Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health最新文献

Letter to the editor: Barriers and facilitators for adequate calcium intake during pregnancy: A mixed methods study 致编辑的信：怀孕期间摄入充足钙的障碍和促进因素：一项混合方法研究。

IF 2.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Pub Date : 2026-01-12 DOI: 10.1016/j.preghy.2026.101414

Mehak Kumari, Ausaf Ahmed

引用次数: 0

Cardiovascular effects of extra virgin olive oil in healthy reproductive-aged women: a randomized controlled trial 特级初榨橄榄油对健康育龄妇女心血管的影响：一项随机对照试验。

IF 2.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Pub Date : 2026-01-10 DOI: 10.1016/j.preghy.2025.101411

Erin A. Morris , Carole A. McBride , Lorinda Roberts , Rachel Psoinos , Joan Skelly , Maurizio Mandalà , Ira M. Bernstein

Objectives

Pregnant patients with cardiovascular and metabolic risk factors are at increased risk of hypertension in pregnancy. Adherence to Mediterranean-based diets high in extra virgin olive oil (EVOO) is associated with decreased risk. We performed a randomized, double-blind placebo-controlled trial of EVOO supplementation in reproductive-aged women to investigate its effects on cardiovascular function and markers of metabolic dysfunction and inflammation.

Study Design

Healthy nulliparous women were randomized to 40 g/day of EVOO high in oleic acid and phenols or an identical dose of sunflower seed oil for 8 weeks. Cardiovascular assessment, lipid profiles, insulin sensitivity and serum cytokines were assessed at baseline and post intervention.

Main outcome measures

Blood pressure, vessel distensibility, metabolic assessment, serum cytokine levels.

Results

Twelve women in the EVOO group and 15 in the control group completed the trial. Compliance was >97 % in both groups. EVOO supplementation reduced fasting insulin (−0.31 ± 0.52 U/mL, p = 0.03), but increased LDL cholesterol (+5.1 ± 4.0 mg/dL, p = 0.047). No differences in blood pressure were observed, though EVOO was associated with a lower blood pressure response to volume challenge and a trend toward lower hemoglobin A1c (p = 0.06). IL-10 decreased in EVOO but increased in controls, −0.05 ± 0.03 vs +0.07 ± 0.03, p = 0.01). Unique to the EVOO group, a reduction in the chemokine MCP-1 positively correlated with a reduction in systolic blood pressure (r = 0.59, p = 0.042) and MAP (r = 0.59, p = 0.042).

Conclusions

EVOO supplementation in women of reproductive age may have beneficial metabolic and anti-inflammatory effects.

目的：有心血管及代谢危险因素的孕妇妊娠期高血压风险增高。坚持以地中海为基础的高特级初榨橄榄油（EVOO）的饮食与降低风险有关。我们在育龄妇女中进行了一项随机、双盲、安慰剂对照试验，以研究EVOO补充剂对心血管功能、代谢功能障碍和炎症标志物的影响。研究设计：健康的未生育妇女被随机分配到40克/天的高油酸和酚的EVOO或相同剂量的葵花籽油，持续8周。在基线和干预后评估心血管评估、脂质谱、胰岛素敏感性和血清细胞因子。主要观察指标：血压、血管扩张、代谢评估、血清细胞因子水平。结果：EVOO组12名妇女完成试验，对照组15名妇女完成试验。两组患者的依从性均为97%。补充EVOO降低了空腹胰岛素（-0.31±0.52 U/mL, p = 0.03），但增加了LDL胆固醇（+5.1±4.0 mg/dL, p = 0.047）。没有观察到血压的差异，尽管EVOO与较低的血压对容量挑战的反应和较低的血红蛋白A1c趋势相关（p = 0.06）。EVOO组IL-10降低，对照组升高（-0.05±0.03 vs +0.07±0.03,p = 0.01）。EVOO组特有的趋化因子MCP-1的降低与收缩压（r = 0.59, p = 0.042）和MAP （r = 0.59, p = 0.042）的降低呈正相关。结论：育龄妇女补充EVOO可能具有有益的代谢和抗炎作用。

{"title":"Cardiovascular effects of extra virgin olive oil in healthy reproductive-aged women: a randomized controlled trial","authors":"Erin A. Morris , Carole A. McBride , Lorinda Roberts , Rachel Psoinos , Joan Skelly , Maurizio Mandalà , Ira M. Bernstein","doi":"10.1016/j.preghy.2025.101411","DOIUrl":"10.1016/j.preghy.2025.101411","url":null,"abstract":"<div><h3>Objectives</h3><div>Pregnant patients with cardiovascular and metabolic risk factors are at increased risk of hypertension in pregnancy. Adherence to Mediterranean-based diets high in extra virgin olive oil (EVOO) is associated with decreased risk. We performed a randomized, double-blind placebo-controlled trial of EVOO supplementation in reproductive-aged women to investigate its effects on cardiovascular function and markers of metabolic dysfunction and inflammation.</div></div><div><h3>Study Design</h3><div>Healthy nulliparous women were randomized to 40 g/day of EVOO high in oleic acid and phenols or an identical dose of sunflower seed oil for 8 weeks. Cardiovascular assessment, lipid profiles, insulin sensitivity and serum cytokines were assessed at baseline and post intervention.</div></div><div><h3>Main outcome measures</h3><div>Blood pressure, vessel distensibility, metabolic assessment, serum cytokine levels.</div></div><div><h3>Results</h3><div>Twelve women in the EVOO group and 15 in the control group completed the trial. Compliance was >97 % in both groups. EVOO supplementation reduced fasting insulin (−0.31 ± 0.52 U/mL, p = 0.03), but increased LDL cholesterol (+5.1 ± 4.0 mg/dL, p = 0.047). No differences in blood pressure were observed, though EVOO was associated with a lower blood pressure response to volume challenge and a trend toward lower hemoglobin A1c (p = 0.06). IL-10 decreased in EVOO but increased in controls, −0.05 ± 0.03 vs +0.07 ± 0.03, p = 0.01). Unique to the EVOO group, a reduction in the chemokine MCP-1 positively correlated with a reduction in systolic blood pressure (r = 0.59, p = 0.042) and MAP (r = 0.59, p = 0.042).</div></div><div><h3>Conclusions</h3><div>EVOO supplementation in women of reproductive age may have beneficial metabolic and anti-inflammatory effects.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"43 ","pages":"Article 101411"},"PeriodicalIF":2.9,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal electrocardiographic and hemodynamic parameters in fetal growth restriction: a case control study 胎儿生长受限的母体心电图和血流动力学参数：一项病例对照研究

