LONG-LASTING EFFECTS OF EARLY POSTNATAL DYSFUNCTION OF THE BRAIN MUSCARINIC CHOLINERGIC SYSTEM ON LEARNING AND MEMORY AND ADULT HIPPOCAMPAL NEUROGENESIS.

Q4 Medicine Georgian medical news Pub Date : 2024-11-01

M Shavgulidze, N Maglakelidze, N Rogava, Kh Bezhanishvili, N Nachkebia

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Abstract

Aim: The present investigation aimed to explore in rats the early postnatal dysfunction of the brain muscarinic cholinergic system (EPDMChS) during the most vulnerable period of postnatal development, as the possible main factor for changes in adult hippocampal neurogenesis and disorders in hippocampus-dependent spatial learning and memory.

Methods: White inbred rats (n=15 in each group) were used. EPDMCHS was produced by a new method, which includes early postnatal blocking of M1-M5 muscarinic acetylcholine receptors in the rat pups, using subcutaneous injection of Scopolamine during postnatal days 7-28. Control rat pups received the same volume as Saline. Researches were started in adult age (2.5-3 months).

Results and conclusion: It was shown for the first time that EPDMCHS exerts long-lasting effects manifested in adult age in the impairment of hippocampal neurogenesis and significant deterioration of spatial long-term declarative memory in the MWM. The possible causal link between the EPDMCHS and two types of resulting disorders is underlined.

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出生后早期大脑毒蕈碱胆碱能系统功能障碍对学习记忆和成年海马神经发生的持久影响。

目的：本研究旨在探讨大鼠出生后最脆弱时期脑毒蕈碱胆碱能系统（EPDMChS）的早期功能障碍，作为成年海马神经发生改变和海马依赖性空间学习记忆障碍的可能主要因素。方法：选用白色近交系大鼠，每组15只。EPDMCHS是通过一种新方法产生的，该方法包括在出生后7-28天早期通过皮下注射东莨菪碱阻断大鼠幼鼠M1-M5毒蕈碱乙酰胆碱受体。对照大鼠幼崽接受等量的生理盐水。研究开始于成年期（2.5-3个月）。结果与结论：首次发现EPDMCHS具有长效作用，表现在成年期大鼠海马神经发生损伤和空间长时陈述性记忆显著下降。强调了EPDMCHS与两种导致的疾病之间可能的因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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