Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Grief-Specific or Domain-General? Integrative Neuroimaging Perspectives for Understanding Long-Term Grief","authors":"Saren H. Seeley","doi":"10.1016/j.bpsc.2025.10.008","DOIUrl":"10.1016/j.bpsc.2025.10.008","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1215-1217"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory and Visual Thalamocortical Connectivity Alterations in Unmedicated People With Schizophrenia: An Individualized Sensory Thalamic Localization and Resting-State Functional Connectivity Study","authors":"John C. Williams ,&nbsp;Philip N. Tubiolo ,&nbsp;Roberto B. Gil ,&nbsp;Zu Jie Zheng ,&nbsp;Eilon B. Silver-Frankel ,&nbsp;Natalka K. Haubold ,&nbsp;Sameera K. Abeykoon ,&nbsp;Dathy T. Pham ,&nbsp;Najate Ojeil ,&nbsp;Kelly Bobchin ,&nbsp;Mark Slifstein ,&nbsp;Jodi J. Weinstein ,&nbsp;Greg Perlman ,&nbsp;Guillermo Horga ,&nbsp;Anissa Abi-Dargham ,&nbsp;Jared X. Van Snellenberg","doi":"10.1016/j.bpsc.2025.05.016","DOIUrl":"10.1016/j.bpsc.2025.05.016","url":null,"abstract":"<div><h3>Background</h3><div>Converging evidence from clinical neuroimaging and animal models has strongly implicated dysfunction of thalamocortical circuits in the pathophysiology of schizophrenia (SZ). Preclinical models of genetic risk for SZ have shown reduced synaptic transmission from the auditory thalamus to the primary auditory cortex, which may represent a correlate of auditory disturbances such as hallucinations. However, human neuroimaging studies have found a generalized increase in resting-state functional connectivity (RSFC) between whole thalamus and sensorimotor cortex in people with SZ (PSZ). We aimed to more directly translate preclinical findings by specifically localizing auditory and visual thalamic nuclei in unmedicated PSZ and measuring RSFC to primary sensory cortices.</div></div><div><h3>Methods</h3><div>In this case-control study, 82 unmedicated PSZ and 55 matched healthy control participants (HCs) completed RSFC functional magnetic resonance imaging (fMRI) (<em>N</em> = 137). Auditory and visual thalamic nuclei were localized for 55 unmedicated PSZ and 46 HCs who also completed a sensory thalamic nuclei localizer fMRI task (<em>n</em> = 101). Using localized nuclei as RSFC seeds, we assessed group differences in auditory and visual thalamocortical connectivity and associations with positive symptom severity.</div></div><div><h3>Results</h3><div>Auditory thalamocortical connectivity was not significantly different between PSZ and HCs, but hyperconnectivity was associated with greater positive symptom severity in the bilateral superior temporal gyrus. Visual thalamocortical connectivity was significantly greater in PSZ relative to HCs in the secondary and higher-order visual cortex but was not predictive of positive symptom severity.</div></div><div><h3>Conclusions</h3><div>These results indicate that visual thalamocortical hyperconnectivity is a generalized marker of SZ, while hyperconnectivity in auditory thalamocortical circuits relates more specifically to positive symptom severity.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1239-1248"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(25)00343-X","DOIUrl":"10.1016/S2451-9022(25)00343-X","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages A5-A10"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Sensitivity of the Mini-Mental State Examination to Detect Objective Cognitive Side Effects Induced by Electroconvulsive Therapy: Results From the Dutch ECT Consortium","authors":"Dore Loef ,&nbsp;Philip F.P. van Eijndhoven ,&nbsp;Sigfried N.T.M. Schouws ,&nbsp;Arjen J.C. Slooter ,&nbsp;Nikki Janssen ,&nbsp;Rob M. Kok ,&nbsp;Bart P.F. Rutten ,&nbsp;Eric van Exel ,&nbsp;Didi Rhebergen ,&nbsp;Mardien L. Oudega ,&nbsp;Roel J.T. Mocking ,&nbsp;Indira Tendolkar ,&nbsp;Annemiek Dols ,&nbsp;Esmée Verwijk","doi":"10.1016/j.bpsc.2024.08.002","DOIUrl":"10.1016/j.bpsc.2024.08.002","url":null,"abstract":"<div><h3>Background</h3><div>Monitoring cognitive side effects following electroconvulsive therapy (ECT) is crucial for balancing side effects and clinical effectiveness. Yet, evidence-based guidelines on cognitive testing following ECT are lacking. A frequently used test in global ECT practice is the Mini-Mental State Examination (MMSE). We examined the change of the MMSE score and its performance in identifying a decline in predefined neuropsychological measures sensitive to ECT-induced cognitive changes: verbal recall and verbal fluency.