IF 2.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Pub Date : 2026-01-09 DOI: 10.1016/j.preghy.2025.101412

Burcu Bozkurt Ozdal , Ayse Seval Ozgu-Erdınc , Nursen Ozen , Ayse Altındıs Bal , Gulnihal Reyhan Toptas , Fatma Doga Ocal , Dilek Sahin

Aim

This study investigates relationships between maternal ECG parameters, blood pressure, and FGR, and evaluates their potential as FGR predictors.

Materials and methods

A case-control study was performed between April and July 2025. We enrolled 183 pregnant women (32–37 weeks): 68 with FGR and 115 controls. Maternal demographic, clinical, ECG, and blood pressure data were collected and analyzed.

Results

FGR mothers had lower heart rates, longer QTc and PR intervals, higher RR intervals, and higher systolic and diastolic blood pressures than controls (p < 0.05). QTc, SBP, DBP, MAP, and FGR were positively correlated. Regression analysis found that prolonged QTc and higher systolic blood pressure were significantly associated with FGR risk. ROC analysis yielded moderate sensitivity and specificity for QTc (413 ms), heart rate (81.5 bpm), SBP (110.5 mmHg), and DBP (61.0 mmHg).

Conclusion

Our results show exploratory associations between maternal ECG/blood pressure markers and FGR at 32–37 weeks in a single center. With modest predictive value (AUC 0.64–0.73), these findings do not yet justify clinical screening use. Multicenter studies are needed for validation.

目的探讨产妇心电图参数、血压与FGR的关系，并评价其作为FGR预测指标的潜力。材料与方法于2025年4月~ 7月进行病例对照研究。我们招募了183名孕妇（32-37周）：68名FGR组和115名对照组。收集和分析产妇人口统计、临床、心电图和血压数据。结果fgr组母亲心率较低，QTc和PR间期较长，RR间期较高，收缩压和舒张压高于对照组（p < 0.05）。QTc、SBP、DBP、MAP、FGR呈正相关。回归分析发现，QTc延长和收缩压升高与FGR风险显著相关。ROC分析显示，QTc （413 ms）、心率（81.5 bpm）、收缩压（110.5 mmHg）和舒张压（61.0 mmHg）具有中等的敏感性和特异性。结论我们的研究结果显示，在单中心孕32-37周时，产妇ECG/血压指标与FGR之间存在探索性关联。由于预测价值适中（AUC 0.64-0.73），这些发现尚不能证明临床筛查的应用。需要多中心研究来验证。

{"title":"Maternal electrocardiographic and hemodynamic parameters in fetal growth restriction: a case control study","authors":"Burcu Bozkurt Ozdal , Ayse Seval Ozgu-Erdınc , Nursen Ozen , Ayse Altındıs Bal , Gulnihal Reyhan Toptas , Fatma Doga Ocal , Dilek Sahin","doi":"10.1016/j.preghy.2025.101412","DOIUrl":"10.1016/j.preghy.2025.101412","url":null,"abstract":"<div><h3>Aim</h3><div>This study investigates relationships between maternal ECG parameters, blood pressure, and FGR, and evaluates their potential as FGR predictors.</div></div><div><h3>Materials and methods</h3><div>A case-control study was performed between April and July 2025. We enrolled 183 pregnant women (32–37 weeks): 68 with FGR and 115 controls. Maternal demographic, clinical, ECG, and blood pressure data were collected and analyzed.</div></div><div><h3>Results</h3><div>FGR mothers had lower heart rates, longer QTc and PR intervals, higher RR intervals, and higher systolic and diastolic blood pressures than controls (p < 0.05). QTc, SBP, DBP, MAP, and FGR were positively correlated. Regression analysis found that prolonged QTc and higher systolic blood pressure were significantly associated with FGR risk. ROC analysis yielded moderate sensitivity and specificity for QTc (413 ms), heart rate (81.5 bpm), SBP (110.5 mmHg), and DBP (61.0 mmHg).</div></div><div><h3>Conclusion</h3><div>Our results show exploratory associations between maternal ECG/blood pressure markers and FGR at 32–37 weeks in a single center. With modest predictive value (AUC 0.64–0.73), these findings do not yet justify clinical screening use. Multicenter studies are needed for validation.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"43 ","pages":"Article 101412"},"PeriodicalIF":2.9,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertensive disorders of pregnancy and retinopathy of prematurity in extremely preterm infants: A causal mediation analysis 妊娠高血压疾病与极早产儿视网膜病变：因果中介分析

IF 2.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Pub Date : 2026-01-07 DOI: 10.1016/j.preghy.2025.101410

Satoru Katsuki , Takafumi Ushida , Masahiro Nakatochi , Yumiko Kobayashi , Sho Tano , Seiko Matsuo , Kenji Imai , Yoshiaki Sato , Masahiro Hayakawa , Hiroaki Kajiyama , Tomomi Kotani , on behalf of the Neonatal Research Network of Japan

Objectives

Consensus has not been reached regarding the association between hypertensive disorders of pregnancy (HDP) and retinopathy of prematurity (ROP) in preterm infants. We aimed to clarify the effect of HDP on the risk of ROP based on causal mediation analysis using a population-based database from the Neonatal Research Network of Japan.

