Application of raman spectroscopy in the non-invasive diagnosis of urological diseases via urine

IF 3.1 3区医学 Q2 ONCOLOGY Photodiagnosis and Photodynamic Therapy Pub Date : 2025-01-13 DOI:10.1016/j.pdpdt.2025.104477

Ailiyaer Ainiwaer , ShuWen Sun , Ayinuer Bohetiyaer , Yuchao Liu , Yufeng Jiang , Wentao Zhang , JingCheng Zhang , Tianyuan Xu , Hanyang Chen , Xudong Yao , Chengyou Jia , Yang Yan

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Abstract

Objectives

The objective of this review is to provide a comprehensive overview of the utilization of Raman spectroscopy in urinary system diseases, highlighting its potential in non-invasive diagnostic methodologies for early diagnosis and prognostic assessment of urinary ailments.

Methods

We searched PubMed, Web of Science, and Google Scholar using 'raman,' 'bladder,' 'kidney,' 'prostate,' 'cancer,' 'infection,' 'stone or urinary calculi,' and 'urine or urinary,' along with 'AND' and 'OR' to refine our search. We excluded irrelevant articles and screened potential ones based on titles and abstracts before assessing the full texts for relevance and quality.

Findings

The findings indicate that RS can furnish data on biomolecules in urine, which is significant for non-invasive diagnostic approaches. It has shown potential within non-invasive diagnostic methodologies and is expected to play a pivotal role in the early diagnosis and prognostic assessment of urinary system diseases, such as malignancies, urinary tract infections, kidney diseases, urolithiasis, and other urinary conditions.

Conclusions

Raman spectroscopy has demonstrated significant potential in providing precise and rapid diagnostic approaches for clinical use in the context of urinary system diseases. Its ability to analyze biomolecules non-invasively positions it as an increasingly important tool in the early diagnosis and prognostic assessment of these conditions.

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拉曼光谱在尿路无创诊断泌尿系统疾病中的应用。

目的：本综述的目的是全面概述拉曼光谱在泌尿系统疾病中的应用，强调其在泌尿系统疾病的早期诊断和预后评估的无创诊断方法的潜力。方法：我们使用“拉曼”、“膀胱”、“肾脏”、“前列腺”、“癌症”、“感染”、“结石或尿路结石”和“尿或尿”以及“与”和“或”来搜索PubMed、Web of Science和谷歌Scholar，以完善我们的搜索。在评估全文的相关性和质量之前，我们排除了不相关的文章，并根据标题和摘要筛选了潜在的文章。结果：RS可以提供尿液中生物分子的数据，这对无创诊断方法具有重要意义。它在非侵入性诊断方法中显示出潜力，并有望在泌尿系统疾病的早期诊断和预后评估中发挥关键作用，如恶性肿瘤、尿路感染、肾脏疾病、尿石症和其他泌尿系统疾病。结论：拉曼光谱在泌尿系统疾病的临床应用中显示出了巨大的潜力，可以提供精确和快速的诊断方法。其无创分析生物分子的能力使其成为这些疾病的早期诊断和预后评估中越来越重要的工具。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.