Fructose-Modified Chitosan/Gelatin 3D Composite Sponge for Enhanced Rapid Hemostasis

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomacromolecules Pub Date : 2025-02-10 DOI:10.1021/acs.biomac.4c01634

Hongyan Wang , Lin Shi , Zhongxu Zhang , Long Chen , Xinli Xu , Weiwei Ding , Chuntao Chen , Dongping Sun

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Abstract

Managing uncontrolled and noncompressible bleeding presents a major challenge in emergency trauma care. Methods to halt bleeding quickly and efficiently, without applying direct pressure on the wound, have become a key focus of research. Herein, a novel fructose-modified chitosan/gelatin composite sponge has been developed, exhibiting high elasticity, low rebound pressure, and excellent cell compatibility. This material can rapidly return to its original form in around 1.5 s after being compressed by 80% upon contact with water. Additionally, experimental results from a rat liver wound model demonstrated that it exhibited a clear hemostatic effect. The hemostatic time was shortened from 204 ± 15.35 s to 53.3 ± 6.54 s, and the blood loss was reduced from 867 ± 153.15 mg to 187 ± 61.06 mg. Moreover, it can promote tissue healing by inhibiting the production of inflammatory factors including TNF-α, MCP-1, and IL-6. This material offers an effective solution for noncompressible tissue injuries.

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果糖改性壳聚糖/明胶三维复合海绵增强快速止血。

处理不受控制和不可压缩性出血是急诊创伤护理的主要挑战。如何在不直接压迫伤口的情况下快速有效地止血，已成为研究的重点。本文研制了一种新型的果糖改性壳聚糖/明胶复合海绵，具有高弹性、低回弹压力和良好的细胞相容性。这种材料与水接触后被压缩80%，在1.5 s左右即可迅速恢复原状。此外，大鼠肝损伤模型的实验结果表明，它具有明显的止血作用。止血时间由204±15.35 s缩短至53.3±6.54 s，出血量由867±153.15 mg减少至187±61.06 mg。此外，它还可以通过抑制TNF-α、MCP-1和IL-6等炎症因子的产生来促进组织愈合。这种材料为不可压缩组织损伤提供了有效的解决方案。

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文献相关原料

公司名称

产品信息

阿拉丁

TritonX-100

阿拉丁

Gelatin

阿拉丁

Chitosan powder

来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.