Study design

A retrospective study was performed using clinical data of 11,798 infants born at less than 28 weeks of gestation between 2003 and 2017 (HDP group: n = 1,615, non-HDP group: n = 10,183).

Main outcome measures

Causal mediation analysis was performed to decomposes the total effect into the mediated (indirect) and non-mediated (direct) effects of HDP on treated ROP and severe ROP after adjusting for covariates while evaluating fetal growth restriction (birthweight Z-score) as a mediator.

Results

The incidences of treated ROP and severe ROP in the HDP and non-HDP groups were 32.4% vs. 36.0% and 4.1% vs. 6.3%, respectively. The total, direct, and indirect effects of HDP on treated ROP, expressed as risk ratio with 95% confidence interval (CI), were 1.043, (95% CI 0.955–1.124), 0.913 (0.832–0.996), and 1.142 (1.102–1.183), respectively. The total, direct, and indirect effects of HDP on severe ROP were 0.845 (95% CI 0.645–1.086), 0.684 (0.511–0.892), and 1.234 (1.105–1.387), respectively.

Conclusion

Maternal HDP has a direct protective effect against ROP in extremely preterm infants, whereas fetal growth restriction acts as a pathway that indirectly increases the risk of ROP. The overall effect of HDP on ROP appears to be neutral as these opposing effects offset each other.

目的关于妊娠期高血压疾病（HDP）与早产儿视网膜病变（ROP）之间的关系尚未达成共识。我们的目的是利用日本新生儿研究网络基于人群的数据库，基于因果中介分析，阐明HDP对ROP风险的影响。研究设计：回顾性研究采用2003年至2017年11798例妊娠小于28周的婴儿的临床资料（HDP组：n = 1615，非HDP组：n = 10183）。主要结局指标：在评估胎儿生长限制（出生体重z分数）作为中介后，进行因果中介分析，将总效应分解为HDP对治疗性ROP和重度ROP的介导（间接）和非介导（直接）效应。结果HDP组和非HDP组治疗性ROP和重度ROP的发生率分别为32.4%比36.0%和4.1%比6.3%。HDP对治疗后ROP的总、直接和间接影响，以95%可信区间（CI）的风险比表示，分别为1.043 （95% CI 0.955-1.124）、0.913（0.832-0.996）和1.142（1.102-1.183）。HDP对严重ROP的总影响、直接影响和间接影响分别为0.845 （95% CI 0.645-1.086）、0.684（0.511-0.892）和1.234（1.105-1.387）。结论母体HDP对极早产儿ROP具有直接保护作用，而胎儿生长受限是间接增加ROP发生风险的途径。HDP对ROP的总体影响似乎是中性的，因为这些相反的影响相互抵消。

{"title":"Hypertensive disorders of pregnancy and retinopathy of prematurity in extremely preterm infants: A causal mediation analysis","authors":"Satoru Katsuki , Takafumi Ushida , Masahiro Nakatochi , Yumiko Kobayashi , Sho Tano , Seiko Matsuo , Kenji Imai , Yoshiaki Sato , Masahiro Hayakawa , Hiroaki Kajiyama , Tomomi Kotani , on behalf of the Neonatal Research Network of Japan","doi":"10.1016/j.preghy.2025.101410","DOIUrl":"10.1016/j.preghy.2025.101410","url":null,"abstract":"<div><h3>Objectives</h3><div>Consensus has not been reached regarding the association between hypertensive disorders of pregnancy (HDP) and retinopathy of prematurity (ROP) in preterm infants. We aimed to clarify the effect of HDP on the risk of ROP based on causal mediation analysis using a population-based database from the Neonatal Research Network of Japan.</div></div><div><h3>Study design</h3><div>A retrospective study was performed using clinical data of 11,798 infants born at less than 28 weeks of gestation between 2003 and 2017 (HDP group: n = 1,615, non-HDP group: n = 10,183).</div></div><div><h3>Main outcome measures</h3><div>Causal mediation analysis was performed to decomposes the total effect into the mediated (indirect) and non-mediated (direct) effects of HDP on treated ROP and severe ROP after adjusting for covariates while evaluating fetal growth restriction (birthweight Z-score) as a mediator.</div></div><div><h3>Results</h3><div>The incidences of treated ROP and severe ROP in the HDP and non-HDP groups were 32.4% vs. 36.0% and 4.1% vs. 6.3%, respectively. The total, direct, and indirect effects of HDP on treated ROP, expressed as risk ratio with 95% confidence interval (CI), were 1.043, (95% CI 0.955–1.124), 0.913 (0.832–0.996), and 1.142 (1.102–1.183), respectively. The total, direct, and indirect effects of HDP on severe ROP were 0.845 (95% CI 0.645–1.086), 0.684 (0.511–0.892), and 1.234 (1.105–1.387), respectively.</div></div><div><h3>Conclusion</h3><div>Maternal HDP has a direct protective effect against ROP in extremely preterm infants, whereas fetal growth restriction acts as a pathway that indirectly increases the risk of ROP. The overall effect of HDP on ROP appears to be neutral as these opposing effects offset each other.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"43 ","pages":"Article 101410"},"PeriodicalIF":2.9,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Fibrinogen-to-Albumin Ratio and Pre-Eclampsia: A Retrospective Cohort Study 纤维蛋白原与白蛋白比值与子痫前期的关系：一项回顾性队列研究

IF 2.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Pub Date : 2026-01-03 DOI: 10.1016/j.preghy.2025.101413

L. Shang, E. Echevarria, Y. Ouyang, Y. Beilin, D. Katz

Background

Preeclampsia is a leading cause of maternal and fetal morbidity and mortality, but cost-effective, accessible biomarkers remain limited. The fibrinogen-to-albumin ratio (FAR) is a promising inflammatory marker but has not been thoroughly evaluated in diverse populations for its association with preeclampsia.

