Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

Resolving Uncertainties in a Social World 解决社会世界中的不确定性

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.09.005

Joseph M. Barnby

引用次数: 0

Neurophysiological Pathways of Unconscious Emotion Processing in Depression: Insights From a Simultaneous Electroencephalography–Functional Magnetic Resonance Imaging Measurement 抑郁症患者无意识情绪处理的神经生理学途径：脑电图-核磁共振成像同步测量的启示。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.07.005

Julia Schräder , Lennard Herzberg , Han-Gue Jo , Lucia Hernandez-Pena , Julia Koch , Ute Habel , Lisa Wagels

Background

Major depressive disorder (MDD) is characterized by strong emotional dysregulation. Mechanisms driving the negative affect in depression may be fast processes existing on an unconscious level.

Methods

A priming task was conducted using simultaneous electroencephalography–functional magnetic resonance imaging measurement involving presentation of facial expressions (happy, sad, and neutral) to examine the neurophysiological pathway of biased unconscious emotion processing in MDD. Priming prior to a target emotion created unconscious (16.7-ms primer) and conscious (150-ms primer) trials. A large sample (N = 126) was recruited, containing healthy control participants (n = 66; 37 women) and participants with MDD (n = 60; 31 women).

Results

The healthy control group showed a shorter reaction time in happy but not in sad or neutral trials compared with the MDD group. N170 amplitudes were lower in trials with unconscious than conscious primer presentation. N170 amplitudes correlated with cortical (right fusiform gyrus, right middle temporal gyrus, right inferior temporal gyrus, left supplementary motor area, right middle frontal gyrus) and subcortical brain regions (right amygdala). The strength of N170 and brain activity correlation increased when the stimulus was consciously presented. Presented emotions did not affect the correlation of N170 values and brain activity.

Conclusions

Our findings show that MDD may exhibit biased emotion regulation abilities at a behavioral and neurophysiological level. Face-sensitive event-related potentials demonstrate a correlation with heightened brain activity in regions associated with both face recognition (fusiform gyrus) and emotion processing (amygdala). These findings are evident in both MDD and healthy control groups, with lower effect sizes in the MDD group indicating reduced emotion recognition and processing abilities.

背景：重度抑郁障碍（MDD）的特点是强烈的情绪失调。驱动抑郁症负面情绪的机制可能是存在于无意识层面的快速过程：方法：通过同时测量脑电图-核磁共振成像（EEG-FMRI）和面部表情（快乐、悲伤、中性）来进行引物任务，以研究 MDD 中偏向无意识情绪处理的神经生理学途径。在目标情绪之前的引物会产生无意识（16.7 毫秒引物）和有意识（150 毫秒引物）试验。研究人员招募了一个 N = 126 的大样本，其中包括健康对照组（HC；n = 66；37 名女性）和 MDD（n = 60；31 名女性）：结果：与 MDD 相比，HC 在快乐试验中的反应时间较短，但在悲伤或中性试验中的反应时间较短。在无意识引物呈现的试验中，N170振幅低于有意识引物呈现的试验。N170振幅与皮层（右侧纺锤形回（FFG）、右侧颞中回、右侧颞下回、左侧辅助运动区、右侧额中回）和皮层下脑区（右侧杏仁核）相关。当有意识地呈现刺激时，N170 和大脑活动相关性的强度会增加。呈现的情绪并不影响N170值与大脑活动的相关性：我们的研究结果表明，MDD可能在行为和神经生理学水平上表现出有偏差的情绪调节能力。对人脸敏感的事件相关电位显示，与人脸识别（FFG）和情绪处理（杏仁核）相关区域的大脑活动增强具有相关性。这些发现在 MDD 和 HC 中都很明显，MDD 的效应大小较低，表明情绪识别和处理能力下降。

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引用次数: 0

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IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/S2451-9022(24)00287-8

引用次数: 0

Cognitive Profiles in Treatment-Resistant Late-Life Depression and Their Impact on Treatment Outcomes 难治性晚期抑郁症患者的认知特征及其对治疗结果的影响》（Cognitive Profiles in Treatment-Ristant Late-Life Depression and their Impact on Treatment Outcomes.

