Pub Date : 2024-12-20Epub Date: 2024-08-21DOI: 10.1016/j.device.2024.100514
Ian R Woodward, Yinkui Yu, Catherine A Fromen
Modeling aerosol dynamics in the airways is challenging, and most modern personalized in vitro tools consider only a single inhalation maneuver through less than 10% of the total lung volume. Here, we present an in vitro modeling pipeline to produce a device that preserves patient-specific upper airways while approximating deeper airways, capable of achieving total lung volumes over 7 liters. The modular system, called TIDAL, includes tunable inhalation and exhalation breathing capabilities with resting flow rates up to 30 liters per minute. We show that the TIDAL system is easily coupled with industrially and clinically relevant devices for aerosol therapeutics. Using a vibrating mesh nebulizer, we report central-to-peripheral (C:P) aerosol deposition measurements aligned with both in vivo and in silico benchmarks. These findings underscore the effectiveness of the TIDAL model in predicting airway deposition dynamics for inhalable therapeutics.
{"title":"Experimental Full-volume Airway Approximation for Assessing Breath-dependent Regional Aerosol Deposition.","authors":"Ian R Woodward, Yinkui Yu, Catherine A Fromen","doi":"10.1016/j.device.2024.100514","DOIUrl":"10.1016/j.device.2024.100514","url":null,"abstract":"<p><p>Modeling aerosol dynamics in the airways is challenging, and most modern personalized <i>in vitro</i> tools consider only a single inhalation maneuver through less than 10% of the total lung volume. Here, we present an <i>in vitro</i> modeling pipeline to produce a device that preserves patient-specific upper airways while approximating deeper airways, capable of achieving total lung volumes over 7 liters. The modular system, called TIDAL, includes tunable inhalation and exhalation breathing capabilities with resting flow rates up to 30 liters per minute. We show that the TIDAL system is easily coupled with industrially and clinically relevant devices for aerosol therapeutics. Using a vibrating mesh nebulizer, we report central-to-peripheral (C:P) aerosol deposition measurements aligned with both <i>in vivo</i> and <i>in silico</i> benchmarks. These findings underscore the effectiveness of the TIDAL model in predicting airway deposition dynamics for inhalable therapeutics.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"2 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-18Epub Date: 2024-08-14DOI: 10.1016/j.device.2024.100517
Hen-Wei Huang, Peter R Chai, Seungho Lee, Tom Kerssemakers, Ali Imani, Jack Chen, Marco Heim, Jessica Y Bo, Adam Wentworth, Fokion T Sanoudos-Dramaliotis, Ian Ballinger, Saurav Maji, Matt Murphy, Alexander Alexiev, Gloria H Kang, Niora Fabian, Josh Jenkins, Andrew Pettinari, Keiko Ishida, Jason Li, Siheng Sean You, Alison M Hayward, Anantha Chandrakasan, Giovanni Traverso
Naloxone can effectively rescue victims from opioid overdose, but less than 5% survive due to delayed or absent first responder intervention. Current overdose reversal systems face key limitations, including low user adherence, false positive detection, and slow antidote delivery. Here, we describe a subcutaneously implanted robotic first responder to overcome these challenges. This implantable system for opioid safety continuously monitors vital signs, detecting opioid overdose through an algorithm analyzing the interplay of cardiorespiratory responses. To address battery concerns with continuous monitoring and multi-sensing modality, an adaptive algorithm dynamically adjusts sensor resolution, reducing the need for frequent charging. Furthermore, the implant includes an ultra-rapid naloxone delivery pump, delivering the 10-mg antidote within 10 s. In animal trials, the robotic first responder successfully revived 96% of overdosed pigs (n = 25) within 3.2 min, showcasing its potential to dramatically improve survival rates and combat the opioid epidemic.
{"title":"An implantable system for opioid safety.","authors":"Hen-Wei Huang, Peter R Chai, Seungho Lee, Tom Kerssemakers, Ali Imani, Jack Chen, Marco Heim, Jessica Y Bo, Adam Wentworth, Fokion T Sanoudos-Dramaliotis, Ian Ballinger, Saurav Maji, Matt Murphy, Alexander Alexiev, Gloria H Kang, Niora Fabian, Josh Jenkins, Andrew Pettinari, Keiko Ishida, Jason Li, Siheng Sean You, Alison M Hayward, Anantha Chandrakasan, Giovanni Traverso","doi":"10.1016/j.device.2024.100517","DOIUrl":"10.1016/j.device.2024.100517","url":null,"abstract":"<p><p>Naloxone can effectively rescue victims from opioid overdose, but less than 5% survive due to delayed or absent first responder intervention. Current overdose reversal systems face key limitations, including low user adherence, false positive detection, and slow antidote delivery. Here, we describe a subcutaneously implanted robotic first responder to overcome these challenges. This implantable system for opioid safety continuously monitors vital signs, detecting opioid overdose through an algorithm analyzing the interplay of cardiorespiratory responses. To address battery concerns with continuous monitoring and multi-sensing modality, an adaptive algorithm dynamically adjusts sensor resolution, reducing the need for frequent charging. Furthermore, the implant includes an ultra-rapid naloxone delivery pump, delivering the 10-mg antidote within 10 s. In animal trials, the robotic first responder successfully revived 96% of overdosed pigs (<i>n</i> = 25) within 3.2 min, showcasing its potential to dramatically improve survival rates and combat the opioid epidemic.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"2 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.device.2024.100408
Sahiba Bano, Raju Chetty, Jayachandran Babu, T. Mori
{"title":"Mg3(Sb,Bi)2-based materials and devices rivaling bismuth telluride for thermoelectric power generation and cooling","authors":"Sahiba Bano, Raju Chetty, Jayachandran Babu, T. Mori","doi":"10.1016/j.device.2024.100408","DOIUrl":"https://doi.org/10.1016/j.device.2024.100408","url":null,"abstract":"","PeriodicalId":101324,"journal":{"name":"Device","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.device.2024.100463
Max Shtein, Matthew Shlian
{"title":"Cross-cutting: Kirigami art and devices","authors":"Max Shtein, Matthew Shlian","doi":"10.1016/j.device.2024.100463","DOIUrl":"https://doi.org/10.1016/j.device.2024.100463","url":null,"abstract":"","PeriodicalId":101324,"journal":{"name":"Device","volume":"8 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.device.2024.100468
C. Doerrer, Michael Metzler, Guillaume Matthews, Junfu Bu, Dominic Spencer-Jolly, Peter G. Bruce, Mauro Pasta, Patrick S. Grant
{"title":"Spraying Li6PS5Cl and silver-carbon multilayers to facilitate large-scale fabrication of all-solid-state batteries","authors":"C. Doerrer, Michael Metzler, Guillaume Matthews, Junfu Bu, Dominic Spencer-Jolly, Peter G. Bruce, Mauro Pasta, Patrick S. Grant","doi":"10.1016/j.device.2024.100468","DOIUrl":"https://doi.org/10.1016/j.device.2024.100468","url":null,"abstract":"","PeriodicalId":101324,"journal":{"name":"Device","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.device.2024.100401
Pengju Li, Saehyun Kim, B. Tian
{"title":"Beyond 25 years of biomedical innovation in nano-bioelectronics","authors":"Pengju Li, Saehyun Kim, B. Tian","doi":"10.1016/j.device.2024.100401","DOIUrl":"https://doi.org/10.1016/j.device.2024.100401","url":null,"abstract":"","PeriodicalId":101324,"journal":{"name":"Device","volume":"268 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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