The Novel Role of GDI2: A Mini-Review.

Annals of medicine and medical research Pub Date : 2024-01-01 Epub Date: 2024-08-17
Y Wu, G Y Chen
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Abstract

GDP Dissociation Inhibitor 2 (GDI2) plays a crucial role in maintaining cellular homeostasis by regulating Rab GTPases involved in vesicular transport. This review highlights the importance of GDI2 in various biological processes, particularly embryonic development, apoptosis regulation, cancer, and immune responses. GDI2's essential function in embryonic development is evidenced by the embryonic lethality observed in GDI2 knockout mice. In apoptosis, GDI2 is implicated in the caspase pathway, influencing cell survival and death. In cancer, dysregulation of GDI2 contributes to altered tumor cell-macrophage interactions, promoting inflammation and metastasis, with GDI2 acting as a metastasis suppressor in certain cancers. Furthermore, GDI2's role in immune responses, particularly during bacterial infections, and its potential therapeutic implications in conditions like Alzheimer's disease are explored. This review emphasizes the need for further research to elucidate the molecular mechanisms of GDI2 and its potential as a therapeutic target in developmental disorders, cancer, and immune-related diseases.

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GDI2的新作用:一个小回顾。
GDP解离抑制剂2 (GDI2)通过调节参与囊泡运输的Rab gtpase在维持细胞稳态中起着至关重要的作用。这篇综述强调了GDI2在各种生物过程中的重要性,特别是胚胎发育、细胞凋亡调节、癌症和免疫反应。在GDI2基因敲除小鼠中观察到的胚胎致死性证明了GDI2在胚胎发育中的重要功能。在细胞凋亡中,GDI2参与caspase通路,影响细胞存活和死亡。在癌症中,GDI2的失调有助于改变肿瘤细胞与巨噬细胞的相互作用,促进炎症和转移,GDI2在某些癌症中作为转移抑制因子。此外,GDI2在免疫反应中的作用,特别是在细菌感染期间,及其在阿尔茨海默病等疾病中的潜在治疗意义也被探讨。这篇综述强调需要进一步研究阐明GDI2的分子机制及其作为发育障碍、癌症和免疫相关疾病的治疗靶点的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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