Methods

We conducted a retrospective cohort analysis of 3,249 patients who delivered at a large academic center in New York City between March 2018 and February 2024. Patients were categorized as control (N = 2,216), preeclampsia without severe features (PE; N = 716), and preeclampsia with severe features (sPE; N = 317). Demographic, clinical, and laboratory characteristics were analyzed. Univariate and multivariate analysis with stepwise AIC selection assessed associations between FAR and preeclampsia. Discriminatory performance was evaluated using area under the curve.

Results

FAR was significantly higher in PE groups compared to controls (P < 0.001). Univariate analysis showed significant associations between FAR and any PE (PE + sPE) (OR 25.2, 95 % CI: 6.63–95.82, P < 0.001) and sPE (OR 8.69, 95 % CI: 1.20–62.66, P = 0.032). In multivariate analysis, FAR was independently associated with PE (OR 6.16, 95 % CI: 1.49–25.56, P = 0.012), but not sPE (OR 2.42, 95 % CI: 0.29–18.89, P = 0.924). FAR alone had modest discriminatory power, which improved when combined with other clinical variables.

Conclusions

FAR is independently associated with preeclampsia and may assist clinicians in risk stratification and perioperative planning at labor admission. Prospective, multicenter studies are needed for further validation.

背景子痫前期是孕产妇和胎儿发病和死亡的主要原因，但具有成本效益、可获得的生物标志物仍然有限。纤维蛋白原与白蛋白比率（FAR）是一种很有前景的炎症标志物，但尚未在不同人群中对其与先兆子痫的关系进行彻底评估。方法：我们对2018年3月至2024年2月在纽约市一家大型学术中心分娩的3249例患者进行了回顾性队列分析。患者分为对照组（N = 2216）、无严重特征子痫前期（PE, N = 716）和有严重特征子痫前期（sPE, N = 317）。分析了人口统计学、临床和实验室特征。单因素和多因素分析采用逐步AIC选择评估FAR和先兆子痫之间的关联。采用曲线下面积法评价判别性表现。结果PE组的far明显高于对照组（P < 0.001）。单因素分析显示FAR与任何PE (PE + sPE) （OR 25.2, 95% CI: 6.63-95.82, P < 0.001）和sPE （OR 8.69, 95% CI: 1.20-62.66, P = 0.032）之间存在显著相关性。在多变量分析中，FAR与PE独立相关（OR 6.16, 95% CI: 1.49-25.56, P = 0.012），但与sPE无关（OR 2.42, 95% CI: 0.29-18.89, P = 0.924）。FAR单独具有适度的区分力，当结合其他临床变量时，这种区分力得到改善。结论far与子痫前期独立相关，可帮助临床医生在分娩入院时进行风险分层和围手术期计划。需要前瞻性的多中心研究来进一步验证。

{"title":"Relationship Between Fibrinogen-to-Albumin Ratio and Pre-Eclampsia: A Retrospective Cohort Study","authors":"L. Shang, E. Echevarria, Y. Ouyang, Y. Beilin, D. Katz","doi":"10.1016/j.preghy.2025.101413","DOIUrl":"10.1016/j.preghy.2025.101413","url":null,"abstract":"<div><h3>Background</h3><div>Preeclampsia is a leading cause of maternal and fetal morbidity and mortality, but cost-effective, accessible biomarkers remain limited. The fibrinogen-to-albumin ratio (FAR) is a promising inflammatory marker but has not been thoroughly evaluated in diverse populations for its association with preeclampsia.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort analysis of 3,249 patients who delivered at a large academic center in New York City between March 2018 and February 2024. Patients were categorized as control (N = 2,216), preeclampsia without severe features (PE; N = 716), and preeclampsia with severe features (sPE; N = 317). Demographic, clinical, and laboratory characteristics were analyzed. Univariate and multivariate analysis with stepwise AIC selection assessed associations between FAR and preeclampsia. Discriminatory performance was evaluated using area under the curve.</div></div><div><h3>Results</h3><div>FAR was significantly higher in PE groups compared to controls (P < 0.001). Univariate analysis showed significant associations between FAR and any PE (PE + sPE) (OR 25.2, 95 % CI: 6.63–95.82, P < 0.001) and sPE (OR 8.69, 95 % CI: 1.20–62.66, P = 0.032). In multivariate analysis, FAR was independently associated with PE (OR 6.16, 95 % CI: 1.49–25.56, P = 0.012), but not sPE (OR 2.42, 95 % CI: 0.29–18.89, P = 0.924). FAR alone had modest discriminatory power, which improved when combined with other clinical variables.</div></div><div><h3>Conclusions</h3><div>FAR is independently associated with preeclampsia and may assist clinicians in risk stratification and perioperative planning at labor admission. Prospective, multicenter studies are needed for further validation.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"43 ","pages":"Article 101413"},"PeriodicalIF":2.9,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The sFlt-1/PlGF ratio test for suspected preeclampsia: an economic assessment in the Netherlands sFlt-1/PlGF比值检测疑似子痫前期：荷兰的经济评估

IF 2.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Pub Date : 2025-12-27 DOI: 10.1016/j.preghy.2025.101409

E.J. Lodewijks , M.L.E. Hendrix , J.A.P. Bons , S. Al-Nasiry , H.C.J. Scheepers

Objective

This study aims to assess the economic impact of using the sFlt-1/PlGF ratio test in addition to standard care in women with suspected preeclampsia in a simulated cohort at Maastricht UMC in the Netherlands.

