[Clinicopathological significance and prognostic value of serum 25-hydroxyvitamin D₃ level in children with IgA vasculitis nephritis].

Q3 Medicine 中国当代儿科杂志 Pub Date : 2025-01-15 DOI:10.7499/j.issn.1008-8830.2408058

Pao Yu, Pei Zhang, Chun-Lin Gao, Zi Wang, Yin Zhang, Zheng Ge, Bi Zhou

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Abstract

Objectives: To study the significance of serum 25-hydroxyvitamin D₃ [25-(OH)D₃] level in the clinicopathological characteristics and prognosis of children with immunoglobulin A vasculitis nephritis (IgAVN).

Methods: A retrospective analysis was conducted on the clinical data of children with IgAVN who underwent renal biopsy at Suzhou Hospital Affiliated to Anhui Medical University and Jinling Hospital of the Medical School of Nanjing University from June 2015 to June 2020. Based on serum 25-(OH)D₃ level, the patients were divided into a normal group and a lower group. The clinicopathological characteristics and follow-up data of the two groups were collected and compared.

Results: A total of 359 children with IgAVN were included. Compared to the normal group (62 cases), the lower group (297 cases) exhibited higher incidences of hematochezia and gross hematuria, higher levels of serum creatinine, blood urea nitrogen, urinary retinol protein, urinary N-acetyl-β-D-glucosaminidase, and quantitative urinary protein, and a longer duration from renal biopsy to urinary protein becoming negative, as well as lower estimated glomerular filtration rate and albumin level (P<0.05). Renal pathology in the lower group showed a higher occurrence of tubular interstitial injury, crescent formation, segmental sclerosis in glomeruli, and inflammatory cell infiltration in the renal interstitium compared to the normal group (P<0.05). Survival analysis indicated that the cumulative renal survival rate was lower in the lower group (P<0.05). Multivariate Cox regression analysis revealed that low serum 25-(OH)D₃ level is an independent risk factor for poor prognosis in children with IgAVN.

Conclusions: Children with IgAVN and low serum 25-(OH)D₃ level have relatively severe clinicopathological manifestations. Low serum 25-(OH)D₃ level is an independent risk factor for poor prognosis in children with IgAVN.

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[血清25-羟基维生素D3水平在IgA血管炎肾炎患儿中的临床病理意义及预后价值]。

目的：探讨血清25-羟基维生素D3 [25-(OH)D3]水平在免疫球蛋白A血管性肾炎（IgAVN）患儿临床病理特征及预后中的意义。方法：回顾性分析2015年6月至2020年6月在安徽医科大学附属苏州医院和南京大学医学院附属金陵医院行IgAVN患儿肾活检的临床资料。根据血清25-(OH)D3水平将患者分为正常组和低水平组。收集两组患者的临床病理特征及随访资料进行比较。结果：共纳入IgAVN患儿359例。与正常组（62例）相比，低剂量组（297例）出现了更高的便血和血尿发生率，血清肌酐、血尿素氮、尿视黄醇蛋白、尿n -乙酰-β- d -氨基葡萄糖苷酶、尿定量蛋白水平较高，且从肾活检到尿蛋白变为阴性的时间较长。以及较低的肾小球滤过率和白蛋白水平（PPP3水平）是IgAVN患儿预后不良的独立危险因素。结论：IgAVN患儿血清25-(OH)D3水平低，临床病理表现较重。血清25-(OH)D3水平低是IgAVN患儿预后不良的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.