The COL1A1 rs1800012 polymorphism is associated with osteoporosis or fracture risk: a meta-analysis of 30 studies.

IF 1 Q3 EMERGENCY MEDICINE International Journal of Burns and Trauma Pub Date : 2024-12-15 eCollection Date: 2024-01-01 DOI:10.62347/KKAM3344

Pengcheng Xu, Yuzhong Wang, Xing Wu, Wei Wang, Qingwen Wang, Wei Lin, Zhisheng Zhang, Ming Li

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Abstract

Objectives: Osteoporosis is a complex disease that is influenced by several genetic markers. Many studies have examined the link between the COL1A1 gene rs1800012 polymorphism and osteoporosis risk. However, the findings of these studies are contradictory. Therefore, we performed a meta-analysis to aggregate additional information and obtain increased statistical power to more efficiently examine this correlation.

Methods: A meta-analysis was conducted to evaluate the association between the COL1A1 rs1800012 (G > T) polymorphism and the risk of osteoporosis or fracture. A total of 30 case-control studies were included that contained 2,943 patients and 4,724 control subjects. The Stata 11.0 statistical software package was used to evaluate the odds ratio (OR) and 95% confidence interval.

Results: Overall, the recessive and homozygote models showed no heterogeneity, with a significant fixed effect pooled OR (P < 0.001). Moreover, the allelic (P < 0.001), dominant (P < 0.001), and heterozygote (P = 0.002) models were associated with a significantly increased risk of osteoporosis or fracture by random effect analysis. Sub-group analyses revealed that all the hereditary models showed an increased risk of osteoporosis or fracture in a European population. Additionally, we found a significant association in the dominant (P = 0.035) and heterozygote (P = 0.030) models in North Americans. In addition, we observed an association between COL1A1 and osteoporosis and fracture risk.

Conclusions: Combined with data from previous studies, this meta-analysis suggested that COL1A1 is associated with osteoporosis or fracture risk.

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COL1A1 rs1800012多态性与骨质疏松或骨折风险相关：一项30项研究的荟萃分析

目的：骨质疏松症是一种受多种遗传标记影响的复杂疾病。许多研究已经检查了COL1A1基因rs1800012多态性与骨质疏松症风险之间的联系。然而，这些研究的结果是矛盾的。因此，我们进行了荟萃分析，以收集额外的信息，并获得更有效地检验这种相关性的统计能力。方法：通过荟萃分析评估COL1A1 rs1800012 （G > T）多态性与骨质疏松或骨折风险之间的关系。共纳入30项病例对照研究，包括2943名患者和4724名对照受试者。采用Stata 11.0统计软件包进行比值比（OR）和95%置信区间的评估。结果：总体而言，隐性和纯合子模型不存在异质性，具有显著的固定效应合并OR （P < 0.001）。此外，通过随机效应分析，等位基因（P < 0.001）、显性（P < 0.001）和杂合子（P = 0.002）模型与骨质疏松症或骨折的风险显著增加相关。亚组分析显示，所有的遗传模型都显示欧洲人群骨质疏松或骨折的风险增加。此外，我们发现在北美的显性（P = 0.035）和杂合子（P = 0.030）模型中存在显著关联。此外，我们观察到COL1A1与骨质疏松症和骨折风险之间的关联。结论：结合以往研究数据，本荟萃分析提示COL1A1与骨质疏松或骨折风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Burns and Trauma EMERGENCY MEDICINE-

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