Alterations in resting-state EEG functional connectivity in patients with major depressive disorder receiving electroconvulsive therapy: A systematic review

Abstract

Electroconvulsive therapy (ECT) is highly efficacious for the treatment of major depressive disorder (MDD), but its mechanisms still require clarification. Even though depression is associated with alterations in functional connectivity (FC), EEG studies investigating effects of ECT on FC have not been systematically reviewed. Understanding these effects may help to identify the role of functional brain circuits in depression and its remission. This systematic review aimed to synthesize EEG studies investigating FC changes in ECT-treated patients with depression. A systematic literature search was conducted following PRISMA guidelines. Peer-reviewed studies on pre-to post-ECT resting-state EEG FC changes in adult patients with MDD were included. Three of 143 studies were included, of which two reported reduced FC in the alpha and beta frequency bands and increased theta band FC in patients with ECT-treated MDD. Changes in alpha band FC were associated with treatment outcomes. Patients with MDD exhibit increased electrophysiological resting-state alpha band FC, particularly frontally, compared with healthy subjects. Thus, ECT-induced decrease might indicate a trend toward normalization of oscillatory brain rhythms. As brain oscillations have been proposed to be involved in neuronal synchronization, which is important for communication between networks, the potential restoration in patients with depression and the association of FC changes with clinical improvement may indicate a potential mechanism of action of ECT. Understanding ECT’s underlying mechanisms might ultimately enable treatment optimization, thus enhancing patient care. However, the number of studies is limited, with low-to-moderate EEG study quality, small sample sizes, and different electrophysiological FC measures.