Count-rate management in 131I SPECT/CT calibration.

Abstract

Background: System calibration is essential for accurate SPECT/CT dosimetry. However, count losses due to dead time and pulse pileup may cause calibration errors, in particular for ¹³¹I, where high count rates may be encountered. Calibration at low count rates should also be avoided to minimise detrimental effects from e.g. background counts and statistical fluctuations. This paper aims to present experimental data illustrating count-rate dependencies and to propose practical routines to mitigate errors in the ¹³¹I calibration procedure without needing advanced analysis tools.

Results: The sensitivities of two General Electric (GE) Discovery 670 Pro systems were assessed using two Jaszczak phantom geometries. SPECT/CT data were collected over two months, starting with an initial ¹³¹I content of > 2 GBq, decaying to approximately 20 MBq. This allowed for a detailed analysis of count losses due to dead time and pulse pileup. From the sensitivity analysis, it was shown that robust calibration was obtained for ¹³¹I phantom activities ranging between 250 and 1500 MBq.

Conclusions: The results show that adequate corrections for dead-time and pulse-pileup counting losses are essential for accurate calibration. It is argued that loss corrections should be based on total spectrum count rates in projections and not only on the 364.5 keV energy window data. The measurement campaigns presented in this paper, using basic tools and equipment, may serve as a model for establishing routines for count-loss corrections as well as for system calibration and regular control of system sensitivity. The data suggest that analysis of source and count concentration in a homogeneous Jaszczak phantom offers robust calibration, whereas analysis of source strength and counts in a delineated phantom insert offers a practical and robust method for regular quality control.