Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population.

IF 2.1 4区医学 Q2 PEDIATRICS Children-Basel Pub Date : 2025-01-17 DOI:10.3390/children12010104

Hery Priyanto, Fauqa Arinil Aulia, Hartono Kahar, Muhammad Faizi, Ferdy Royland Marpaung, Aryati Aryati

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Abstract

(1) Background: This study is designed to establish thyroid-stimulating hormone (TSH) reference intervals tailored to different neonatal age groups and Indonesian local populations. (2) Methods: Dried blood spot neonatal TSH values, from 1 January 2022 to 31 December 2023, were used to establish the neonatal TSH reference intervals partitioned by sex, gestational age, and ethnic group at different neonatal ages. (3) Results: A significant difference in the reference intervals value was observed in sex, gestational ages, and parental ethnicity groups in different neonatal age subgroups (p < 0.05). Male reference intervals were significantly higher than those of females at all neonatal ages. Late and post-term gestational age categories reference intervals were higher than early and full-term. Among the ethnic groups, Madurese had a higher upper limit TSH reference interval. (4) Conclusions: Our neonatal TSH reference intervals were needed to provide a reference adapted to the local population of Indonesia.

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多民族新生儿促甲状腺激素参考区间。

(1)背景：本研究旨在建立适合不同新生儿年龄组和印度尼西亚当地人群的促甲状腺激素（TSH）参考区间。(2)方法：利用2022年1月1日至2023年12月31日的新生儿干血斑TSH值，建立按性别、胎龄、民族划分的新生儿TSH参考区间。(3)结果：不同新生儿年龄亚组的参考区间值在性别、胎龄、父母种族间存在显著差异（p < 0.05）。在所有新生儿年龄，男性参考区间均显著高于女性。晚期和晚期胎龄分类参考区间高于早期和足月。各民族中，马杜洛雷人TSH参考区间上限较高。(4)结论：我们的新生儿TSH参考区间需要提供一个适合印度尼西亚当地人群的参考。

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来源期刊

Children-Basel PEDIATRICS-

CiteScore

2.70

自引率

16.70%

发文量

1735

审稿时长

6 weeks

期刊介绍： Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.