Epidemiological characteristics and risk factors for heart failure in Japanese patients with type 2 diabetes: A retrospective analysis of the J-DREAMS database

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Investigation Pub Date : 2025-01-24 DOI:10.1111/jdi.14378

Mitsuru Ohsugi, Daisuke Nitta, Yusuke Naito, Kohjiro Ueki

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Abstract

Aim

To determine the epidemiological characteristics and risk factors for heart failure (HF) among Japanese patients with type 2 diabetes.

Methods

A retrospective cohort analysis, using J-DREAMS database, was conducted from December 2015 to January 2020 with type 2 diabetes. The primary objectives were to describe patient characteristics stratified by HF history at baseline and new HF events during follow-up. The secondary objectives were to clarify the association between HF history or new HF events and clinical characteristics. The association between renal disease stage and HF was also studied.

Results

Among 18,250 adult patients with type 2 diabetes, 3,613 (19.8%) patients had HF history and the mean age was 68.46 years, predominantly male (66.4%) with 13.32 years of mean duration of type 2 diabetes. Patients with HF history had a higher proportion of patients with nephropathy (51.2%) and coronary heart disease (55.6%) than those without HF history. Coronary heart disease (CHD) and deteriorating renal function were strongly associated with both HF history (CHD adjusted odds ratio [OR]: 7.41, 95% confidence interval [CI]: 6.05–9.08; eGFR G5 stage adjusted OR: 6.56, 95% CI: 2.97–14.49) and new HF events (CHD adjusted OR: 1.63, 95% CI: 1.17–2.29; eGFR G4 stage adjusted OR: 3.42, 95% CI: 1.81–6.47).

Conclusions

Comorbidities, especially CHD and deteriorating renal function, were strongly associated with HF history and new HF events among Japanese patients with type 2 diabetes. The study results suggested the importance of early intervention to treat comorbidities and maintain renal function.

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日本2型糖尿病患者心力衰竭的流行病学特征和危险因素：J-DREAMS数据库的回顾性分析

目的：了解日本2型糖尿病患者心力衰竭（HF）的流行病学特征及危险因素。方法：采用J-DREAMS数据库，对2015年12月至2020年1月2型糖尿病患者进行回顾性队列分析。主要目的是根据基线时的心衰病史和随访期间的新心衰事件来描述患者的特征。次要目的是澄清心衰病史或新发心衰事件与临床特征之间的关系。还研究了肾脏疾病分期与心衰之间的关系。结果：18250例成年2型糖尿病患者中，3613例（19.8%）有HF病史，平均年龄68.46岁，以男性为主（66.4%），平均2型糖尿病病程13.32年。有心衰病史的患者合并肾病（51.2%）和冠心病（55.6%）的比例高于无心衰病史的患者。冠心病（CHD）和肾功能恶化与心衰史密切相关(CHD校正优势比[OR]: 7.41, 95%可信区间[CI]: 6.05-9.08；eGFR G5阶段调整OR: 6.56, 95% CI: 2.97-14.49)和新的HF事件(冠心病调整OR: 1.63, 95% CI: 1.17-2.29；eGFR G4分期调整OR: 3.42, 95% CI: 1.81-6.47)。结论：在日本2型糖尿病患者中，合并症，尤其是冠心病和肾功能恶化，与HF病史和新发HF事件密切相关。研究结果提示早期干预对治疗合并症和维持肾功能的重要性。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).