Exposure to Volatile Organic Compounds in Relation to Visceral Adiposity Index and Lipid Accumulation Product Among U.S. Adults: NHANES 2011-2018.

Abstract

Volatile organic compounds (VOCs) are associated with obesity health risks, while the association of mixed VOCs with visceral adiposity indicators remains unclear. In this study, a total of 2015 adults from the National Health and Nutrition Examination Survey (NHANES) were included. Weighted generalized linear models, restricted cubic spline (RCS), weighted quantile sum (WQS), and Bayesian kernel machine regression (BKMR) were adopted to assess the association of VOC metabolites (mVOCs) with the visceral adiposity index (VAI) and lipid accumulation product (LAP). Multiple mVOCs were positively associated with the VAI and LAP in the single-exposure model, especially N-acetyl-S-(2-carboxyethyl)-L-cysteine (CEMA) and N-acetyl-S-(N-methylcarbamoyl)-L-cysteine (AMCC). The associations of mVOCs with VAI and LAP were more significant in <60-year-old and non-obese individuals, with interactions of CEMA with age and AMCC with obesity status. Nonlinear relationships between certain mVOCs and the VAI or the LAP were also observed. In the WQS model, co-exposure to mVOCs was positively correlated with the VAI [β (95%CI): 0.084 (0.022, 0.147)]; CEMA (25.24%) was the major contributor. The result of the BKMR revealed a positive trend of the association between mixed mVOCs and the VAI. Our findings suggest that VOC exposure is strongly associated with visceral obesity indicators. Further large prospective investigations are necessary to support our findings.