The Effect of Silver Diamine Fluoride Combined with Potassium Iodide and Sodium Fluoride on the Remineralisation of Hydroxyapatite.

IF 1.4 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Oral health & preventive dentistry Pub Date : 2025-01-23 DOI:10.3290/j.ohpd.c_1811

Yan Ma, Haoran Chen, Yan He, Liming Tao

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Abstract

Purpose: To compare remineralisation efficacy between silver diamine fluoride (SDF) combined with potassium iodide (KI) and sodium fluoride (NaF) varnish using hydroxyapatite (HAP) artificial white spot lesions (AWSLs) demineralisation model.

Materials and methods: A total of 25 HAP disks was randomly divided into five groups (n = 5): baseline, AWSLs, deionized water (DW), SDF-KI or F-varnish. After AWSLs were developed, the specimen was treated with either deionized water, SDF-KI or F-varnish. These specimens were then subjected to pH-cycling for 7 days. The remineralisation potential was assessed by measuring changes in Vickers hardness (VHN). Morphological and compositional analyses were conducted using scanning electron microscopy (SEM), energy dispersive x-ray (EDX), x-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR). Ion-selective electrodes (ISE) were utilised to measure calcium and fluoride release.

Results: SDF-KI treatment demonstrated statistically significant remineralisation potential in restoring VHN values vs baseline levels (p 0.001). SEM, EDX, and XRD analyses confirmed the mineral deposits to indicate remineralisation. The uptake of calcium was higher in SDF-KI than in F-varnish (p = 0.011). The fluorapatite (FAP) and fluoride-substituted apatite formation were validated by FTIR and XRD analyses.

Conclusion: SDF-KI and F-varnish applications are both effective in promoting remineralisation on HAP disks. The application of SDF-KI affected the physicochemical and mechanical properties of demineralised HAP. The SDF-KI showed more formation of fluoride-substituted apatite and is effective in the hardening of demineralised HAP.

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氟化二胺银与碘化钾、氟化钠复合对羟基磷灰石再矿化的影响。

目的：采用羟基磷灰石（HAP）人工白斑病变（AWSLs）脱矿模型，比较氟化二胺银（SDF）联合碘化钾（KI）和氟化钠（NaF）清漆的再矿化效果。材料与方法：25个HAP盘随机分为5组（n = 5）：基线、awsl、去离子水（DW）、SDF-KI或f -清漆。awsl形成后，用去离子水、SDF-KI或f -清漆处理样品。然后将这些标本进行ph循环7天。通过测量维氏硬度（VHN）的变化来评估再矿化电位。利用扫描电镜（SEM）、能量色散x射线（EDX）、x射线衍射（XRD）和傅里叶变换红外光谱（FTIR）对样品进行形貌和成分分析。离子选择电极（ISE）用于测量钙和氟化物的释放。结果：与基线水平相比，SDF-KI治疗在恢复VHN值方面显示出统计学上显著的再矿化潜力（p 0.001）。SEM， EDX和XRD分析证实了矿床表明再矿化。SDF-KI组的钙摄取高于f -清漆组（p = 0.011）。FTIR和XRD分析证实了氟磷灰石（FAP）和氟取代磷灰石的形成。结论：SDF-KI和f -清漆均能有效促进HAP盘的再矿化。SDF-KI的应用影响了脱矿HAP的物理化学和力学性能。SDF-KI表现出更多的氟取代磷灰石的形成，对脱矿HAP的硬化有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral health & preventive dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinicians, general practitioners, teachers, researchers, and public health administrators will find this journal an indispensable source of essential, timely information about scientific progress in the fields of oral health and the prevention of caries, periodontal diseases, oral mucosal diseases, and dental trauma. Central topics, including oral hygiene, oral epidemiology, oral health promotion, and public health issues, are covered in peer-reviewed articles such as clinical and basic science research reports; reviews; invited focus articles, commentaries, and guest editorials; and symposium, workshop, and conference proceedings.