A pilot and feasibility study investigating the abundance and activity of nitrate-reducing bacteria in women with pre-eclampsia.

IF 2.5 4区医学 Q2 OBSTETRICS & GYNECOLOGY Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health Pub Date : 2025-01-14 DOI:10.1016/j.preghy.2025.101188

Lisa du Toit, Ifeoma Offiah, Alvaro Redondo-Rio, Tanya Kahawita, Michele Kiernan, Yen Ming Lin, Louise Belfield, Gemma Montagut, Alicia Benavente, Tomas Nicholas, Amazon Doble, Renske Dikkers, Robert Freeman, Toni Gabaldón, Zoe Brookes, Raul Bescos

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Abstract

Background: Oral health may influence blood pressure control by modulating the abundance and activity of nitrate-reducing bacteria, which are essential for enhancing nitrite and nitric oxide (NO) bioavailability. This study aimed to investigate the oral health and microbiome composition of women with pre-eclampsia (PET) compared to healthy controls (CN).

Methods: Ten PET and eleven CN women participated in this study, respectively. An oral health examination was conducted in all the participants. Saliva and blood samples were collected for analysis of the oral microbiome and NO biomarkers.

Results: Higher plaque levels were observed in the PET group compared to the CN group (P = 0.038). The relative abundance of oral bacteria at the genus level did not differ between groups, however, the activity of oral nitrate-reducing bacteria (P = 0.088) and salivary nitrite levels (P = 0.100) appeared lower in the PET group, though not statistically significant. Plasma nitrate levels were significantly lower in the PET group compared to the CN group (P = 0.024).

Conclusion: Women with PET showed poorer oral health and potential lower activity of nitrate-reducing bacteria and salivary nitrite, indicating a need for further investigation into treatments targeting oral health and the microbiome in women with PET.

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一个试点和可行性研究调查丰度和活性的硝酸盐减少细菌妇女先兆子痫。

背景：口腔健康可能通过调节硝酸盐还原菌的丰度和活性来影响血压控制，而硝酸盐还原菌对于提高亚硝酸盐和一氧化氮（NO）的生物利用度至关重要。本研究旨在探讨子痫前期妇女（PET）与健康对照组（CN）的口腔健康和微生物组组成。方法：10例PET妇女和11例CN妇女分别参加本研究。所有参与者都进行了口腔健康检查。收集唾液和血液样本，分析口腔微生物组和NO生物标志物。结果：PET组斑块水平高于CN组（P = 0.038）。口腔细菌在属水平上的相对丰度在各组间无显著差异，但口腔硝酸盐还原菌活性（P = 0.088）和唾液亚硝酸盐水平（P = 0.100）在PET组有所降低，但无统计学意义。PET组血浆硝酸盐水平明显低于CN组（P = 0.024）。结论：接受PET的女性口腔健康状况较差，硝酸盐还原细菌和唾液亚硝酸盐的活性可能较低，这表明需要进一步研究针对PET女性口腔健康和微生物组的治疗方法。

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来源期刊

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health OBSTETRICS & GYNECOLOGYPERIPHERAL VASCULAR-PERIPHERAL VASCULAR DISEASE

CiteScore

4.90

自引率

0.00%

发文量

127

期刊介绍： Pregnancy Hypertension: An International Journal of Women''s Cardiovascular Health aims to stimulate research in the field of hypertension in pregnancy, disseminate the useful results of such research, and advance education in the field. We publish articles pertaining to human and animal blood pressure during gestation, hypertension during gestation including physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy. The subtitle reflects the wider aspects of studying hypertension in pregnancy thus we also publish articles on in utero programming, nutrition, long term effects of hypertension in pregnancy on cardiovascular health and other research that helps our understanding of the etiology or consequences of hypertension in pregnancy. Case reports are not published unless of exceptional/outstanding importance to the field.