</div></div><div><h3>Methods</h3><div>Mean MMSE scores before and 1 week after ECT were compared using a Wilcoxon signed rank test. The Reliable Change Index was calculated for all cognitive measures to indicate whether a participant’s change in score from pre- to post-ECT was considered statistically significant. The sensitivity and specificity of the MMSE were calculated.</div></div><div><h3>Results</h3><div>A total of 426 patients with depression from 5 sites were included from the Dutch ECT Consortium. Mean (SD) MMSE score increased significantly from 26.2 (3.9) before ECT to 26.8 (3.8) after ECT (<em>p</em> = .002). After ECT, 36 patients (8.5%) showed a significant decline in MMSE score. The sensitivity of the MMSE in identifying patients who experienced a significant decline in verbal recall or verbal fluency ranged from 3.6% to 11.1%. The specificity of the MMSE in identifying patients who did not experience a significant decline in verbal recall or verbal fluency ranged from 95.6% to 96.6%.</div></div><div><h3>Conclusions</h3><div>Given the very low sensitivity of the MMSE, we propose reconsidering the prominence of the MMSE in ECT practice and cognitive monitoring guidelines, advocating for a more comprehensive approach to assess ECT-induced cognitive changes.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1268-1275"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obsessive-Compulsive Disorder Comorbid With or Without Obsessive-Compulsive Personality Disorder: Conceptual Implications, Clinical Correlates, and Brain Morphometries","authors":"Chen Zhang ,&nbsp;Zongfeng Zhang ,&nbsp;Rui Gao ,&nbsp;Yongjun Chen ,&nbsp;Xuan Cao ,&nbsp;Xianghan Yi ,&nbsp;Qing Fan","doi":"10.1016/j.bpsc.2024.09.010","DOIUrl":"10.1016/j.bpsc.2024.09.010","url":null,"abstract":"<div><h3>Background</h3><div>Obsessive-compulsive disorder (OCD) is often comorbid with obsessive-compulsive personality disorder (OCPD). The relationship between OCD and OCPD is complex, and the impact of comorbid OCPD on OCD remains underexplored, necessitating further research. In this study, we aimed to investigate the clinical correlates and brain morphometries associated with comorbid OCPD in a large sample of unmedicated patients with OCD.</div></div><div><h3>Methods</h3><div><span>A total of 248 unmedicated patients diagnosed with OCD (45 comorbid with OCPD) were included in this study. All participants were assessed for OCD symptoms, OCPD traits, obsessive beliefs, depression, and anxiety. Among them, 145 patients (23 comorbid with OCPD) volunteered to receive magnetic resonance imaging </span>brain scans.</div></div><div><h3>Results</h3><div><span>Approximately 18% (45/248) of patients with OCD were comorbid for OCPD (OCD+OCPD). Patients with OCD+OCPD exhibited more severe OCD symptoms, obsessive beliefs, depression, and anxiety than OCD patients without OCPD. Additionally, the severity of OCPD was positively correlated with OCD symptoms and obsessive beliefs. Furthermore, patients with OCD+OCPD exhibited increased cortical complexity in the left </span>superior parietal lobule<span> and left precuneus, which mediated the relationship between OCPD and OCD symptoms only in OCD patients without OCPD.</span></div></div><div><h3>Conclusions</h3><div>The co-occurrence of OCPD may contribute to the heightened severity of psychopathological symptoms and associated brain morphological alterations in patients with OCD, indicating distinct but interrelated constructs between these 2 disorders.