Victor Augusto Ramos Fernandes, Gabriela Pereira Dos Santos, Amilton Iatecola, Daniela Vieira Buchaim, Ionaly Judith Faria Garcia, Carlos Henrique Bertoni Reis, Lívia Maluf Menegazzo Bueno, Bruna Trazzi Pagani, Rogerio Leone Buchaim, Marcelo Rodrigues da Cunha
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引用次数: 0
Abstract
Background/Objectives: Duchenne muscular dystrophy (DMD) is a genetic disease characterized by a lack of dystrophin caused by mutations in the DMD gene, and some minor cases are due to decreased levels of dystrophin, leading to muscle weakness and motor impairment. Creatine supplementation has demonstrated several benefits for the muscle, such as increased strength, enhanced tissue repair, and improved ATP resynthesis. This preliminary study aimed to investigate the effects of creatine on the gastrocnemius muscle in dystrophy muscle (MDX) and healthy C57BL/10 mice. Methods: Twenty MDX and C57Bl/10 mice were organized into groups and supplemented or not with creatine in a dosage of 0.3 mg for 8 weeks. Gastrocnemius tissue was analyzed using histomorphology and histomorphometric techniques. Results: The results demonstrated potential anti-inflammatory effects of creatine, with less observation of inflammatory infiltrates, the preservation of intramuscular glycogen, and reduction in tissue fibrosis in supplemented animals. Conclusions: These findings suggest that creatine may enhance tissue function and slow the progression of DMD. However, further research, with more analysis, is needed to elucidate molecular mechanisms underlying creatine's effects on reducing mononuclear leukocytes and its role in mitigating tissue fibrosis.
Jennifer Soutter BSc PhD, Neil Hamilton BA Dip BA PGCE, Peter Russell BA, Chris Russell, Kate Bushby MD FRCP, Patricia Sloper BA MA PhD, Kim Bartlett BSc PhD FRCPCH
期刊介绍:
Pathophysiology is an international journal which publishes papers in English which address the etiology, development, and elimination of pathological processes. Contributions on the basic mechanisms underlying these processes, model systems and interdisciplinary approaches are strongly encouraged.