Mitochondrial NAD+ transporter SLC25A51 linked to human aortic disease

IF 12.6 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Nature cardiovascular research Pub Date : 2025-01-22 DOI:10.1038/s44161-024-00599-6
Gabriel K. Adzika, Ricardo A. Velázquez Aponte, Joseph A. Baur
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Abstract

An extensive molecular characterization of 150 human thoracic aorta specimens followed by genetic association studies and preclinical work in mice implicates the mitochondrial NAD+ transporter SLC25A51 in the pathogenesis of aortic disease.

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线粒体NAD+转运体SLC25A51与人类主动脉疾病有关
通过对150例人类胸主动脉标本进行广泛的分子表征、遗传关联研究和小鼠临床前工作,我们发现线粒体NAD+转运体SLC25A51参与了主动脉疾病的发病机制。
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