Echocardiography of the right heart in pulmonary arterial hypertension: insights from the ULTRA RIGHT VALUE study.

European heart journal. Imaging methods and practice Pub Date : 2025-01-15 eCollection Date: 2025-01-01 DOI:10.1093/ehjimp/qyae121
Francesco Lo Giudice, Pilar Escribano-Subias, Khodr Tello, Grzegorz Kopec, Stefano Ghio, George Giannakoulas, Michele D'Alto, Domenico Filomena, Giovanna Manzi, Antonio Orlando, Alessandra Greco, Tommaso Recchioni, Selin Yildiz, Carmen Jiménez López-Guarch, Alejandro Cruz-Utrilla, Polykarpos Psochias, Vasiliki Patsiou, Jakub Stępniewski, Kamil Jonas, Laura Scelsi, Nils Kremer, Andrea Vergara, Carmine Dario Vizza, Robert Naeije, Roberto Badagliacca
{"title":"Echocardiography of the right heart in pulmonary arterial hypertension: insights from the ULTRA RIGHT VALUE study.","authors":"Francesco Lo Giudice, Pilar Escribano-Subias, Khodr Tello, Grzegorz Kopec, Stefano Ghio, George Giannakoulas, Michele D'Alto, Domenico Filomena, Giovanna Manzi, Antonio Orlando, Alessandra Greco, Tommaso Recchioni, Selin Yildiz, Carmen Jiménez López-Guarch, Alejandro Cruz-Utrilla, Polykarpos Psochias, Vasiliki Patsiou, Jakub Stępniewski, Kamil Jonas, Laura Scelsi, Nils Kremer, Andrea Vergara, Carmine Dario Vizza, Robert Naeije, Roberto Badagliacca","doi":"10.1093/ehjimp/qyae121","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>Outcome in pulmonary arterial hypertension (PAH) is determined by right ventricular (RV) function adaptation to increased afterload. Echocardiography is easily available to assist bedside evaluation of the RV. However, no agreement exists about the feasibility and most relevant measurements. We therefore examined the feasibility, quality, and clinical correlations of standard echocardiographic variables in the evaluation of PAH.</p><p><strong>Methods and results: </strong>The present multicentric study collected echocardiographic examinations with centralized reading in 401 patients with prevalent PAH. Clinical variables, as World Health Organization (WHO) functional class (FC), 6 min walk distance (6MWD), brain natriuretic peptide (BNP)/NT-proBNP, invasive haemodynamics, the European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines-derived four-strata score, and the United States Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) 2.0 score, were also collected. Echocardiographic measurements showed variable degrees of dilation of the right heart as assessed by right atrial and RV areas, altered indices of systolic function such as tricuspid annular plane systolic excursion (TAPSE), fractional area change, or 2D strain, and derived estimates of RV to pulmonary artery (PA) coupling by referring these measurements to systolic PA pressure (sPAP). All these measurements were feasible. All measurements of right heart dimensions and function, particularly TAPSE/sPAP, were correlated with WHO-FC, 6MWD, BNP/NT-proBNP, invasive haemodynamics, and ESC/ERS and REVEAL 2.0 scores.</p><p><strong>Conclusion: </strong>The present quality-controlled data from a network of PAH referral centres offer the background needed for further evaluation of the added value of echocardiography to currently recommended risk assessments in PAH.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyae121"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733976/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European heart journal. Imaging methods and practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/ehjimp/qyae121","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Aims: Outcome in pulmonary arterial hypertension (PAH) is determined by right ventricular (RV) function adaptation to increased afterload. Echocardiography is easily available to assist bedside evaluation of the RV. However, no agreement exists about the feasibility and most relevant measurements. We therefore examined the feasibility, quality, and clinical correlations of standard echocardiographic variables in the evaluation of PAH.

Methods and results: The present multicentric study collected echocardiographic examinations with centralized reading in 401 patients with prevalent PAH. Clinical variables, as World Health Organization (WHO) functional class (FC), 6 min walk distance (6MWD), brain natriuretic peptide (BNP)/NT-proBNP, invasive haemodynamics, the European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines-derived four-strata score, and the United States Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) 2.0 score, were also collected. Echocardiographic measurements showed variable degrees of dilation of the right heart as assessed by right atrial and RV areas, altered indices of systolic function such as tricuspid annular plane systolic excursion (TAPSE), fractional area change, or 2D strain, and derived estimates of RV to pulmonary artery (PA) coupling by referring these measurements to systolic PA pressure (sPAP). All these measurements were feasible. All measurements of right heart dimensions and function, particularly TAPSE/sPAP, were correlated with WHO-FC, 6MWD, BNP/NT-proBNP, invasive haemodynamics, and ESC/ERS and REVEAL 2.0 scores.

Conclusion: The present quality-controlled data from a network of PAH referral centres offer the background needed for further evaluation of the added value of echocardiography to currently recommended risk assessments in PAH.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
肺动脉高压右心超声心动图:来自ULTRA right VALUE研究的见解。
目的:肺动脉高压(PAH)的预后取决于右心室(RV)功能对后负荷增加的适应。超声心动图很容易用于辅助心室的床边评估。然而,关于可行性和最相关的测量方法尚无一致意见。因此,我们检查了评价PAH的标准超声心动图变量的可行性、质量和临床相关性。方法和结果:本多中心研究收集了401例流行PAH患者的超声心动图集中读数。临床变量,如世界卫生组织(WHO)功能分类(FC)、6分钟步行距离(6MWD)、脑利钠肽(BNP)/NT-proBNP、侵入性血流动力学、欧洲心脏病学会(ESC)/欧洲呼吸学会(ERS)指南衍生的四层评分,以及美国早期和长期肺动脉高血压疾病管理评估登记(REVEAL) 2.0评分。超声心动图测量显示,通过右心房和右心室面积评估的右心脏扩张程度不同,收缩功能指标改变,如三尖瓣环平面收缩偏移(TAPSE),分数面积变化或2D应变,以及通过参考收缩压(sPAP)测量得出的右心室与肺动脉(PA)耦合的估计。所有这些测量都是可行的。右心尺寸和功能的所有测量,特别是TAPSE/sPAP,与WHO-FC、6MWD、BNP/NT-proBNP、侵入性血流动力学、ESC/ERS和REVEAL 2.0评分相关。结论:目前来自多环芳烃转诊中心网络的质量控制数据为进一步评估超声心动图对目前推荐的多环芳烃风险评估的附加价值提供了必要的背景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Cardiac imaging highlights from European Society of Cardiology 2024: the future is within our grasp! Clinical significance of the estimation of pulmonary-right ventricular uncoupling in patients with transthyretin amyloid cardiomyopathy. Coronary complications in Kawasaki disease: giant aneurysms and thrombosis leading to myocardial infarction. Echocardiography of the right heart in pulmonary arterial hypertension: insights from the ULTRA RIGHT VALUE study. How to perform and evaluate a myocardial perfusion imaging by computed tomography.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1