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.07.009

Katharina Göke , Shawn M. McClintock , Linda Mah , Tarek K. Rajji , Hyewon H. Lee , Sean M. Nestor , Jonathan Downar , Yoshihiro Noda , Zafiris J. Daskalakis , Benoit H. Mulsant , Daniel M. Blumberger

Background

Late-life depression (LLD) is associated with cognitive impairment, but substantial heterogeneity exists among patients. Data on the extent of cognitive impairments are inconclusive, particularly in patients with treatment-resistant depression (TRD). We investigated the cognitive profiles of patients with treatment-resistant versus nonresistant LLD and aimed to identify distinct cognitive subgroups. We also examined whether cognitive subgroups responded differentially to treatment with bilateral repetitive transcranial magnetic stimulation (rTMS).

Methods

A total of 165 patients with LLD were divided into treatment-resistant and nonresistant groups and compared with healthy control participants on measures of executive function, information processing speed, verbal learning, and memory. Cluster analysis identified subgroups based on cognitive scores. Demographic and clinical variables, as well as outcomes with bilateral rTMS, were compared between cognitive subgroups.

Results

Patients with LLD, particularly TRD, exhibited significantly worse cognitive performance than healthy controls. A 3-cluster solution was found, including cognitively intact (n = 89), cognitively diminished (n = 29), and impaired memory (n = 47) subgroups. Both the cognitively diminished and impaired memory subgroups had more anxiety symptoms and a higher proportion of patients with TRD than the cognitively intact group, although the latter difference did not survive multiple comparison correction. No significant differences were observed in outcomes to rTMS treatment.

Conclusions

Patients with LLD exhibited impairments across cognitive domains, which were more pronounced in TRD. Three cognitive subgroups responded similarly to rTMS treatment, indicating its effectiveness across cognitive profiles, especially when medications are not tolerated. Future research should examine the relationships among cognitive subgroups, cognitive decline, and neurodegeneration.

背景：晚期抑郁症（LLD）与认知障碍有关，但患者之间存在很大的异质性。有关认知障碍程度的数据尚无定论，尤其是在耐药性抑郁症（TRD）患者中。我们研究了耐药性 LLD 患者与非耐药性 LLD 患者的认知概况，旨在确定不同的认知亚群。此外，我们还研究了认知亚组是否对双侧重复经颅磁刺激（rTMS）治疗有不同的反应。方法：165 名 LLD 患者被分为治疗耐受组和非耐受组，并与健康对照组（HC）在执行功能、信息处理速度、言语学习和记忆方面进行了比较。聚类分析根据认知评分确定了亚组。对认知亚组之间的人口统计学和临床变量以及双侧经颅磁刺激的结果进行了比较：结果：LLD患者，尤其是TRD患者的认知表现明显差于HC患者。研究发现了一种三群组解决方案，包括 "认知完整"（89 人）、"认知减退"（29 人）和 "记忆受损"（47 人）亚群组。与 "认知功能完整 "组相比，"认知功能减退 "和 "记忆力受损 "亚组的焦虑症状更多，TRD患者的比例更高，但后者未能通过多重比较校正。经颅磁刺激治疗的结果无明显差异：结论：LLD患者在各个认知领域都存在障碍，这在TRD患者中更为明显。三个已确定的认知亚组对经颅磁刺激治疗的反应相似，这表明经颅磁刺激治疗对各种认知状况都有效，尤其是在不能耐受药物治疗的情况下。未来的研究应探讨认知亚组、认知功能衰退和神经变性之间的关系。

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引用次数: 0

Eigenvector Centrality Mapping Reveals Volatility of Functional Brain Dynamics in Anti-NMDA Receptor Encephalitis 特征向量中心性图谱揭示了抗NMDA受体脑炎中大脑功能动态的波动性。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.07.021

Tim J. Hartung , Nina von Schwanenflug , Stephan Krohn , Tommy A.A. Broeders , Harald Prüss , Menno M. Schoonheim , Carsten Finke

Background

Anti-NMDA receptor encephalitis (NMDARE) causes long-lasting cognitive deficits associated with altered functional connectivity. Eigenvector centrality (EC) mapping represents a powerful new method for data-driven voxelwise and time-resolved estimation of network importance—beyond changes in classical static functional connectivity.

Methods

To assess changes in functional brain network organization, we applied EC mapping in 73 patients with NMDARE and 73 matched healthy control participants. Areas with significant group differences were further investigated using 1) spatial clustering analyses, 2) time series correlation to assess synchronicity between the hippocampus and cortical brain regions, and 3) correlation with cognitive and clinical parameters.