Study design.

A decision tree model was developed to analyze the costs associated with introducing the sFlt-1/PlGF test. A theoretical cohort of 180 pregnant women with suspected preeclampsia was exposed to the test scenario, in which the sFlt-1/PlGF test was used in addition to current clinical practice, and to the no-testing scenario, in which clinical management was based on current clinical practice. Patient stratification into low-/intermediate- and high-intensity management groups was derived from the methodology used in the PROGNOSIS study, a non-interventional study for women with suspicion of preeclampsia. Follow-up and hospitalization length were derived from retrospective data, and costs were obtained from the Dutch Healthcare Authority. A sensitivity analysis tested the model’s robustness, focusing on cost savings per patient as the primary outcome.

Main outcome measures.

Cost savings in euros for suspected preeclampsia patients and annual savings.

Results

Integration of the sFlt-1/PlGF ratio in clinical practice is projected to generate an annual cost savings of €119 625 for Maastricht UMC. This is equivalent to €664 per patient, representing a cost reduction of 11.05 % in the test scenario compared to the no-testing scenario.

Conclusions

Adopting the sFlt-1/PlGF ratio test for women with suspected preeclampsia is expected to result in cost savings in the Maastricht UMC. This can be explained by improved diagnostic accuracy and reduction of unnecessary hospitalization.

目的：本研究旨在评估在荷兰马斯特里赫特UMC的模拟队列中，在疑似子痫前期妇女的标准治疗之外，使用sFlt-1/PlGF比率测试的经济影响。研究设计。开发了一个决策树模型来分析引入sFlt-1/PlGF测试的相关成本。180名疑似子痫前期孕妇的理论队列被暴露在测试场景中，在当前临床实践的基础上使用sFlt-1/PlGF测试，以及不测试场景中，临床管理基于当前临床实践。患者分为低/中/高强度管理组的方法来源于预后研究中使用的方法，这是一项针对怀疑有子痫前期妇女的非介入性研究。随访和住院时间来自回顾性数据，费用来自荷兰卫生保健管理局。敏感性分析测试了模型的稳健性，重点关注每位患者的成本节约作为主要结果。主要结果测量。为疑似子痫前期患者节省欧元成本和每年节省费用。结果：在临床实践中整合sFlt-1/PlGF比率预计将为马斯特里赫特UMC每年节省119625欧元的成本。这相当于每位患者664欧元，与不进行测试的情况相比，测试情况下的成本降低了11.05%。结论对疑似子痫前期妇女采用sFlt-1/PlGF比值检测有望节省马斯特里赫特UMC的费用。这可以通过提高诊断准确性和减少不必要的住院来解释。

{"title":"The sFlt-1/PlGF ratio test for suspected preeclampsia: an economic assessment in the Netherlands","authors":"E.J. Lodewijks , M.L.E. Hendrix , J.A.P. Bons , S. Al-Nasiry , H.C.J. Scheepers","doi":"10.1016/j.preghy.2025.101409","DOIUrl":"10.1016/j.preghy.2025.101409","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to assess the economic impact of using the sFlt-1/PlGF ratio test in addition to standard care in women with suspected preeclampsia in a simulated cohort at Maastricht UMC in the Netherlands.</div><div>Study design.</div><div>A decision tree model was developed to analyze the costs associated with introducing the sFlt-1/PlGF test. A theoretical cohort of 180 pregnant women with suspected preeclampsia was exposed to the test scenario, in which the sFlt-1/PlGF test was used in addition to current clinical practice, and to the no-testing scenario, in which clinical management was based on current clinical practice. Patient stratification into low-/intermediate- and high-intensity management groups was derived from the methodology used in the PROGNOSIS study, a non-interventional study for women with suspicion of preeclampsia. Follow-up and hospitalization length were derived from retrospective data, and costs were obtained from the Dutch Healthcare Authority. A sensitivity analysis tested the model’s robustness, focusing on cost savings per patient as the primary outcome.</div><div>Main outcome measures.</div><div>Cost savings in euros for suspected preeclampsia patients and annual savings.</div></div><div><h3>Results</h3><div>Integration of the sFlt-1/PlGF ratio in clinical practice is projected to generate an annual cost savings of €119 625 for Maastricht UMC. This is equivalent to €664 per patient, representing a cost reduction of 11.05 % in the test scenario compared to the no-testing scenario.</div></div><div><h3>Conclusions</h3><div>Adopting the sFlt-1/PlGF ratio test for women with suspected preeclampsia is expected to result in cost savings in the Maastricht UMC. This can be explained by improved diagnostic accuracy and reduction of unnecessary hospitalization.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"43 ","pages":"Article 101409"},"PeriodicalIF":2.9,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary angiotensin II and angiotensin-(1–7) in gestational hypertension and preeclampsia subtypes: clinical and biochemical correlations 尿血管紧张素II和血管紧张素-(1-7)在妊娠期高血压和子痫前期亚型中的临床和生化相关性

IF 2.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Pub Date : 2025-12-23 DOI: 10.1016/j.preghy.2025.101407

Caio Ribeiro Vieira Leal , Jessica Diniz Pereira , Heloisa Botezelli , Júlia Fernandes do Carmo Las Casas , Ana Cristina Simões e Silva , Fernando M. Reis

Objective

To evaluate and compare urinary concentrations of Ang II and Ang-(1–7) among women with PE, GH, and normotensive pregnant controls, and to explore associations between these peptides and clinical/laboratory parameters in subtypes of PE.

