发文量

186

审稿时长

1 months

期刊介绍： Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.