Recent advance for enantiorecognition of chiral drugs sensing: Electrochemical, electrochemiluminescent and photoelectrochemical application

IF 10.5 1区生物学 Q1 BIOPHYSICS Biosensors and Bioelectronics Pub Date : 2025-04-01 Epub Date: 2025-01-08 DOI:10.1016/j.bios.2025.117141

Qianxiu Pan , Hong Guan , Wenjing Xu , Jingjing Zhao , Yan Liu , Lin Cui , Jin Zhou

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Abstract

Chiral isomers show different behaviours and properties in physiological activities. It is of great significance to find productive approach to realize the recognition of enantiomers, which is a key issue in biochemical and pharmaceutical fields. Nowadays, chiral identification can be successfully achieved according to the discrepancies of special signals correlated with different enantiomers of multiple electrode structures. Electrochemical technologies have attracted wide interest in enantioselective analysis because of its unique merits, such as the economic and miniaturized instruments, simplified and environmental-friendly sample preparations. This review summarizes the development trends of electrochemical sensing in the enantiospecific analysis of chiral drugs, expounds the enantiospecific recognition mechanism between chiral selector and target enantiomers based on general electrochemical, electrochemiluminescent and photoelectrochemical sensors, respectively. In addition, this review attempts to predict the future application of electrochemical, electrochemiluminescent and photoelectrochemical-based technologies in the enantioselective recognition and detection.

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手性药物传感对映体识别的研究进展：电化学、电化学发光和光电化学应用。

手性异构体在生理活动中表现出不同的行为和性质。寻找有效的方法实现对映体的识别是生物化学和制药领域的关键问题，具有重要意义。目前，根据不同电极结构的对映体所对应的特殊信号的差异，可以成功地实现手性识别。电化学技术以其经济、小型化、样品制备简单、环境友好等独特的优点引起了对映选择分析领域的广泛关注。综述了电化学传感在手性药物对映体分析中的发展趋势，阐述了基于普通电化学传感器、电化学发光传感器和光电电化学传感器的手性选择器与靶对映体的对映体识别机理。此外，本文还对电化学、电化学发光和基于光电化学的技术在对映体选择性识别和检测中的应用前景进行了展望。

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来源期刊

Biosensors and Bioelectronics 工程技术-电化学

CiteScore

20.80

自引率

7.10%

发文量

1006

审稿时长

29 days

期刊介绍： Biosensors & Bioelectronics, along with its open access companion journal Biosensors & Bioelectronics: X, is the leading international publication in the field of biosensors and bioelectronics. It covers research, design, development, and application of biosensors, which are analytical devices incorporating biological materials with physicochemical transducers. These devices, including sensors, DNA chips, electronic noses, and lab-on-a-chip, produce digital signals proportional to specific analytes. Examples include immunosensors and enzyme-based biosensors, applied in various fields such as medicine, environmental monitoring, and food industry. The journal also focuses on molecular and supramolecular structures for enhancing device performance.