{"title":"Impact of underlying diseases and complications on COVID-19 mortality in South Korea: analysis of national health insurance service data.","authors":"Kyunghee Lee, Jieun Hwang","doi":"10.1186/s13690-025-01509-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Comorbidities or complications significantly influence coronavirus disease-2019 (COVID-19) severity and mortality risk. Therefore, this study aimed to compare treatment outcomes of COVID-19 inpatients by underlying diseases or complications.</p><p><strong>Method: </strong>Data on COVID-19 patients from the National Health Insurance Service customized research database were analyzed while focusing on eight underlying diseases and complications: diabetes, hypertension, heart disease, kidney disease, liver disease, dementia, depression, and respiratory disease.</p><p><strong>Results: </strong>Of the 377,812 COVID-19 patients in 2021, 51.47% were male and 48.53% were female, and post-diagnosis mortality was 2.04%; 68.7% (n = 259,560) of patients had at least one underlying condition, with the following frequency: respiratory disease (78.88%), heart disease (33.84%), hypertension (30.29%), liver disease (21.38%), depression (9.32%), kidney disease (4.89%), and dementia (3.87%). Among patients without any underlying diseases, 19.8% (n = 74,925) were treated for post-diagnosis complications, with the following frequency: respiratory disease (89.21%), liver disease (19.12%), heart disease (14.90%), diabetes (10.37%), hypertension (8.22%), depression (3.86%), kidney disease (2.04%), and dementia (0.64%). Except for liver disease, all underlying diseases were associated with mortality. COVID-19 patients with diabetes exhibited a 1.42-fold higher mortality risk (95% confidence interval [CI ]1.35-1.50). All complications were associated with death, with kidney-related complications conferring a 4.84-fold higher mortality risk (95% CI 3.62-6.48).</p><p><strong>Conclusion: </strong>Underlying diseases and complications in COVID-19 patients were associated with death. Even with the same disease, the timing of onset, before or after COVID-19 diagnosis, induced a difference in the mortality risk. Both underlying diseases and complications should be considered for more proactive medical interventions.</p>","PeriodicalId":48578,"journal":{"name":"Archives of Public Health","volume":"83 1","pages":"20"},"PeriodicalIF":3.4000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755852/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13690-025-01509-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Comorbidities or complications significantly influence coronavirus disease-2019 (COVID-19) severity and mortality risk. Therefore, this study aimed to compare treatment outcomes of COVID-19 inpatients by underlying diseases or complications.
Method: Data on COVID-19 patients from the National Health Insurance Service customized research database were analyzed while focusing on eight underlying diseases and complications: diabetes, hypertension, heart disease, kidney disease, liver disease, dementia, depression, and respiratory disease.
Results: Of the 377,812 COVID-19 patients in 2021, 51.47% were male and 48.53% were female, and post-diagnosis mortality was 2.04%; 68.7% (n = 259,560) of patients had at least one underlying condition, with the following frequency: respiratory disease (78.88%), heart disease (33.84%), hypertension (30.29%), liver disease (21.38%), depression (9.32%), kidney disease (4.89%), and dementia (3.87%). Among patients without any underlying diseases, 19.8% (n = 74,925) were treated for post-diagnosis complications, with the following frequency: respiratory disease (89.21%), liver disease (19.12%), heart disease (14.90%), diabetes (10.37%), hypertension (8.22%), depression (3.86%), kidney disease (2.04%), and dementia (0.64%). Except for liver disease, all underlying diseases were associated with mortality. COVID-19 patients with diabetes exhibited a 1.42-fold higher mortality risk (95% confidence interval [CI ]1.35-1.50). All complications were associated with death, with kidney-related complications conferring a 4.84-fold higher mortality risk (95% CI 3.62-6.48).
Conclusion: Underlying diseases and complications in COVID-19 patients were associated with death. Even with the same disease, the timing of onset, before or after COVID-19 diagnosis, induced a difference in the mortality risk. Both underlying diseases and complications should be considered for more proactive medical interventions.
期刊介绍：
rchives of Public Health is a broad scope public health journal, dedicated to publishing all sound science in the field of public health. The journal aims to better the understanding of the health of populations. The journal contributes to public health knowledge, enhances the interaction between research, policy and practice and stimulates public health monitoring and indicator development. The journal considers submissions on health outcomes and their determinants, with clear statements about the public health and policy implications. Archives of Public Health welcomes methodological papers (e.g., on study design and bias), papers on health services research, health economics, community interventions, and epidemiological studies dealing with international comparisons, the determinants of inequality in health, and the environmental, behavioural, social, demographic and occupational correlates of health and diseases.
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