Neurophysiological Markers of Regulation Success in Everyday Life in Depression

Abstract

Background

Self-regulation is often disrupted in depression and is characterized by negative affect and inflexible parasympathetic responses. However, our understanding of brain mechanisms of self-regulatory processes has largely been limited to laboratory contexts. Measuring individual differences in self-regulatory processes in everyday life—and their neural correlates—could inform our understanding of depression phenotypes and reveal novel intervention targets that impact everyday functioning.

Methods

In individuals with remitted major depressive disorder and healthy comparison participants (N = 74), we measured 2 dimensions of regulation success in everyday life—perceived success with regulating affect and physiological success (parasympathetic augmentation following regulation attempts)—and their neural correlates using a functional magnetic resonance imaging emotion regulation task.

Results

Perceptions of success were weakly associated with physiological success and had partially distinct neural correlates. Perceived success and physiological success in everyday life predicted reduced activity in brain regions involved in emotional salience while reacting to aversive stimuli in the scanner. During reappraisal in the scanner, greater perceived success in everyday life was dimensionally associated with more reappraisal-related activity in regions involved in cognitive control (including the dorsolateral and dorsomedial prefrontal cortices); in contrast, physiological success predicted enhanced downregulation of salience network activity (amygdala, insula).

Conclusions

Results suggest that linking psychophysiology with behavior in everyday life can provide a window into dissociable dimensions of self-regulatory functioning. Integrating ambulatory and brain-based metrics may elucidate self-regulatory phenotypes with distinct neurophysiological mechanisms and targets for intervention to impact functioning in daily life.