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1276-1283"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging and Glutamatergic Trials in Psychosis: Where Are We Standing, and Where Do We Go Now?","authors":"Camilo de la Fuente-Sandoval","doi":"10.1016/j.bpsc.2025.10.003","DOIUrl":"10.1016/j.bpsc.2025.10.003","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1213-1214"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated Aging of White Matter in Late-Life Depression: Evidence From 18F-Flutemetamol Positron Emission Tomography Imaging","authors":"Akihiro Takamiya ,&nbsp;Thomas Vande Casteele ,&nbsp;Filip Bouckaert ,&nbsp;Margot G.A. Van Cauwenberge ,&nbsp;Maarten Laroy ,&nbsp;François-Laurent De Winter ,&nbsp;Patrick Dupont ,&nbsp;Jan Van den Stock ,&nbsp;Michel Koole ,&nbsp;Koen Van Laere ,&nbsp;Louise Emsell ,&nbsp;Mathieu Vandenbulcke","doi":"10.1016/j.bpsc.2025.03.013","DOIUrl":"10.1016/j.bpsc.2025.03.013","url":null,"abstract":"<div><h3>Background</h3><div><span>Late-life depression (LLD) is associated with white matter (WM) alterations. Current evidence indicates that amyloid positron emission tomography (PET) </span>tracers are sensitive and reliable markers for evaluating normal-appearing WM (NAWM) on magnetic resonance imaging (MRI), showing an association between lower uptake and Alzheimer’s disease pathology and higher uptake with age-related changes. Utilizing this novel and reliable technique, we aimed to distinguish between 2 hypothetical models for neurobiology of LLD, the pathological neurodegenerative model and the accelerated aging model.</div></div><div><h3>Methods</h3><div>In this monocentric cross-sectional study, a total of 103 participants, including 61 patients with LLD (age 73.8 ± 7.0 years; 41 female) and 42 healthy control (HC) participants (age 72.5 ± 7.6 years; 28 female), underwent PET imaging with ¹⁸F-flutemetamol, MRI, and clinical assessment. T2-weighted fluid-attenuated inversion recovery images were segmented into WM hyperintensities (WMHs) and NAWM.</div></div><div><h3>Results</h3><div>The ¹⁸<span>F-flutemetamol standardized uptake value ratio (SUVR) in WMHs was significantly lower than that in NAWM (</span><em>t</em>₁₀₂ = 7.8, <em>p</em> &lt; .001). Compared with HC participants, patients with LLD exhibited higher ¹⁸F-flutemetamol SUVR in both NAWM (<em>p</em> &lt; .001, Cohen’s <em>d</em> = 0.91) and WMHs (<em>p</em> = .005, <em>d</em> = 0.56), even after controlling for age and ¹⁸F-flutemetamol SUVR in cortical gray matter.</div></div><div><h3>Conclusions</h3><div>Our result of elevated ¹⁸<span>F-flutemetamol uptake in NAWM is not consistent with the pathological neurodegenerative aging pattern observed in Alzheimer’s disease but is consistent with patterns of age-related changes. This distinction is crucial for the development of future targeted treatments.</span></div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1294-1301"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Maternal and Paternal Parenting on Adolescent Brain Structure","authors":"Qingwen Ding ,&nbsp;Xinying Li ,&nbsp;Divyangana Rakesh ,&nbsp;Siya Peng ,&nbsp;Jiahua Xu ,&nbsp;Jie Chen ,&nbsp;Nengzhi Jiang ,&nbsp;Yu Luo ,&nbsp;Xuebing Li ,&nbsp;Shaozheng Qin ,&nbsp;Sarah Whittle","doi":"10.1016/j.bpsc.2024.06.013","DOIUrl":"10.1016/j.bpsc.2024.06.013","url":null,"abstract":"<div><h3>Background</h3><div><span>Adolescents raised in families with different maternal and paternal parenting combinations exhibit variations in neurocognition and psychopathology; however, whether neural differences exist remains unexplored. This study used a longitudinal twin sample to delineate how different parenting combinations influence adolescent brain structure and to elucidate the </span>genetic contribution.</div></div><div><h3>Methods</h3><div>A cohort of 216 twins participated in parenting assessments during early adolescence and underwent magnetic resonance imaging scanning during middle adolescence. We utilized latent profile analysis<span><span> to distinguish between various maternal and paternal parenting profiles and subsequently investigated their influences on brain anatomy. </span>Biometric analysis was applied to assess genetic influences on brain structure, and associations with internalizing symptoms were explored.