Results

Dynamic, time-resolved EC showed significantly higher variability in 13 cortical areas (familywise error p < .05) in patients with NMDARE compared with healthy control participants. Areas with dynamic EC group differences were spatially organized in centrality clusters resembling resting-state networks. Importantly, variability of dynamic EC in the frontotemporal cluster was associated with impaired verbal episodic memory in patients (r = −0.25, p = .037). EC synchronicity between the hippocampus and the medial prefrontal cortex was reduced in patients compared with healthy control participants (familywise error p < .05, t_max = 3.76) and associated with verbal episodic memory in patients (r = 0.28, p = .019). Static EC analyses showed group differences in only one brain region (left intracalcarine cortex).

Conclusions

Widespread changes in network dynamics and reduced hippocampal-medial prefrontal synchronicity were associated with verbal episodic memory deficits and may thus represent a functional neural correlate of cognitive dysfunction in NMDARE. Importantly, dynamic EC detected substantially more network alterations than traditional static approaches, highlighting the potential of this method to explain long-term deficits in NMDARE.

背景：抗N-甲基-D-天冬氨酸受体脑炎（NMDARE）会导致与功能连接性改变相关的长期认知障碍。特征向量中心性（EC）绘图是一种功能强大的新方法，可通过数据驱动的体素和时间分辨来估计网络的重要性--超越了经典的 "静态 "功能连通性的变化：为了评估大脑功能网络组织的变化，我们对 73 名 NMDARE 患者和 73 名匹配的健康对照者进行了 EC 映射。结果：动态、时间分辨 EC 显示，海马区和皮质脑区之间的同步性与认知和临床参数相关：动态、时间分辨EC在13个皮质区域显示出明显较高的变异性（p(FWE)(FWE)(max)=3.76），并与患者的言语外显记忆相关（r=0.28，p=0.019）。静态EC分析显示，只有一个脑区（左侧钙内皮层）存在群体差异：网络动态的广泛变化和海马-内侧前额叶同步性的降低与言语表观记忆缺陷有关，因此可能代表了 NMDARE 认知功能障碍的功能神经相关性。重要的是，与传统的静态方法相比，动态EC检测到的网络改变要多得多，这凸显了这种方法在解释NMDARE长期缺陷方面的潜力。

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引用次数: 0

Impairment of Visual Fixation and Preparatory Saccade Control in Borderline Personality Disorder With and Without Comorbid Attention-Deficit/Hyperactivity Disorder 伴有或不伴有注意力缺陷/多动障碍的边缘型人格障碍患者的视线固定和准备性跳跃控制能力受损。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.07.003

Olivia G. Calancie , Ashley C. Parr , Don C. Brien , Brian C. Coe , Linda Booij , Sarosh Khalid-Khan , Doug P. Munoz

Background

Borderline personality disorder (BPD) is associated with heightened impulsivity, evidenced by increased substance abuse, self-harm, and suicide attempts. Addressing impulsivity in individuals with BPD is a therapeutic objective, but its underlying neural basis in this clinical population remains unclear, partly due to its frequent comorbidity with attention-deficit/hyperactivity disorder (ADHD).

Methods

We used a response inhibition paradigm—the interleaved pro-/antisaccade task—among adolescents diagnosed with BPD with and without comorbid ADHD (n = 25 and n = 24, respectively) during concomitant video-based eye tracking. We quantified various eye movement response parameters reflective of impulsive action during the task, including delay to fixation acquisition, fixation breaks, anticipatory saccades, and direction errors with express saccade (saccade reaction time: 90–140 ms) and regular saccade latencies (saccade reaction time > 140 ms).

Results

Individuals with BPD exhibited deficient response preparation, as evidenced by reduced visual fixation on task cues and greater variability of saccade responses (i.e., saccade reaction time and peak velocity). The ADHD/BPD group shared these traits and made more anticipatory responses and direction errors with express saccade latencies and reduced error correction.

