{"title":"Egg reappearance periods associated with anthelmintic treatments given to horses in winter and summer over two years","authors":"Ian Scott, Kevin E. Lawrence, Erica K. Gee","doi":"10.1016/j.vprsr.2024.101182","DOIUrl":null,"url":null,"abstract":"<div><div>Shortened egg reappearance periods (ERP) have been seen as an early warning of anthelmintic resistance development in cyathostomins in horses. The hypothesis has been that in these instances, efficacy against egg laying adult cyathostomins remains high, but a decline in activity against later larval stages leads to the earlier resumption of egg shedding after treatment. In this study using a single herd of horses we investigated the ERP of a number of commonly used equine anthelmintics and examined whether ERP might show seasonal variation between winter and summer. Four main Faecal egg count reduction tests (FECRT1–4) were conducted respectively in Winter (Jun/Jul) 2019, Summer (Jan/Feb) 2020, Winter 2020 and Summer 2021. The tests examined the efficacy and ERP of ivermectin, moxidectin, abamectin and fenbendazole. Egg counts of two groups of horses were monitored before and for 6–7 weeks after treatment - however long it took for counts to return to at least 10 % of what they had been before treatment. One additional FECRT was also conducted, using a second abamectin-containing product (FECRT5 - Spring 2020). Treatment with ivermectin (FECRT1–4), moxidectin (FECRT 1–2) and the first abamectin product tested (FECRT3) all reduced egg counts by >99 % for 4 weeks after treatment, with ERP of 5–7 weeks and with minimal differences between the 3 treatments. There was a tendency for counts to rise more rapidly in summer, and in the second year of testing as opposed to the first. Both the second abamectin product (FECRT5) and the fenbendazole (FECRT4) were found to be ineffective, reducing egg counts immediately after treatment by 68 and 52 % respectively.</div></div>","PeriodicalId":23600,"journal":{"name":"Veterinary parasitology, regional studies and reports","volume":"57 ","pages":"Article 101182"},"PeriodicalIF":1.4000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary parasitology, regional studies and reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405939024002181","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Shortened egg reappearance periods (ERP) have been seen as an early warning of anthelmintic resistance development in cyathostomins in horses. The hypothesis has been that in these instances, efficacy against egg laying adult cyathostomins remains high, but a decline in activity against later larval stages leads to the earlier resumption of egg shedding after treatment. In this study using a single herd of horses we investigated the ERP of a number of commonly used equine anthelmintics and examined whether ERP might show seasonal variation between winter and summer. Four main Faecal egg count reduction tests (FECRT1–4) were conducted respectively in Winter (Jun/Jul) 2019, Summer (Jan/Feb) 2020, Winter 2020 and Summer 2021. The tests examined the efficacy and ERP of ivermectin, moxidectin, abamectin and fenbendazole. Egg counts of two groups of horses were monitored before and for 6–7 weeks after treatment - however long it took for counts to return to at least 10 % of what they had been before treatment. One additional FECRT was also conducted, using a second abamectin-containing product (FECRT5 - Spring 2020). Treatment with ivermectin (FECRT1–4), moxidectin (FECRT 1–2) and the first abamectin product tested (FECRT3) all reduced egg counts by >99 % for 4 weeks after treatment, with ERP of 5–7 weeks and with minimal differences between the 3 treatments. There was a tendency for counts to rise more rapidly in summer, and in the second year of testing as opposed to the first. Both the second abamectin product (FECRT5) and the fenbendazole (FECRT4) were found to be ineffective, reducing egg counts immediately after treatment by 68 and 52 % respectively.
期刊介绍：
Veterinary Parasitology: Regional Studies and Reports focuses on aspects of veterinary parasitology that are of regional concern, which is especially important in this era of climate change and the rapid and often unconstrained travel of people and animals. Relative to regions, this journal will accept papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites within the field of veterinary medicine. Also, case reports will be considered as they add to information related to local disease and its control; such papers must be concise and represent appropriate medical intervention. Papers on veterinary parasitology from wildlife species are acceptable, but only if they relate to the practice of veterinary medicine. Studies on vector-borne bacterial and viral agents are suitable, but only if the paper deals with vector transmission of these organisms to domesticated animals. Studies dealing with parasite control by means of natural products, both in vivo and in vitro, are more suited for one of the many journals that now specialize in papers of this type. However, due to the regional nature of much of this research, submissions may be considered based upon a case being made by the author(s) to the Editor. Circumstances relating to animal experimentation must meet the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for International Organizations of Medical Sciences (obtainable from: Executive Secretary C.I.O.M.S., c/o W.H.O., Via Appia, CH-1211 Geneva 27, Switzerland).
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