Focus on the Forgotten Organelle: Regulation of Lysosomes in Skeletal Muscle.

IF 4.9 2区 医学 Q1 PHYSIOLOGY Exercise and Sport Sciences Reviews Pub Date : 2025-01-13 DOI:10.1249/JES.0000000000000358
Neushaw Moradi, Anastasiya Kuznyetsova, Victoria C Sanfrancesco, Sabrina Champsi, David A Hood
{"title":"Focus on the Forgotten Organelle: Regulation of Lysosomes in Skeletal Muscle.","authors":"Neushaw Moradi, Anastasiya Kuznyetsova, Victoria C Sanfrancesco, Sabrina Champsi, David A Hood","doi":"10.1249/JES.0000000000000358","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>Research on the role of the lysosome as the terminal organelle in autophagy and in communicating with other organelles in skeletal muscle is in its infancy. We hypothesize that the lysosome can adapt positively to exercise to improve the clearance of cargo, like dysfunctional mitochondria, within muscle, representing an important therapy for protein homeostasis in aging and muscle disuse.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exercise and Sport Sciences Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1249/JES.0000000000000358","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Abstract: Research on the role of the lysosome as the terminal organelle in autophagy and in communicating with other organelles in skeletal muscle is in its infancy. We hypothesize that the lysosome can adapt positively to exercise to improve the clearance of cargo, like dysfunctional mitochondria, within muscle, representing an important therapy for protein homeostasis in aging and muscle disuse.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
关注被遗忘的细胞器:骨骼肌溶酶体的调节。
摘要:骨骼肌中溶酶体作为终端细胞器在自噬和与其他细胞器通讯中的作用研究尚处于起步阶段。我们假设溶酶体可以积极适应运动,以改善肌肉内功能失调线粒体等货物的清除,代表了衰老和肌肉废用中蛋白质稳态的重要治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Exercise and Sport Sciences Reviews
Exercise and Sport Sciences Reviews 社会科学-生理学
CiteScore
10.70
自引率
1.80%
发文量
72
期刊介绍: Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.
期刊最新文献
Exercise May Improve Completion of Standard and Emerging Cancer Treatments. Personalized Injury Risk Assessment and Exercise Prescription Based on Tendon Strain. Focus on the Forgotten Organelle: Regulation of Lysosomes in Skeletal Muscle. Modulation of Vascular Health by Hormonal Contraceptives and Exercise in Young Women: Using the FITT Principles Methodological Framework. Task-Dependent Mechanisms Underlying Prolonged Low-Frequency Force Depression.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1