Methods

This was a cross-sectional study involving 53 women with PE (classified as severe or non-severe and early- or late-onset), 33 with GH and 53 normotensive pregnant controls. Urinary levels of Ang II and Ang-(1–7) were measured using ELISA kits. Group comparisons were performed using non-parametric statistical tests. Correlation analyses were conducted using Spearman or Pearson coefficients, with significance set at p < 0.05.

Results

There were no statistically significant differences in urinary Ang II, Ang-(1–7) or their ratio when comparing PE, GH and controls. However, women with severe PE exhibited significantly higher urinary Ang II levels and Ang II/Ang-(1–7) ratios than those with non-severe PE. In early-onset PE, urinary Ang-(1–7) was positively correlated with creatinine (r = 0.62, p = 0.04) and lactate dehydrogenase levels (r = 0.67, p = 0.02) and the Ang II/Ang-(1–7) ratio correlated strongly with platelet count (r = 0.80, p < 0.001). In late-onset PE, urinary Ang II and its ratio with Ang-(1–7) correlated positively with aspartate aminotransferase (AST) and alanine transaminase, while Ang-(1–7) showed an inverse correlation with AST.

Conclusion

Although overall urinary angiotensin levels did not differ, severe PE presented elevated Ang II and Ang II/Ang-(1–7) ratio, suggesting a local shift towards the classical Ang II-mediated pathway in the most severe disease. Furthermore, distinct correlation patterns, such as angiotensins linked to renal and hematologic markers in early-onset PE and to hepatic enzymes in late-onset PE, support different underlying pathophysiological profiles between these subtypes.

目的：评估和比较PE、GH和正常妊娠对照女性尿中Ang II和Ang-(1-7)的浓度，并探讨这些肽与PE亚型临床/实验室参数之间的关系。方法：这是一项横断面研究，涉及53名PE患者（分为严重或非严重，早发或晚发），33名GH患者和53名血压正常的孕妇对照。采用ELISA试剂盒检测尿中Ang II和Ang-(1-7)水平。采用非参数统计检验进行组间比较。采用Spearman或Pearson系数进行相关分析，显著性设为p。结果：PE、GH与对照组比较，尿Ang II、Ang-(1-7)及其比值无统计学差异。然而，与非严重PE患者相比，严重PE患者尿中Ang II水平和Ang II/Ang-(1-7)比值明显更高。早发性PE患者尿Ang-(1-7)与肌酐水平（r = 0.62, p = 0.04）、乳酸脱氢酶水平（r = 0.67, p = 0.02）呈正相关，Ang II/Ang-(1-7)比值与血小板计数密切相关（r = 0.80, p）。结论：尽管尿血管紧张素水平总体上没有差异，但严重PE患者尿Ang II和Ang II/Ang-(1-7)比值升高，提示在最严重的PE中，Ang II介导的经典途径向局部转移。此外，不同的相关模式，如早发性PE与肾脏和血液标志物相关的血管紧张素，以及晚发性PE与肝酶相关的血管紧张素，支持了这些亚型之间不同的潜在病理生理特征。

{"title":"Urinary angiotensin II and angiotensin-(1–7) in gestational hypertension and preeclampsia subtypes: clinical and biochemical correlations","authors":"Caio Ribeiro Vieira Leal , Jessica Diniz Pereira , Heloisa Botezelli , Júlia Fernandes do Carmo Las Casas , Ana Cristina Simões e Silva , Fernando M. Reis","doi":"10.1016/j.preghy.2025.101407","DOIUrl":"10.1016/j.preghy.2025.101407","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate and compare urinary concentrations of Ang II and Ang-(1–7) among women with PE, GH, and normotensive pregnant controls, and to explore associations between these peptides and clinical/laboratory parameters in subtypes of PE.</div></div><div><h3>Methods</h3><div>This was a cross-sectional study involving 53 women with PE (classified as severe or non-severe and early- or late-onset), 33 with GH and 53 normotensive pregnant controls. Urinary levels of Ang II and Ang-(1–7) were measured using ELISA kits. Group comparisons were performed using non-parametric statistical tests. Correlation analyses were conducted using Spearman or Pearson coefficients, with significance set at p < 0.05.</div></div><div><h3>Results</h3><div>There were no statistically significant differences in urinary Ang II, Ang-(1–7) or their ratio when comparing PE, GH and controls. However, women with severe PE exhibited significantly higher urinary Ang II levels and Ang II/Ang-(1–7) ratios than those with non-severe PE. In early-onset PE, urinary Ang-(1–7) was positively correlated with creatinine (r = 0.62, p = 0.04) and lactate dehydrogenase levels (r = 0.67, p = 0.02) and the Ang II/Ang-(1–7) ratio correlated strongly with platelet count (r = 0.80, p < 0.001). In late-onset PE, urinary Ang II and its ratio with Ang-(1–7) correlated positively with aspartate aminotransferase (AST) and alanine transaminase, while Ang-(1–7) showed an inverse correlation with AST.</div></div><div><h3>Conclusion</h3><div>Although overall urinary angiotensin levels did not differ, severe PE presented elevated Ang II and Ang II/Ang-(1–7) ratio, suggesting a local shift towards the classical Ang II-mediated pathway in the most severe disease. Furthermore, distinct correlation patterns, such as angiotensins linked to renal and hematologic markers in early-onset PE and to hepatic enzymes in late-onset PE, support different underlying pathophysiological profiles between these subtypes.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"43 ","pages":"Article 101407"},"PeriodicalIF":2.9,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subsequent pregnancy following severe hypertensive disorders of pregnancy 妊娠期严重高血压疾病后的妊娠。

IF 2.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Pub Date : 2025-12-22 DOI: 10.1016/j.preghy.2025.101408

Nimrod Dori-Dayan , Keren Zloto , Rakefet Yoeli-Ullman , Shali Mazaki-Tovi , Abraham Tsur , Sonya Bar-Adon , Keren Ofir , Eyal Sivan , Baha M. Sibai , Michal Fishel Bartal

Background

The impact of the severity of hypertensive disorders of pregnancy (HDP), as defined by current criteria, on future pregnancy outcomes is inadequately described.

