The Effect of Human Adipose Stem Cell-Conditioned Medium (hASC-CM) in Photoaged Skin.

IF 1.1 Q4 CELL & TISSUE ENGINEERING Journal of Stem Cells & Regenerative Medicine Pub Date : 2024-11-20 eCollection Date: 2024-01-01 DOI:10.46582/jsrm.2002006
Winawati Eka Putri, Meidyta Sinantryana Widyaswari, Cita Rosita Sigit Prakoeswa, David Sajid Muhammad, Deny Febriwijaya Romadhani, Nadia Nisaussholihah
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引用次数: 0

Abstract

Background: Ultraviolet (UV) exposure causes direct and indirect damages to skin structures. Human adipose stem cell-conditioned medium (hASC-CM) is a collection of several soluble factors, such as cytokines, chemokines, and Growth Factors (GF), secreted by almost all living cells in the extracellular space which support wound healing and skin rejuvenation. Objective: To determine the effects of human adipose stem cell-conditioned medium (hASC-CM) in photoaged skin and evaluate photoaging improvement after treatment. Methods: An experimental randomized controlled trial was performed, involving 64 photoaged subjects at the Dermato-Venereology Outpatient Clinic of Jemursari Islamic Hospital Surabaya from March to June 2022. The subjects were divided into the hASC-CM group and vehiculum (control) group. Patients' transepidermal water loss value, skin tone, and Glogau score in weeks 0, 4, and 8 were evaluated. The data were then analyzed using Mann-Whitney test (p<0.05). Results: All subjects had Glogau scale of III (89.6%) with mean ± SD (3.121 ± 0.329). hASC-CM group showed higher improvements in the pore, wrinkle, spot polarized, spot UV parameters and skin tone compared to vehiculum group(p<0.05). Conclusions: hASC-CM effectively improved all parameters observed. The limitation of this research was on the lack of long-term follow-up after treatment. This research had received an ethical permit from The Ethical Committee Board of Jemursari Islamic Hospital Surabaya under letter 006/KEPK-RSISJS/II/2022.

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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
5
审稿时长
14 weeks
期刊最新文献
(PASRM)-2024: I. Stem cell therapies for the cornea. Critical criteria for improvising the efficacy of transplanted cells; Significance of route of administration and microenvironment at the target site. I. IDC Key-note Lecture: Influence of gut microbiome in Duchenne muscular dystrophy. The Effect of Human Adipose Stem Cell-Conditioned Medium (hASC-CM) in Photoaged Skin. Therapeutic Potential of Different Injection Methods for Bone Marrow Mesenchymal Stem Cell Transplantation in Buslfan-Induced Male Rat Infertility.
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