The Constrained Disorder Principle Overcomes the Challenges of Methods for Assessing Uncertainty in Biological Systems.

Abstract

Different disciplines are developing various methods for determining and dealing with uncertainties in complex systems. The constrained disorder principle (CDP) accounts for the randomness, variability, and uncertainty that characterize biological systems and are essential for their proper function. Per the CDP, intrinsic unpredictability is mandatory for the dynamicity of biological systems under continuously changing internal and external perturbations. The present paper describes some of the parameters and challenges associated with uncertainty and randomness in biological systems and presents methods for quantifying them. Modeling biological systems necessitates accounting for the randomness, variability, and underlying uncertainty of systems in health and disease. The CDP provides a scheme for dealing with uncertainty in biological systems and sets the basis for using them. This paper presents the CDP-based second-generation artificial intelligence system that incorporates variability to improve the effectiveness of medical interventions. It describes the use of the digital pill that comprises algorithm-based personalized treatment regimens regulated by closed-loop systems based on personalized signatures of variability. The CDP provides a method for using uncertainties in complex systems in an outcome-based manner.