Objective

This study evaluated the outcomes of subsequent pregnancies following an initial pregnancy complicated by HDP and assessed the influence of disease severity on the recurrence of HDP (rHDP).

This was a retrospective study. Data were analyzed for individuals with singleton first pregnancy complicated by HDP and a documented subsequent singleton pregnancy. The primary outcome was rHDP.

Results

1035 individuals met inclusion criteria, of whom 981 (95 %) without severe features (SF) while 54 (5 %) had HDP with SF in the first pregnancy. HDP recurred in 32.6 % of subsequent pregnancies. The rate of rHDP and rHDP with SF was higher among those with a prior history of HDP with SF compared to those without SF (61 %vs31% p < 0.01, and 43 %vs5%, p < 0.01, respectively). The incidence of subsequent adverse pregnancy outcomes was higher among individuals with HDP with SF in their first pregnancy compared to those without SF (70 %vs37% p < 0.01). Multivariable regression analysis identified a history of preterm birth (22.3 %vs11.5 %, OR2.24, 95 %CI 1.49, 3.36) and HDP with SF (6.2 %vs4.7 %, OR2.85, 95 %CI 1.6, 5.1) in the first pregnancy as independent risk factors for rHDP.

Conclusion

Four out of ten individuals with a history of HDP experience rHDP in their subsequent pregnancy. A history of severe disease and preterm birth in the first pregnancy is associated with a higher rate of rHDP.

Condensation: A history of severe disease and preterm birth in the first pregnancy is associated with a higher rate of recurrent hypertensive disorders in pregnancy.

背景：妊娠期高血压疾病（HDP）的严重程度，按照目前的标准定义，对未来妊娠结局的影响描述不充分。目的：本研究评估首次妊娠合并HDP后的后续妊娠结局，并评估疾病严重程度对HDP （rHDP）复发的影响。这是一项回顾性研究。对首次妊娠合并HDP的单胎妊娠和随后记录的单胎妊娠的个体进行数据分析。主要终点为rHDP。结果：1035例患者符合纳入标准，其中981例（95%）无严重特征（SF）， 54例（5%）首次妊娠HDP伴SF。HDP在随后妊娠中复发的比例为32.6%。有HDP合并SF病史的孕妇rHDP和rHDP合并SF的发生率高于无SF病史的孕妇（61% vs31%）。结论：10个有HDP病史的孕妇中有4个在随后的妊娠中发生rHDP。有严重疾病史和首次妊娠早产与较高的rHDP发生率相关。凝血：首次妊娠有严重疾病和早产史与妊娠期高血压疾病复发率较高相关。

{"title":"Subsequent pregnancy following severe hypertensive disorders of pregnancy","authors":"Nimrod Dori-Dayan , Keren Zloto , Rakefet Yoeli-Ullman , Shali Mazaki-Tovi , Abraham Tsur , Sonya Bar-Adon , Keren Ofir , Eyal Sivan , Baha M. Sibai , Michal Fishel Bartal","doi":"10.1016/j.preghy.2025.101408","DOIUrl":"10.1016/j.preghy.2025.101408","url":null,"abstract":"<div><h3>Background</h3><div>The impact of the severity of hypertensive disorders of pregnancy (HDP), as defined by current criteria, on future pregnancy outcomes is inadequately described.</div></div><div><h3>Objective</h3><div>This study evaluated the outcomes of subsequent pregnancies following an initial pregnancy complicated by HDP and assessed the influence of disease severity on the recurrence of HDP (rHDP).</div><div>This was a retrospective study. Data were analyzed for individuals with singleton first pregnancy complicated by HDP and a documented subsequent singleton pregnancy. The primary outcome was rHDP.</div></div><div><h3>Results</h3><div>1035 individuals met inclusion criteria, of whom 981 (95 %) without severe features (SF) while 54 (5 %) had HDP with SF in the first pregnancy. HDP recurred in 32.6 % of subsequent pregnancies. The rate of rHDP and rHDP with SF was higher among those with a prior history of HDP with SF compared to those without SF (61 %vs31% p < 0.01, and 43 %vs5%, p < 0.01, respectively). The incidence of subsequent adverse pregnancy outcomes was higher among individuals with HDP with SF in their first pregnancy compared to those without SF (70 %vs37% p < 0.01). Multivariable regression analysis identified a history of preterm birth (22.3 %vs11.5 %, OR2.24, 95 %CI 1.49, 3.36) and HDP with SF (6.2 %vs4.7 %, OR2.85, 95 %CI 1.6, 5.1) in the first pregnancy as independent risk factors for rHDP.</div></div><div><h3>Conclusion</h3><div>Four out of ten individuals with a history of HDP experience rHDP in their subsequent pregnancy. A history of severe disease and preterm birth in the first pregnancy is associated with a higher rate of rHDP.</div><div><strong>Condensation:</strong> A history of severe disease and preterm birth in the first pregnancy is associated with a higher rate of recurrent hypertensive disorders in pregnancy.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"43 ","pages":"Article 101408"},"PeriodicalIF":2.9,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to editor: Hypertensive disorders in a gestational diabetes cohort from Cape Town, South Africa 致编辑的信：来自南非开普敦的妊娠糖尿病队列中的高血压疾病。

IF 2.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Pub Date : 2025-12-15 DOI: 10.1016/j.preghy.2025.101406

Kuldeep Deewan, Aaditya Odhwani, Aman Advani, Kunal Kumar

引用次数: 0

The impact of maternal chronic hypertension in pregnancy on offspring long-term respiratory morbidity 妊娠期母体慢性高血压对子代长期呼吸道疾病的影响

IF 2.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Pub Date : 2025-12-11 DOI: 10.1016/j.preghy.2025.101405

Nir Roguin , Gil Gutvirtz , Tamar Wainstock , Eyal Sheiner

Objective

Maternal chronic hypertension has been associated with various adverse pregnancy and neonatal outcomes, including superimposed preeclampsia and preterm labor, both linked to adverse short- and long-term outcomes. However, most studies investigating offspring long-term outcomes did not isolate chronic hypertension from other hypertensive disorders. Hence, we decided to explore a possible association between maternal chronic hypertension and long-term respiratory morbidity in offspring.

