Impact of Sjögren's disease on quality of sexual life using the Qualisex score.

IF 4.7 2区医学 Q1 RHEUMATOLOGY RMD Open Pub Date : 2025-01-21 DOI:10.1136/rmdopen-2024-004693

Alexandra Kachaner, Raphaele Seror, Véronique Le Guern, Philippe Dieudé, Jacques-Eric Gottenberg, Eric Hachulla, Valérie Devauchelle-Pensec, Aleth Perdriger, Emanuelle Dernis, Marion Couderc, Sophie Berville, Xavier Mariette, Rakiba Belkhir, Gaetane Nocturne

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Abstract

Objective: This study aimed to assess the impact of Sjögren disease (SjD) on the quality of sexual life and its determinants using the Qualisex questionnaire.

Methods: The Qualisex questionnaire was administered to participants within the ASSESS cohort, a French national multicentric prospective cohort of individuals with SjD. Patients' characteristics and psychometric evaluations were also collected.

Results: Among the 395 patients of the cohort, 92 (23%) completed the questionnaire, with a median age of 56 (44-59) years and a female ratio of 92% (85/92). The median Qualisex score was 3.4 (1.1-5.9).Comparing the first and last quartiles of the Qualisex score, a worst sexual satisfaction was associated with older age (median (IQR) 58 (52-65) vs 52 (41-56) years, p=0.005), higher EULAR Sjögren's disease Patient Reported Index (ESSPRI) (6.8 (5.7-7.7) vs 4.3 (2.8-5.3), p<0.0001) lower SF-36 mental and physical scores (respectively, 43 (38-46) vs 49 (47-53), p=0.0035 and 31 (29-35) vs 35 (30-37), p=0.035), higher Depression and Anxiety scores (HADS) (respectively, 9 (7-11) vs 2 (1-4), p<0.0001 and 11 (8-14) vs 7 (4-10), p=0.006). Interestingly, EULAR Sjögren's disease Disease Activity Index (ESSDAI) score did not differ significantly (4 (1-10) vs 2.5 (1.8-4), p=0.35). In a multivariable analysis, the Qualisex score remained strongly associated with a higher HADS depression score and, to a lesser extent, with a higher ESSPRI. The inability to obtain a score was associated with older age.

Conclusion: In SjD patients, sexual satisfaction assessed with the Qualisex score, was strongly associated with depression and, to lesser extent, with ESSPRI, but not with systemic activity.

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使用Qualisex评分对Sjögren疾病对性生活质量的影响。

目的：本研究旨在利用Qualisex问卷评估Sjögren疾病（SjD）对性生活质量的影响及其决定因素。方法：对法国国家多中心SjD个体前瞻性队列——evaluate队列中的参与者进行Qualisex问卷调查。还收集了患者的特征和心理测量评估。结果：该队列395例患者中，92例（23%）完成了问卷调查，年龄中位数为56（44-59）岁，女性比例为92%（85/92）。Qualisex评分中位数为3.4（1.1-5.9）。比较Qualisex评分的前四分位数和后四分位数，最差的性满意度与年龄较大(中位数（IQR） 58 (52-65) vs 52（41-56）岁，p=0.005)，较高的EULAR Sjögren疾病患者报告指数（ESSPRI） (6.8 （5.7-7.7) vs 4.3(2.8-5.3)）相关。结论：在SjD患者中，用Qualisex评分评估的性满意度与抑郁密切相关，在较小程度上与ESSPRI相关，但与全身活动无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

RMD Open RHEUMATOLOGY-

CiteScore

7.30

自引率

6.50%

发文量

205

审稿时长

14 weeks

期刊介绍： RMD Open publishes high quality peer-reviewed original research covering the full spectrum of musculoskeletal disorders, rheumatism and connective tissue diseases, including osteoporosis, spine and rehabilitation. Clinical and epidemiological research, basic and translational medicine, interesting clinical cases, and smaller studies that add to the literature are all considered.