</span></div></div><div><h3>Results</h3><div><span>In early adolescence, 4 parenting profiles emerged, which were characterized by levels of harshness and hostility in one or both parents. Compared with adolescents in “catparent” families (low harshness/hostility in both parents), those raised in “tigermom” families (harsh/hostile mother only) exhibited a smaller nucleus accumbens<span> volume and larger temporal cortex<span> surface area; those in “tigerdad” families demonstrated larger </span></span></span>thalamus<span> volumes; and those in “tigerparent” families displayed smaller volumes in the midanterior corpus callosum<span>. Genetic risk factors contributed significantly to the observed brain structural heterogeneity and internalizing symptoms. However, the influences of parenting profiles and brain structure on internalizing symptoms were not significant.</span></span></div></div><div><h3>Conclusions</h3><div>The findings underscore distinct brain structural features linked to maternal and paternal parenting combinations, particularly in terms of subcortical volume and cortical surface area. This study suggests an interdependent role of maternal and paternal parenting in shaping adolescent neurodevelopment.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1249-1257"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamatergic Modulation of Brain Function in Psychosis: A Systematic Review of Neuroimaging Studies","authors":"Ioana Varvari ,&nbsp;Lara Bolte ,&nbsp;Chiara Colli ,&nbsp;Valentina Mancini ,&nbsp;Matthew M. Nour ,&nbsp;Philip McGuire ,&nbsp;Robert A. McCutcheon","doi":"10.1016/j.bpsc.2025.07.004","DOIUrl":"10.1016/j.bpsc.2025.07.004","url":null,"abstract":"<div><div>Aberrant dopamine and glutamate signaling are implicated in the pathophysiology of schizophrenia. Existing treatments primarily target dopamine pathways underlying positive symptoms but have relatively little effect on cognitive and negative symptoms. Glutamatergic modulators may treat the latter symptom domains, and neuroimaging studies have the potential to identify therapeutic mechanisms. We conducted a systematic review to examine functional neuroimaging studies of glutamatergic modulators in psychosis and determine whether these agents alter brain activity, chemistry, or functional connectivity and whether such changes map onto clinical outcomes. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (PROSPERO: <span><span>CRD42024549120</span><svg><path></path></svg></span>), MEDLINE, Embase, and PsycInfo were searched from inception to June 2024 for studies administering pharmacologic glutamate modulators to individuals with psychosis, using functional neuroimaging (proton magnetic resonance spectroscopy [¹H-MRS], functional magnetic resonance imaging [fMRI], arterial spin labeling, positron emission tomography, electroencephalography [EEG], or magnetoencephalography). Twenty-seven articles met inclusion criteria, encompassing 841 participants. Evidence from ¹H-MRS suggests that sarcosine, <em>N</em>-acetylcysteine, and riluzole reduce glutamate concentrations in frontal and hippocampal regions, but clinical outcomes have not been investigated. Resting-state and task-based fMRI studies suggest that NMDA receptor modulators may normalize measures of functional dysconnectivity, although effects were often short-lived and did not always correspond to sustained symptom improvements. Similarly, EEG studies consistently identified normalization of mismatch negativity and gamma oscillations, but correlations with symptom or cognitive outcomes were inconsistent. While glutamatergic modulators show measurable effects on brain chemistry and electrophysiology, the relationship to robust, durable clinical benefits remains elusive. Future work should use larger, longer-duration, and multimodal imaging studies to clarify the precise mechanisms, optimal dosing, and the patient subgroups most likely to benefit from glutamatergic interventions in psychosis.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1221-1238"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers' Page","authors":"","doi":"10.1016/S2451-9022(25)00340-4","DOIUrl":"10.1016/S2451-9022(25)00340-4","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Page A2"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}