Study design

This population-based cohort included all singleton deliveries from 1991 to 2021 at a tertiary medical center. Offspring of mothers with chronic hypertension were compared to those of normotensive pregnancies. Offspring long-term respiratory morbidity, up to the age of 18 years, was compared using diagnoses from community and hospital records. Kaplan–Meier survival analysis was used to compare the cumulative incidence and a GEE model adjusted for potential confounders.

Results

A total of 342,365 singleton deliveries occurred, of which 3,097 (0.9 %) were to mothers with chronic hypertension. Respiratory morbidity rate of children who were exposed in-utero to maternal chronic hypertension was significantly higher than children from pregnancies that were uncomplicated by hypertensive disorders (p < 0.001). However, cumulative respiratory morbidity was comparable between the groups (Kaplan-Meier Log-rank test p = 0.06). In the GEE model adjusted for maternal age, gestational age, low birthweight, cesarean delivery, fertility treatments, pre-gestational diabetes, smoking, obesity, ethnicity, and child birth year was not independently associated with offspring respiratory morbidity (adjusted HR (aHR) 1.09, 95 % CI 0.74–1.59, p = 0.662)

Conclusion

In our cohort, maternal chronic hypertension is not an independent risk factor for offspring long-term respiratory morbidity.

目的：母体慢性高血压与各种不良妊娠和新生儿结局有关，包括叠加子痫前期和早产，两者都与不良的短期和长期结局有关。然而，大多数调查后代长期预后的研究并没有将慢性高血压与其他高血压疾病分开。因此，我们决定探索母体慢性高血压与后代长期呼吸系统疾病之间的可能联系。研究设计：以人群为基础的队列包括1991年至2021年在三级医疗中心分娩的所有单胎分娩。将慢性高血压母亲的后代与正常妊娠的后代进行比较。根据社区和医院记录的诊断，比较了18岁以下后代的长期呼吸道发病率。Kaplan-Meier生存分析用于比较累积发病率和校正潜在混杂因素的GEE模型。结果共发生单胎分娩342365例，其中慢性高血压产妇3097例（0.9%）。妊娠期暴露于母体慢性高血压的患儿呼吸系统患病率显著高于未合并高血压疾病的妊娠期患儿（p < 0.001）。然而，两组间累积呼吸道发病率具有可比性（Kaplan-Meier Log-rank检验p = 0.06）。在经母亲年龄、胎龄、低出生体重、剖宫产、生育治疗、孕前糖尿病、吸烟、肥胖、种族和出生年份调整后的GEE模型中，与后代呼吸系统疾病无独立相关性（调整后HR (aHR) 1.09, 95% CI 0.74-1.59, p = 0.662）。结论在我们的队列中，母亲慢性高血压不是后代长期呼吸系统疾病的独立危险因素。

{"title":"The impact of maternal chronic hypertension in pregnancy on offspring long-term respiratory morbidity","authors":"Nir Roguin , Gil Gutvirtz , Tamar Wainstock , Eyal Sheiner","doi":"10.1016/j.preghy.2025.101405","DOIUrl":"10.1016/j.preghy.2025.101405","url":null,"abstract":"<div><h3>Objective</h3><div>Maternal chronic hypertension has been associated with various adverse pregnancy and neonatal outcomes, including superimposed preeclampsia and preterm labor, both linked to adverse short- and long-term outcomes. However, most studies investigating offspring long-term outcomes did not isolate chronic hypertension from other hypertensive disorders. Hence, we decided to explore a possible association between maternal chronic hypertension and long-term respiratory morbidity in offspring.</div></div><div><h3>Study design</h3><div>This population-based cohort included all singleton deliveries from 1991 to 2021 at a tertiary medical center. Offspring of mothers with chronic hypertension were compared to those of normotensive pregnancies. Offspring long-term respiratory morbidity, up to the age of 18 years, was compared using diagnoses from community and hospital records. Kaplan–Meier survival analysis was used to compare the cumulative incidence and a GEE model adjusted for potential confounders.</div></div><div><h3>Results</h3><div>A total of 342,365 singleton deliveries occurred, of which 3,097 (0.9 %) were to mothers with chronic hypertension. Respiratory morbidity rate of children who were exposed in-utero to maternal chronic hypertension was significantly higher than children from pregnancies that were uncomplicated by hypertensive disorders (p < 0.001). However, cumulative respiratory morbidity was comparable between the groups (Kaplan-Meier Log-rank test <em>p</em> = 0.06). In the GEE model adjusted for maternal age, gestational age, low birthweight, cesarean delivery, fertility treatments, pre-gestational diabetes, smoking, obesity, ethnicity, and child birth year was not independently associated with offspring respiratory morbidity (adjusted HR (aHR) 1.09, 95 % CI 0.74–1.59, p = 0.662)</div></div><div><h3>Conclusion</h3><div>In our cohort, maternal chronic hypertension is not an independent risk factor for offspring long-term respiratory morbidity.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"43 ","pages":"Article 101405"},"PeriodicalIF":2.9,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145738123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0