Conclusions

Saccadic deficits in BPD and ADHD/BPD stemmed not from an inability to execute antisaccades but rather from inadequate preparation for the upcoming task set. These distinctions may arise due to abnormal signaling in cortical areas like the frontal eye fields, posterior parietal cortex, and anterior cingulate cortex. Understanding these mechanisms could provide insights into targeted interventions focusing on task set preparation to manage response inhibition deficits in BPD and ADHD/BPD.

背景：边缘型人格障碍（BPD）与冲动性增强有关，表现为药物滥用、自残和自杀企图增多。解决 BPD 患者的冲动问题是一项治疗目标；但在这一临床人群中，其潜在的神经基础仍不清楚，部分原因是它经常与注意力缺陷/多动障碍（ADHD）共病：我们采用了一种反应抑制范式--交错前/反回旋任务（IPAST）--在同时进行视频眼动追踪的过程中，对被诊断为伴有或不伴有多动症的青少年（分别为 25 人和 24 人）进行了研究。我们对任务中反映冲动性动作的各种眼动反应参数进行了量化，包括获得定点的延迟、定点中断、预期性囊回以及快速囊回的方向错误（囊回反应时间 [SRT]：90-140 毫秒）和常规囊回延迟（SRT > 140 毫秒）：结果：患有 BPD 的个体表现出反应准备不足，具体表现为对任务线索的视觉固定减少，以及囊回反应（即 SRT 和峰值速度）的变异性更大。ADHD/BPD组也具有这些特征，同时还表现出更高频率的预期反应和方向错误，囊回延迟更快，错误纠正更少：结论：BPD和ADHD/BPD的回闪缺陷并非源于无法执行反回闪，而是源于对即将到来的任务准备不足。这些区别可能是由于额叶眼区、后顶叶皮层和前扣带回皮层等皮层区域的信号异常造成的。了解这些机制可以为有针对性的干预措施提供启示，这些干预措施侧重于任务集准备，以控制BPD和ADHD/BPD的反应抑制缺陷。

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引用次数: 0

Peak Alpha Frequency in Schizophrenia, Bipolar Disorder, and Healthy Volunteers: Associations With Visual Information Processing and Cognition 精神分裂症、双相情感障碍和健康志愿者的α峰频率：与视觉信息处理和认知的关联。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.06.004

Background

Schizophrenia (SCZ) and bipolar disorder (BD) are associated with information processing abnormalities, including visual perceptual and cognitive impairments, that impact daily functioning. Recent work with healthy samples suggests that peak alpha frequency (PAF) is an electrophysiological index of visual information processing speed that is correlated with cognitive ability. There is evidence that PAF is slowed in SCZ, but it remains unclear whether PAF is reduced in BD or whether slower PAF is associated with impaired visual perception and cognition in these clinical disorders.

Methods

We recorded resting-state brain activity (both eyes open and closed) with electroencephalography in 90 participants with SCZ, 62 participants with BD, and 69 healthy control participants. Most participants also performed a visual perception task (backward masking) and cognitive testing (MATRICS Concensus Cognitive Battery).

Results

We replicated previous findings of reduced PAF in patients with SCZ compared with healthy control participants. In contrast, PAF in patients with BD did not differ significantly from that in healthy control participants. Furthermore, PAF was significantly correlated with performance on the perceptual and cognitive measures in SCZ but not BD. PAF was also correlated with visual perception in the healthy control group and showed a trend-level correlation with cognition.

Conclusions

Together, these results suggest that PAF deficits characterize SCZ, but not BD, and that individual differences in PAF are related to abnormalities in visual information processing and cognition in SCZ.

背景：精神分裂症（SCZ）和双相情感障碍（BD）与信息处理异常有关，包括视觉感知和认知障碍，这影响了日常功能。最近在健康样本中进行的研究表明，α峰频率（PAF）是视觉信息处理速度的电生理指标，也与认知能力相关。有证据表明SCZ患者的α峰频率减慢，但目前仍不清楚BD患者的α峰频率是否减慢，也不清楚α峰频率减慢是否与这些临床疾病的视觉感知和认知能力受损有关：本研究通过脑电图（EEG）记录了90名SCZ参与者、62名BD参与者和69名健康对照者的静息状态大脑活动（睁眼和闭眼）。大多数参与者还进行了视觉感知任务（后向遮蔽）和认知测试（MATRICS共识认知测试）：结果：与健康对照组相比，我们重复了之前的研究结果，即 SCZ 患者的 PAF 减少了。相比之下，BD 患者的 PAF 与健康对照组没有明显差异。此外，PAF 与 SCZ 的知觉和认知测量结果有明显的相关性，但与 BD 的相关性不大。在健康对照组中，PAF也与视觉感知相关，并与认知能力呈趋势性相关：这些结果表明，PAF 缺陷是 SCZ 的特征，而不是 BD 的特征，PAF 的个体差异与 SCZ 的视觉信息处理和认知异常有关。

