An implantable system for opioid safety.

Device Pub Date : 2024-10-18 Epub Date: 2024-08-14 DOI:10.1016/j.device.2024.100517
Hen-Wei Huang, Peter R Chai, Seungho Lee, Tom Kerssemakers, Ali Imani, Jack Chen, Marco Heim, Jessica Y Bo, Adam Wentworth, Fokion T Sanoudos-Dramaliotis, Ian Ballinger, Saurav Maji, Matt Murphy, Alexander Alexiev, Gloria H Kang, Niora Fabian, Josh Jenkins, Andrew Pettinari, Keiko Ishida, Jason Li, Siheng Sean You, Alison M Hayward, Anantha Chandrakasan, Giovanni Traverso
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引用次数: 0

Abstract

Naloxone can effectively rescue victims from opioid overdose, but less than 5% survive due to delayed or absent first responder intervention. Current overdose reversal systems face key limitations, including low user adherence, false positive detection, and slow antidote delivery. Here, we describe a subcutaneously implanted robotic first responder to overcome these challenges. This implantable system for opioid safety continuously monitors vital signs, detecting opioid overdose through an algorithm analyzing the interplay of cardiorespiratory responses. To address battery concerns with continuous monitoring and multi-sensing modality, an adaptive algorithm dynamically adjusts sensor resolution, reducing the need for frequent charging. Furthermore, the implant includes an ultra-rapid naloxone delivery pump, delivering the 10-mg antidote within 10 s. In animal trials, the robotic first responder successfully revived 96% of overdosed pigs (n = 25) within 3.2 min, showcasing its potential to dramatically improve survival rates and combat the opioid epidemic.

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阿片类药物安全的植入式系统。
纳洛酮可以有效地拯救阿片类药物过量的受害者,但由于延迟或缺乏第一响应者干预,只有不到5%的人存活。目前的药物过量逆转系统面临着主要的局限性,包括用户依从性低、假阳性检测和解毒剂递送缓慢。在这里,我们描述了一个皮下植入的机器人第一反应来克服这些挑战。这种用于阿片类药物安全的植入式系统持续监测生命体征,通过算法分析心肺反应的相互作用来检测阿片类药物过量。为了解决持续监测和多传感模式下的电池问题,一种自适应算法动态调整传感器分辨率,减少了频繁充电的需要。此外,植入物包括一个超快速纳洛酮输送泵,在10秒内输送10毫克的解毒剂。在动物试验中,机器人第一响应者在3.2分钟内成功地使96%的过量用药猪(n = 25)苏醒,显示出其显著提高存活率和对抗阿片类药物流行的潜力。
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