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引用次数: 0

Guide for Authors 作者指南

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/S2451-9022(24)00290-8

引用次数: 0

Peak Alpha Frequency, Visual Perception, and Cognition in Schizophrenia 精神分裂症患者的阿尔法峰值频率、视觉感知和认知能力

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.09.007

Victor J. Pokorny

引用次数: 0

Macrostructural Brain Morphology as Moderator of the Relationship Between Pandemic-Related Stress and Internalizing Symptomology During COVID-19 in High-Risk Adolescents 大流行相关压力与高危青少年 COVID-19 期间内化症状之间关系的大脑形态宏观结构调节器。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.07.002

McKinley Pawlak , Jennifer Kemp , Signe Bray , Sneha Chenji , Melanie Noel , Kathryn A. Birnie , Frank P. MacMaster , Jillian Vinall Miller , Daniel C. Kopala-Sibley

Background

According to person-by-environment models, individual differences in traits may moderate the association between stressors and the development of psychopathology; however, findings in the literature have been inconsistent and little literature has examined adolescent brain structure as a moderator of the effects of stress on adolescent internalizing symptoms. The COVID-19 pandemic presented a unique opportunity to examine the associations between stress, brain structure, and psychopathology. Given links of cortical morphology with adolescent depression and anxiety, the current study investigated whether cortical morphology moderated the relationship between stress from the COVID-19 pandemic and the development of internalizing symptoms in familial high-risk adolescents.

Methods

Prior to the COVID-19 pandemic, 72 adolescents (27 male) completed a measure of depressive and anxiety symptoms and underwent magnetic resonance imaging. T1-weighted images were acquired to assess cortical thickness and surface area. Approximately 6 to 8 months after COVID-19 was declared a global pandemic, adolescents reported their depressive and anxiety symptoms and pandemic-related stress.

Results

Adjusting for pre-pandemic depressive and anxiety symptoms and stress, increased pandemic-related stress was associated with increased depressive but not anxiety symptoms. This relationship was moderated by cortical thickness and surface area in the anterior cingulate and cortical thickness in the medial orbitofrontal cortex such that increased stress was only associated with increased depressive and anxiety symptoms among adolescents with lower cortical surface area and higher cortical thickness in these regions.

Conclusions

Results further our understanding of neural vulnerabilities to the associations between stress and internalizing symptoms in general and during the COVID-19 pandemic in particular.

背景：根据 "因人因环境 "模型，个体特质的差异可能会缓和压力因素与心理病理学发展之间的关联；然而，文献中的研究结果并不一致，很少有文献研究青少年的大脑结构是压力对青少年内化症状影响的调节因素。COVID-19 大流行为研究压力、大脑结构和心理病理学之间的关联提供了一个独特的机会。考虑到大脑皮层形态与青少年抑郁和焦虑之间的联系，本研究调查了大脑皮层形态是否会调节 COVID-19 大流行所带来的压力与家族性高危青少年内化症状发展之间的关系：在 COVID-19 大流行之前，72 名青少年（27 岁）完成了抑郁和焦虑症状的测量，并接受了磁共振成像检查。采集 T1 加权图像以评估皮质厚度和表面积。在COVID-19被宣布为全球性流行病约6-8个月后，青少年报告了他们的抑郁和焦虑症状以及与流行病有关的压力：结果：在对大流行前的抑郁症状、焦虑症状和压力进行调整后，大流行相关压力的增加与抑郁症状的增加有关，但与焦虑症状无关。这种关系受前扣带回皮质厚度和表面积以及内侧眶额皮质厚度的调节，因此只有在这些区域皮质表面积较低而皮质厚度较高的青少年中，压力增加才与抑郁和焦虑症状的增加有关：研究结果进一步加深了我们对压力与内化症状之间的神经脆弱性的理解，尤其是在COVID-19大流行期间。

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引用次数: 0